Aaron Ciechanover

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Aaron Ciechanover
Aaron Ciechanover Speaking at the Technion, February 2018.jpg
Prof. Ciechanover speaking at the Technion, Israel, February 2018
Born (1947-10-01) October 1, 1947 (age 73)
NationalityIsraeli
Alma materHadassah Medical School M.S. 1971; M.D. 1974 Technion-Israel Institute of Technology D.Sc
Known forUbiquitin-mediated protein degradation
Spouse(s)Menucha Ciechanover
AwardsNobel Prize in Chemistry (2004)
ForMem, NAS
Scientific career
FieldsBiology
InstitutionsTechnion, Israel
NCKU, Taiwan

Aaron Ciechanover (/ɑːhəˈrn iˈhɑːnvɛər/ (About this soundlisten) AH-hə-ROHN chee-HAH-noh-vair; Hebrew: אהרן צ'חנובר‎; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.

Biography[edit]

Early life[edit]

Ciechanover was born in Haifa, Israel on 1 October 1947.[1] He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker.[2] His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s.

Education[edit]

He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. On a visit to New York in 1977, Ciechanover spent two hours in a meeting with Rabbi Menachem M. Schneerson who discussed the nature of his research with him. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984.

Recent[edit]

Ciechanover is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion. He is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences. In 2008, he was a visiting Distinguished Chair Professor at NCKU, Taiwan.

Nobel Prize[edit]

Ciechanover is one of Israel's first Nobel Laureates in Science, earning his Nobel Prize in 2004 for his work in ubiquitination. He is honored for playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.

Publications and lectures[edit]

  • Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
  • Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
  • Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
  • Hershko, A. and Ciechanover, A. (1998). THE UBIQUITIN SYSTEM. Biochem. 1998 67:1, 425-479
  • Ciechanover was an invited guest lecturer at the Yerevan State Medical University in Armenia in 2010.
  • He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.

Industry involvement[edit]

Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics, BioTheryX, Inc., and Haplogen, GmbH.[3]

Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.

Awards[edit]

See also[edit]

References[edit]

  1. ^ "Irwin Rose | American biochemist". Encyclopedia Britannica. Retrieved 2020-04-05.
  2. ^ "Archived copy". Archived from the original on 2013-06-21. Retrieved 2013-02-11.CS1 maint: archived copy as title (link)
  3. ^ [1]
  4. ^ "Israel Prize Official Site (in Hebrew) – Recipient's C.V."
  5. ^ "Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".
  6. ^ Aaron Ciechanover on Nobelprize.org Edit this at Wikidata
  7. ^ Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived 2005-12-19 at the Wayback Machine – A web article
  8. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  9. ^ "Sir Hans Krebs Medal to Harald Stenmark". Oslo University Hospital. Retrieved 16 December 2014.
  10. ^ "NCKU honors world class scientists, 2008".
  11. ^ "Welcome to The University of Cambodia (UC)". uc.edu.kh. Retrieved 2018-05-09.

External links[edit]