OR1G1
| OR1G1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR1G1, OR17-130, OR17-209, OR1G2, olfactory receptor family 1 subfamily G member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | HomoloGene: 105311; GeneCards: OR1G1; OMA:OR1G1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 1G1 is a protein that in humans is encoded by the OR1G1 gene.[3][4][5]
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
The OR1G1 receptor is associated with sensory sensations including "waxy", "fatty", and "rose",[6] and also "fruity" and "sweet".[7]
Compared to other olfactory receptors such as OR52D1, OR1G1 is broadly tuned to respond to odorants in different chemical classes, but it is sensitive to chain length, responding most strongly to chains of 9-10 carbons.[8]
Examples of agonists include:
- nonanal (strong)[8]
- 1-nonanol (strong)[8]
- 2-ethyl-1-hexanol (strong)[8]
- γ-decalactone (strong)[8]
- ethyl isobutyrate (strong)[8]
- 1-octanol[7]
- celery ketone[7]
- citral[8][7]
- isoamyl acetate[9]
Example antagonists include:
The pattern of 6-carbon antagonists compared to ~9-carbon agonists is likely explained by OR1G1 having a deep pocket at its binding site, such that the 6-carbon molecules block the opening, but do not reach the bottom of the deep pocket as required to activate the signal transduction chain.[8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183024 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, et al. (February 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Human Molecular Genetics. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
- ^ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (March 1998). "Distribution of olfactory receptor genes in the human genome". Nature Genetics. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
- ^ a b "Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1".
- ^ Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, et al. (September 2008). "Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor". Chemical Senses. 33 (7): 639–53. doi:10.1093/chemse/bjn032. PMID 18603653.
- ^ a b c d Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.
- ^ a b c d e f g h i j k Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.
- ^ Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, et al. (March 2005). "Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system". Chemical Senses. 30 (3): 195–207. doi:10.1093/chemse/bji015. PMID 15741602.
Further reading
- Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
- Matarazzo V, Zsürger N, Guillemot JC, Clot-Faybesse O, Botto JM, Dal Farra C, et al. (October 2002). "Porcine odorant-binding protein selectively binds to a human olfactory receptor". Chemical Senses. 27 (8): 691–701. doi:10.1093/chemse/27.8.691. PMID 12379593.
- Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
- OR1G1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.