Difluprednate

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Difluprednate
Difluprednate.svg
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa609025
License data
Routes of
administration
topical dermatologic
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.636 Edit this at Wikidata
Chemical and physical data
FormulaC27H34F2O7
Molar mass508.551 g·mol−1
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Difluprednate is a corticosteroid, It is chemically a butyrate ester of 6(alpha),9(alpha)-difluoro prednisolone acetate. Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate.

Approval[edit]

On June 24, 2008, the US Food and Drug Administration (FDA) approved difluprednate for the treatment of post-operative ocular inflammation and pain.[1] It is marketed by Alcon under the tradename Durezol.

Clinical trials[edit]

Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a U.S. Phase 3 study evaluating difluprednate for the treatment of anterior uveitis.[2][3]

References[edit]

  1. ^ "Sirion Therapeutics Announces FDA Approval of Durezol for Treatment of Postoperative Ocular Inflammation and Pain" (Press release). Sirion Therapeutics, Inc. 2008-06-24. Retrieved 2008-06-30.
  2. ^ ClinicalTrials.gov
  3. ^ {Sheppard J, Toyos M, Kempen, J, Kaur P, Foster C "Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized study. Invest Opthalmol Vis Sci 2014 May 6;55(5):2993-3002. doi:10.1167/iovs.13-12660.