Carboxylesterase 3

CES3
Identifiers
Aliases	CES3, ES31, carboxylesterase 3
External IDs	OMIM: 605279; MGI: 102773; HomoloGene: 84407; GeneCards: CES3; OMA:CES3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,975,149 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,785,045 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; right lobe of liver; ; mucosa of sigmoid colon; ; mucosa of ileum; ; muscle of thigh; ; gastrocnemius muscle; ; jejunal mucosa; ; duodenum; ; tendon of biceps brachii;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; proximal tubule; ; pancreas; ; colon; ; ileum; ; jejunum; ; spermatid; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; carboxylic ester hydrolase activity; sterol esterase activity; triglyceride lipase activity; methyl indole-3-acetate esterase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular exosome; cytosol; extracellular space;
Biological process	xenobiotic metabolic process; low-density lipoprotein particle clearance; lipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23491
	382053
	ENSG00000172828
	ENSMUSG00000069922
	Q6UWW8
	Q63880
	NM_001185176; NM_001185177; NM_012122; NM_024922
	NM_001164681; NM_198672
	NP_001172105; NP_001172106; NP_079198
	NP_001158153; NP_941074
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene.^[5]^[6]^[7]^[8]

Function

Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172828 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069922 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (Oct 1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett. 458 (1): 17–22. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925.
^ Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF (Oct 2003). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res. 9 (13): 4983–91. PMID 14581373.
^ Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF (Apr 2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505–11. doi:10.1124/dmd.32.5.505. PMID 15100172.
^ ^a ^b "Entrez Gene: CES3 carboxylesterase 3 (brain)".

Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells". Blood. 108 (9): 3103–11. doi:10.1182/blood-2006-03-011031. PMID 16840730.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver" (PDF). Biochim. Biophys. Acta. 1174 (1): 72–4. doi:10.1016/0167-4781(93)90093-s. PMID 7916639.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172828 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069922 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10518925-5] Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (Oct 1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett. 458 (1): 17–22. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925.

[pmid14581373-6] Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF (Oct 2003). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res. 9 (13): 4983–91. PMID 14581373.

[pmid15100172-7] Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF (Apr 2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505–11. doi:10.1124/dmd.32.5.505. PMID 15100172.

[entrez-8] "Entrez Gene: CES3 carboxylesterase 3 (brain)".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

References

Further reading