Carboxylesterase 3

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CES3
Identifiers
AliasesCES3, ES31, carboxylesterase 3
External IDsOMIM: 605279 MGI: 102773 HomoloGene: 84407 GeneCards: CES3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CES3
Genomic location for CES3
Band16q22.1Start66,961,245 bp[1]
End66,975,149 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001185176
NM_001185177
NM_012122
NM_024922

NM_001164681
NM_198672

RefSeq (protein)

NP_001172105
NP_001172106
NP_079198

NP_001158153
NP_941074

Location (UCSC)Chr 16: 66.96 – 66.98 MbChr 8: 105.05 – 105.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene.[5][6][7][8]

Function[edit]

Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172828 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069922 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (Oct 1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett. 458 (1): 17–22. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925.
  6. ^ Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF (Oct 2003). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res. 9 (13): 4983–91. PMID 14581373.
  7. ^ Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF (Apr 2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505–11. doi:10.1124/dmd.32.5.505. PMID 15100172.
  8. ^ a b "Entrez Gene: CES3 carboxylesterase 3 (brain)".

Further reading[edit]