|Trade names||Antofin, Previsone, Pregno-Pan|
|Synonyms||Pregn-5-en-3β-ol-20-one 3β-acetate, Antofin, Artivis, Enescorb, Previsone, Sharmone, Pregnenolone-3-acetate, 1778-02-5, 3α-Acetoxy-5-pregnen-20-one, ZINC6304690, NSC 64827, Acetic acid 20-oxopregn-5-en-3alpha-yl ester|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||358.522 g·mol−1|
|3D model (JSmol)|
Pregnenolone acetate (brand names Antofin, Previsone, Pregno-Pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent. It has been found to significantly reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin. Pregnenolone acetate has been marketed in France in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992. Although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high dosages.
- National Center for Biotechnology Information. PubChem Compound Database; CID=11013784, https://pubchem.ncbi.nlm.nih.gov/compound/11013784 (accessed Mar. 10, 2019).
- J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 665–. ISBN 978-1-4757-2085-3.
- Council of Europe. Committee of Experts on Cosmetic Products (2008). Active Ingredients Used in Cosmetics: Safety Survey. Council of Europe. pp. 325–. ISBN 978-92-871-6298-4.
- Lamb JH, Kelly FC, Shackelford PO, Rebell G, Koons RC (1953). "Pregnenolone acetate in treatment of mycetoma (nocardiosis)". AMA Arch Derm Syphilol. 67 (2): 141–5. PMID 13029897.
|This article about a steroid is a stub. You can help Wikipedia by expanding it.|