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Bonnie Lynn Bassler
1962 (age 55–56)
|Alma mater||University of California, Davis|
Johns Hopkins University
|Known for||Quorum sensing|
|Awards||Wiley Prize in Biomedical Science (2009)|
Richard Lounsbery Award (2011)
Shaw Prize (2015)
Pearl Meister Greengard Prize (2016)
Fellow of the Royal Society
Bonnie Lynn Bassler, Ph.D (born 1962) is an American molecular biologist who revolutionized microbiology with her discovery of the use of chemical communication between bacteria known as quorum sensing, as well as the idea that disruption of chemical signaling could be used as an antimicrobial therapy. She is a professor at Princeton University and Howard Hughes Medical Institute in microbiology and virology with a research focus in cell-to-cell communication in bacteria. She received the Wiley Prize in Biomedical Sciences (2009), the Richard Lounsbery Award (2011), and the L’Oreal-UNESCO award (2012), the MacArthur Fellowship (2002), the Pearl Meister Greengard Prize (2016) for her paradigm-changing scientific research and was made a member of the Royal Society and the American Philosophical Society in 2012. She sits on the National Science Board and was nominated to that position by Barack Obama.
Early life and education
Born in Chicago and raised in Danville, California, Bassler received a Bachelor of Science in biochemistry from the University of California, Davis and a Ph.D. in biochemistry from Johns Hopkins University. She made key insights into the mechanism by which bacteria communicate, known as quorum sensing. Her postdoctoral research was conducted at Agouron Institute in genetics before joining the Princeton faculty in 1994.
Honors and awards
Bassler was elected to the National Academy of Sciences in 2006. She was elected a Fellow of the American Academy of Arts and Sciences in 2007. In 2008, she received a special recognition from the World Cultural Council. She is an elected member of the American Association for the Advancement of Science since 2004, and a member in the American Philosophical Society since 2012.
Bassler has been nominated by the American Society for Microbiology to be one of the USA Science and Engineering Festival's Nifty Fifty Speakers who will speak about her work and career to middle and high school students in October 2010. The Nifty Fifty is a collection of the most influential scientists and engineers in the United States, that are dedicated to reinvigorating the interest of young people in science and engineering. She has won the Wiley prize in Biomedical Sciences in 2009 for "pioneering investigations of quorum sensing, a mechanism that allows bacteria to “talk” to each other to coordinate their behavior, even between species." In 2011, she won a Richard Lounsbery Award "For her pioneering discoveries of the universal use of chemical communication among bacteria and the elucidation of structural and regulatory mechanisms controlling bacterial assemblies."  Bonnie Bassler was named 2011 L'Oréal-UNESCO For Women in Science Awards Laureate for North America and received the Royal Society Fellowship Award the following year. She received honorary degrees from Tufts University and Bates College also in 2012. In 2014, Bassler was awarded the Excellence in Teaching Award and EMD Millipore Alice C. Evans Award both from the American Society for Microbiology and the Excellence in Teaching Award by Phi Beta Kappa. In 2015 she and Everett Peter Greenberg of the University of Washington were awarded the Shaw Prize in Life Science and Medicine "for elucidating the molecular mechanism of quorum sensing, a process whereby bacteria communicate with each other and which offers innovative ways to interfere with bacterial pathogens or to modulate the microbiome for health applications." In 2016, Bonnie Bassler was awarded The FASEB Excellence in Science Award, the Greengard prize, and the Max Planck Research Award. In 2016, she also became an elected member of the National Academy of Medicine. Bassler was awarded the Dickson Prize and the Ernst Schering Prize in March and September 2018 respectively.
- Ng, W. L., & Bassler, B. L. (2009). Bacterial quorum-sensing network architectures. Annual review of genetics, 43, 197-222.
- Bassler, B. L., & Losick, R. (2006). Bacterially speaking. Cell, 125(2), 237-246.
- Camilli, A., & Bassler, B. L. (2006). Bacterial small-molecule signaling pathways. Science, 311(5764), 1113-1116.
- Waters, C. M., & Bassler, B. L. (2005). Quorum sensing: cell-to-cell communication in bacteria. Annu. Rev. Cell Dev. Biol., 21, 319-346.
