OR2M3

OR2M3
Identifiers
Aliases	OR2M3, OR1-54, OR2M3P, OR2M6, OST003, olfactory receptor family 2 subfamily M member 3
External IDs	MGI: 3029998; HomoloGene: 51725; GeneCards: OR2M3; OMA:OR2M3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q44 Start 248,197,265 bp End 248,212,925 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 A3 Start 19,102,854 bp End 19,132,814 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon sural nerve rectum endometrium renal cortex prefrontal cortex muscle layer of sigmoid colon fundus Top expressed in spleen uterus thymus duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127062 258443 Ensembl ENSG00000228198 ENSMUSG00000050742 UniProt Q8NG83 Q8VF87 RefSeq (mRNA) NM_001004689 NM_146451 RefSeq (protein) NP_001004689 NP_666662 Location (UCSC) Chr 1: 248.2 – 248.21 Mb Chr 16: 19.1 – 19.13 Mb PubMed search
Wikidata
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Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

OR2M3 has a copper binding pocket.

Ligands

• 3-Mercapto-2-methylpentan-1-ol

This chemical is associated with characteristic smell of raw onions.

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR2M3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.