Aaron Ciechanover
| Aaron Ciechanover | |
|---|---|
 Prof. Ciechanover Speaking at the Technion, Israel, February 2018. | |
| Born |
October 1, 1947 Haifa, British Mandate of Palestine (now Israel) |
| Nationality | Israeli |
| Known for | Ubiquitin-mediated protein degradation |
| Spouse(s) | Menucha Ciechanover |
| Awards | Nobel Prize in Chemistry (2004) |
| Scientific career | |
| Fields | Biology |
Aaron Ciechanover (/ɑːhəˈroʊn 
listen) AH-hə-ROHN chee-HAH-noh-vair; Hebrew: אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.
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Biography[edit]
Ciechanover was born in Haifa, a year before the establishment of Israel. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker.[1] His family were Jewish immigrants from Poland before World War II.
He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. On a visit to New York in 1977, Ciechanover spent two hours in a meeting with Rabbi Menachem M. Schneerson who discussed the nature of his research with him. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981-1984. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.
Ciechanover is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences.
As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.
Ciechanover is an atheist and does not believe in an afterlife, but strongly Jewish culturally.[2]
He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.
https://pust.co/index.php/2016/05/07/nobel-laureates-and-european-prince-visit-pust/
Publications[edit]
- Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
- Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
- Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
Industry involvement[edit]
Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics and BioTheryX, Inc.
Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.
Awards[edit]
- In 2000, Ciechanover received the Albert Lasker Award for Basic Medical Research.
- In 2003, he was awarded the Israel Prize, for biology.[3][4]
- In 2004, he was awarded Nobel Prize in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation.[5][6] The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
- In 2006, he was awarded the Sir Hans Krebs Medal[7]
- In 2009, he was conferred an Honorary Doctorate in Science by the University of Cambodia[8]
See also[edit]
References[edit]
- ^ http://encyclopedia.jrank.org/articles/pages/5635/Ciechanover-Aaron-1947.html
- ^ J. (2013). 50 Renowned Academics Speaking About God (Part 3). Retrieved September 04, 2016, from https://www.youtube.com/watch?v=HHv__O8wvZI
- ^ "Israel Prize Official Site (in Hebrew) – Recipient's C.V."
- ^ "Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".
- ^ Nobel citation
- ^ Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived 2005-12-19 at the Wayback Machine. – A web article
- ^ "Sir Hans Krebs Medal to Harald Stenmark". Oslo University Hospital. Retrieved 16 December 2014.
- ^ "Welcome to The University of Cambodia (UC)". uc.edu.kh. Retrieved 2018-05-09.
External links[edit]
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Wikimedia Commons has media related to Aaron Ciechanover. |
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Italics indicate a Nobel Memorial Prize, i.e. not one of the original Prizes bequested by Alfred Nobel. |
2004 Nobel Prize laureates | ||
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| Chemistry |
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| Economic Sciences |
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| Literature |
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| Peace |
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| Physics |
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| Physiology or Medicine |
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- 1947 births
- Members of the European Molecular Biology Organization
- Living people
- Hebrew University of Jerusalem alumni
- Israeli atheists
- Israel Prize in biology recipients
- Israeli Nobel laureates
- Israeli biologists
- Jewish atheists
- Jews in Mandatory Palestine
- Nobel laureates in Chemistry
- EMET Prize recipients in the Life Sciences
- People from Haifa
- Israeli Jews
- Israeli people of Polish-Jewish descent
- Technion – Israel Institute of Technology faculty
- Members of the Pontifical Academy of Sciences
- Members of the Israel Academy of Sciences and Humanities
- Foreign Members of the Russian Academy of Sciences
- Foreign Members of the Chinese Academy of Sciences
- Recipients of the Albert Lasker Award for Basic Medical Research
- Members of the American Philosophical Society
- Members of the European Academy of Sciences and Arts