- Lenz, D. H., Mok, K. C., Lilley, B. N., Kulkarni, R. V., Wingreen, N. S., & Bassler, B. L. (2004). The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell, 118(1), 69-82.
- Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002). Structural identification of a bacterial quorum-sensing signal containing boron. Nature, 415(6871), 545.
- Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Reviews in Microbiology, 55(1), 165-199.
- Schauder, S., Shokat, K., Surette, M. G., & Bassler, B. L. (2001). The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule. Molecular microbiology, 41(2), 463-476.
- Surette, M. G., Miller, M. B., & Bassler, B. L. (1999). Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proceedings of the National Academy of Sciences, 96(4), 1639-1644.
- Bassler, B. L. (1999). How bacteria talk to each other: regulation of gene expression by quorum sensing. Current opinion in microbiology, 2(6), 582-587.
- Bassler, B. L., Wright, M., Showalter, R. E., & Silverman, M. R. (1993). Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Molecular microbiology, 9(4), 773-786.
- Staff. "Professor Bonnie L. Bassler ForMemRS". The Royal Society. Retrieved 2012-10-21.
- "Book of Members, 1780-2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 20, 2011.
- "Bonnie Bassler at Princeton".
- "MacArthur Foundation". www.macfound.org.
- "Princeton university news".
- "Princeton news".
- Ahmed, F. (2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. doi:10.1073/pnas.0705870105. PMC 2278219. PMID 18362352.
- "Bonnie L. Bassler, Ph.D." Howard Hughes Medical Institute. Retrieved May 20, 2011.
- Schauder, S.; Bassler, B. L. (2001). "The languages of bacteria". Genes & Development. 15 (12): 1468–80. doi:10.1101/gad.899601. PMID 11410527.
- "Special Recognitions 2008". World Cultural Council. Archived from the original on November 5, 2013. Retrieved August 19, 2013.
- "Elected Fellows". AAAS - The World's Largest General Scientific Society. 2016-10-21. Retrieved 2017-03-10.
- "Members | American Philosophical Society". www.amphilsoc.org. Retrieved 2017-03-10.
- "American Society for Microbiology". www.asm.org. Retrieved 2017-03-10.
- "National Science Board". National Science Board. Retrieved 2017-03-10.
- "The Nifty Fifty (times 2)". USA Science and Engineering Festival. 2010. Archived from the original on 2012-07-23. Retrieved 2012-10-20.
- USA Science & Engineering Festival's Nifty Fifty Archived 2011-06-29 at the Wayback Machine.
- "Eighth Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Bonnie Bassler of Princeton University".
- "Wiley Foundation Past winners".
- http://www.nasonline.org, National Academy of Sciences -. "Richard Lounsbery Award". www.nasonline.org. Retrieved 2017-03-10.
- L’Oréal Foundation (26 March 2012). "Bonnie Bassler, 2012 L'Oréal-UNESCO Awards Laureate for North America" – via YouTube.
- "2014 EMD Millipore Alice C. Evans Award Laureate". www.asm.org. Retrieved 2018-10-20.
- "Two Princeton professors to receive Phi Beta Kappa teaching awards". Princeton University. Retrieved 2018-10-20.
- "Shaw Laureates in 2015 in Life Science and Medicine: Announcement and Citation". Shaw Prize Foundation. Retrieved 2 June 2015.
- "Recipients and Award Lectures". faseb.org. Retrieved 2017-03-10.
- Alex; MacWade, ra; Editor, Assistant. "Molecular biologist Bonnie Bassler receives Rockefeller's Pearl Meister Greengard Prize | The Rockefeller University Benchmarks". Archived from the original on 2017-03-12. Retrieved 2017-03-10.
- "The Pearl Meister Greengard Prize - The Rockefeller University". greengardprize.rockefeller.edu. Retrieved 2017-03-10.
- "AAAS Fellow Bonnie Bassler wins 2016 Max Planck Research Award". American Association for the Advancement of Science. Retrieved 2018-10-20.
- "National Academy of Medicine Elects 80 New Members - National Academy of Medicine". National Academy of Medicine. 2016-10-17. Retrieved 2018-10-20.
