OR4F4

OR4F4
Identifiers
Aliases	OR4F4, OLA-7501, OR4F18, olfactory receptor family 4 subfamily F member 4
External IDs	MGI: 3031123; HomoloGene: 128250; GeneCards: OR4F4; OMA:OR4F4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.3 Start 101,922,042 bp End 101,923,113 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E3 Start 111,311,164 bp End 111,314,960 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve fundus blood muscle of leg heart esophagus adrenal gland Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26682 258399 Ensembl ENSG00000177693 ENSMUSG00000061195 UniProt Q96R69 Q8VF49 RefSeq (mRNA) NM_001004195 NM_146404 RefSeq (protein) NP_001004195 NP_666516 Location (UCSC) Chr 15: 101.92 – 101.92 Mb Chr 2: 111.31 – 111.31 Mb PubMed search
Wikidata
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Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes". Hum. Mol. Genet. 7 (1): 13–26. doi:10.1093/hmg/7.1.13. PMID 9384599.
• Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID 11689483.
• Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location". Hum. Mol. Genet. 10 (21): 2373–83. doi:10.1093/hmg/10.21.2373. PMID 11689484.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR4F4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.