From Wikipedia, the free encyclopedia
Clinical data
Other namesISIS-426115; ISIS-GCCRRx
Drug classAntiglucocorticoid

IONIS-GCCRRx, also known as ISIS-426115, is an antiglucocorticoid which is under development by Ionis Pharmaceuticals (formerly Isis Pharmaceuticals) for the treatment of diabetes mellitus type 2.[1][2] It has also been under investigation for the treatment of Cushing's syndrome, but no development has been reported.[1] The drug is an antisense oligonucleotide against the glucocorticoid receptor.[1] As of December 2017, it is in phase II clinical trials for diabetes mellitus type 2.[1]


  1. ^ a b c d "IONIS GCCRRx". AdisInsight. Springer Nature Switzerland AG.
  2. ^ Chikara G, Sharma PK, Dwivedi P, Charan J, Ambwani S, Singh S (April 2018). "A Narrative Review of Potential Future Antidiabetic Drugs: Should We Expect More?". Indian Journal of Clinical Biochemistry. 33 (2): 121–131. doi:10.1007/s12291-017-0668-z. PMC 5891460. PMID 29651202.