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CYP2F1

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CYP2F1
Identifiers
AliasesCYP2F1, C2F1, CYP2F, CYPIIF1, cytochrome P450 family 2 subfamily F member 1
External IDsOMIM: 124070; MGI: 88608; HomoloGene: 73898; GeneCards: CYP2F1; OMA:CYP2F1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000774

NM_007817

RefSeq (protein)

NP_000765

NP_031843

Location (UCSC)Chr 19: 41.11 – 41.13 MbChr 7: 26.82 – 26.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates, such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197446Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052974Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1".

Further reading