- Webteam, University of Pittsburgh University Marketing Communications. "Bonnie Bassler, PhD". www.dicksonprize.pitt.edu. Retrieved 2018-10-20.
- "Ernst Schering Prize 2018 – Schering Stiftung". scheringstiftung.de. Retrieved 2018-10-20.
- Ng, Wai-Leung; Bassler, Bonnie L. (2009-12). "Bacterial Quorum-Sensing Network Architectures". Annual Review of Genetics. 43 (1): 197–222. doi:10.1146/annurev-genet-102108-134304. ISSN 0066-4197. PMC 4313539. PMID 19686078. Check date values in:
- Bassler, Bonnie L.; Losick, Richard (2006-04). "Bacterially Speaking". Cell. 125 (2): 237–246. doi:10.1016/j.cell.2006.04.001. ISSN 0092-8674. PMID 16630813. Check date values in:
- Camilli, Andrew; Bassler, Bonnie L. (2006-02-24). "Bacterial Small-Molecule Signaling Pathways". Science. 311 (5764): 1113–1116. doi:10.1126/science.1121357. ISSN 0036-8075. PMC 2776824. PMID 16497924.
- Waters, Christopher M.; Bassler, Bonnie L. (2005-11). "QUORUM SENSING: Cell-to-Cell Communication in Bacteria". Annual Review of Cell and Developmental Biology. 21 (1): 319–346. doi:10.1146/annurev.cellbio.21.012704.131001. ISSN 1081-0706. PMID 16212498. Check date values in:
- Lenz, Derrick H.; Mok, Kenny C.; Lilley, Brendan N.; Kulkarni, Rahul V.; Wingreen, Ned S.; Bassler, Bonnie L. (2004-07-09). "The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. ISSN 0092-8674. PMID 15242645.
- Chen, Xin; Schauder, Stephan; Potier, Noelle; Van Dorsselaer, Alain; Pelczer, István; Bassler, Bonnie L.; Hughson, Frederick M. (2002-01). "Structural identification of a bacterial quorum-sensing signal containing boron". Nature. 415 (6871): 545–549. doi:10.1038/415545a. ISSN 0028-0836. PMID 11823863. Check date values in:
- Miller, Melissa B.; Bassler, Bonnie L. (2001-10). "Quorum Sensing in Bacteria". Annual Review of Microbiology. 55 (1): 165–199. doi:10.1146/annurev.micro.55.1.165. ISSN 0066-4227. PMID 11544353. Check date values in:
- Schauder, Stephan; Shokat, Kevan; Surette, Michael G.; Bassler, Bonnie L. (2001-12-21). "The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule". Molecular Microbiology. 41 (2): 463–476. doi:10.1046/j.1365-2958.2001.02532.x. ISSN 0950-382X.
- Surette, Michael G.; Miller, Melissa B.; Bassler, Bonnie L. (1999-02-16). "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production". Proceedings of the National Academy of Sciences. 96 (4): 1639–1644. doi:10.1073/pnas.96.4.1639. ISSN 0027-8424. PMC 15544. PMID 9990077.
- Bassler, Bonnie L (1999-12). "How bacteria talk to each other: regulation of gene expression by quorum sensing". Current Opinion in Microbiology. 2 (6): 582–587. doi:10.1016/s1369-5274(99)00025-9. ISSN 1369-5274. Check date values in:
- Bassler, Bonnie L.; Wright, Miriam; Showalter, Richard E.; Silverman, Michael R. (1993-08). "Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence". Molecular Microbiology. 9 (4): 773–786. doi:10.1111/j.1365-2958.1993.tb01737.x. ISSN 0950-382X. Check date values in:
- Princeton University faculty webpage
- A Biologist's Listening Guide to Bacteria - All Things Considered interview
- Howard Hughes Medical Institute biography
- Nova Science Now Profile: Bonnie Bassler
- Bonnie Bassler at TED
- TED Talk: How bacteria "talk" (TED2009)
- Bonnie Bassler Seminar: Cell-Cell Communication
- Bonnie Bassler Online Talk: Tiny Conspiracies