OR8I2

OR8I2
Identifiers
Aliases	OR8I2, OR11-170, olfactory receptor family 8 subfamily I member 2
External IDs	MGI: 3030938; HomoloGene: 64916; GeneCards: OR8I2; OMA:OR8I2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.1 Start 56,093,308 bp End 56,094,240 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 D Start 86,851,047 bp End 86,857,424 bp
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity odorant binding Cellular component integral component of membrane plasma membrane membrane Biological process response to stimulus signal transduction sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120586 258763 Ensembl ENSG00000172154 ENSMUSG00000075166 UniProt Q8N0Y5 A2AVB5 RefSeq (mRNA) NM_001003750 NM_146767 RefSeq (protein) NP_001003750 NP_666978 Location (UCSC) Chr 11: 56.09 – 56.09 Mb Chr 2: 86.85 – 86.86 Mb PubMed search
Wikidata
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Olfactory receptor 8I2 is a protein that in humans is encoded by the OR8I2 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR8I2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.