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Georg Nagel

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Georg Nagel (born on 24. August 1953 in Weingarten, Germany) is a Biophysicist and Professor at the Department for Neurophysiology at the University of Würzburg in Germany. His research is focused on microbial photoreceptors and the development of optogenetic tools.

Scientific career

Georg Nagel studied Biology and Biophysics at the University of Konstanz, Germany. He received his PhD from the University of Frankfurt in 1988, working at the Max Planck Institute of Biophysics in Frankfurt. As a postdoc, he worked at Yale University and Rockefeller University, USA. From 1992 to 2004, he headed an independent research group in the Department of Biophysical Chemistry at the Max Planck Institute of Biophysics in Frankfurt. Since 2004, he is Professor at the University of Würzburg, Germany, first at the Department for Molecular Plant Physiology and Biophysics, since 2019 at the Department for Neurophysiology.

Research

Georg Nagel, together with Peter Hegemann, is credited with the discovery of channelrhodopsins, which opened the new field of optogenetics.[1]

Early in 1995, Georg Nagel and Ernst Bamberg demonstrated that a microbial rhodopsin (Bacteriorhodopsin), when expressed in animal cells (Xenopus oocytes), is fully functional.[2]

In 2003, Nagel showed the functionality of Channelrhodopsin-2 (ChR2) in a mammalian cell line, where illumination with blue light caused a strong depolarization of the membrane potential.[3]

Following this proof-of-principle publication, ChR2 was expressed in hippocampal neurons in collaboration with Karl Deisseroth, where light pulses caused action potentials with high temporal precision.[4]

The first application of optogenetics in an intact animal, the round worm Caenorhabditis elegans, published 2005 by Georg Nagel and Alexander Gottschalk, was based on a ChR2 mutant (H134R) Nagel had created to improve photocurrents.[5]

The first successful optogenetic inhibition of neuronal spiking (2007) was based on Georg Nagel's earlier experiments with Halorhodopsin from Natronomonas pharaonis.[6]

In 2007, in another collaboration with Peter Hegemann, Georg Nagel started the optogenetic manipulation of cAMP.[7]

In 2015, Georg Nagel and his group members Gao et al, together with Alexander Gottschalk group, characterized the first 8 TM enzyme rhodopsin, Cyclop.[8]

Awards (selection)

References

  1. ^ Nagel, G. (2002-06-28). "Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae". Science. 296 (5577): 2395–2398. doi:10.1126/science.1072068. PMID 12089443. S2CID 206506942.
  2. ^ Nagel, Georg; Möckel, Bettina; Büldt, Georg; Bamberg, Ernst (1995-12-18). "Functional expression of bacteriorhodopsin in oocytes allows direct measurement of voltage dependence of light induced H + pumping". FEBS Letters. 377 (2): 263–266. doi:10.1016/0014-5793(95)01356-3. PMID 8543064. S2CID 24347348.
  3. ^ Nagel, G.; Szellas, T.; Huhn, W.; Kateriya, S.; Adeishvili, N.; Berthold, P.; Ollig, D.; Hegemann, P.; Bamberg, E. (2003-11-25). "Channelrhodopsin-2, a directly light-gated cation-selective membrane channel". Proceedings of the National Academy of Sciences. 100 (24): 13940–13945. doi:10.1073/pnas.1936192100. ISSN 0027-8424. PMC 283525. PMID 14615590.
  4. ^ Boyden, Edward S; Zhang, Feng; Bamberg, Ernst; Nagel, Georg; Deisseroth, Karl (2005). "Millisecond-timescale, genetically targeted optical control of neural activity". Nature Neuroscience. 8 (9): 1263–1268. doi:10.1038/nn1525. ISSN 1097-6256. PMID 16116447. S2CID 6809511.
  5. ^ Nagel, Georg; Brauner, Martin; Liewald, Jana F.; Adeishvili, Nona; Bamberg, Ernst; Gottschalk, Alexander (2005). "Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses". Current Biology. 15 (24): 2279–2284. doi:10.1016/j.cub.2005.11.032. PMID 16360690. S2CID 7036529.
  6. ^ Zhang, Feng; Wang, Li-Ping; Brauner, Martin; Liewald, Jana F.; Kay, Kenneth; Watzke, Natalie; Wood, Phillip G.; Bamberg, Ernst; Nagel, Georg; Gottschalk, Alexander; Deisseroth, Karl (2007). "Multimodal fast optical interrogation of neural circuitry". Nature. 446 (7136): 633–639. doi:10.1038/nature05744. ISSN 1476-4687. PMID 17410168. S2CID 4415339.
  7. ^ Schröder-Lang, Saskia; Schwärzel, Martin; Seifert, Reinhard; Strünker, Timo; Kateriya, Suneel; Looser, Jens; Watanabe, Masakatsu; Kaupp, U Benjamin; Hegemann, Peter; Nagel, Georg (2007). "Fast manipulation of cellular cAMP level by light in vivo". Nature Methods. 4 (1): 39–42. doi:10.1038/nmeth975. ISSN 1548-7091. PMID 17128267. S2CID 10616442.
  8. ^ Gao, Shiqiang; Nagpal, Jatin; Schneider, Martin W.; Kozjak-Pavlovic, Vera; Nagel, Georg; Gottschalk, Alexander (2015). "Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp". Nature Communications. 6 (1): 8046. doi:10.1038/ncomms9046. ISSN 2041-1723. PMC 4569695. PMID 26345128.
  9. ^ Ninth Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Peter Hegemann, Dr. Georg Nagel, and Dr. Ernst Bamberg (wiley.com)
  10. ^ Preisträger Archived 2010-07-04 at the Wayback Machine of the Karl Heinz Beckurts Foundation (beckurts-stiftung.de)
  11. ^ Louis-Jeantet Prize
  12. ^ Peter Hegemann Archived 2015-12-30 at the Wayback Machine thebrainprize.org
  13. ^ "Rumford Prize Awarded for the Invention and Refinement of Optogenetics". American Academy of Arts & Sciences. Retrieved 2019-03-12.
  14. ^ Shaw Prize 2020
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