Aaron Ciechanover
Aaron Ciechanover | |
|---|---|
 Prof. Ciechanover Speaking at the Technion, Israel, February 2018. | |
| Born | October 1, 1947 |
| Nationality | Israeli |
| Known for | Ubiquitin-mediated protein degradation |
| Spouse(s) | Menucha Ciechanover |
| Awards | Nobel Prize in Chemistry (2004) |
| Scientific career | |
| Fields | Biology |
Aaron Ciechanover (/ɑːhəˈroʊn tʃiˈhɑːnoʊvɛər/ (
listen) AH-hə-ROHN chee-HAH-noh-vair; Hebrew: אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.
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Biography[edit]
Ciechanover was born in Haifa, a year before the establishment of Israel. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker.[1] His family were Jewish immigrants from Poland before World War II.
He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. On a visit to New York in 1977, Ciechanover spent two hours in a meeting with Rabbi Menachem M. Schneerson who discussed the nature of his research with him. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981-1984. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.
Ciechanover is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences.
As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.
Ciechanover is an atheist and does not believe in an afterlife, but strongly Jewish culturally.[2]
Dr. Ciechanover was an invited guest lecturer at the Yerevan State Medical University in Armenia in 2010.
He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.
Publications[edit]
- Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
- Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
- Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
Industry involvement[edit]
Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics, BioTheryX, Inc., and Haplogen,GmbH.[1]
Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.
Awards[edit]
- In 2000, Ciechanover received the Albert Lasker Award for Basic Medical Research.
- In 2003, he was awarded the Israel Prize, for biology.[3][4]
- In 2004, he was awarded Nobel Prize in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation.[5][6] The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
- In 2006, he was awarded the Sir Hans Krebs Medal[7]
- In 2009, he was conferred an Honorary Doctorate in Science by the University of Cambodia[8]
See also[edit]
References[edit]
- ^ "Archived copy". Archived from the original on 2013-06-21. Retrieved 2013-02-11.CS1 maint: archived copy as title (link)
- ^ J. (2013). 50 Renowned Academics Speaking About God (Part 3). Retrieved September 04, 2016, from https://www.youtube.com/watch?v=HHv__O8wvZI
- ^ "Israel Prize Official Site (in Hebrew) – Recipient's C.V."
- ^ "Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".
- ^ Nobel citation
- ^ Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived 2005-12-19 at the Wayback Machine – A web article
- ^ "Sir Hans Krebs Medal to Harald Stenmark". Oslo University Hospital. Retrieved 16 December 2014.
- ^ "Welcome to The University of Cambodia (UC)". uc.edu.kh. Retrieved 2018-05-09.
External links[edit]
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Wikimedia Commons has media related to Aaron Ciechanover. |
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Scholia has an author profile for Aaron Ciechanover. |
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Italics indicate a Nobel Memorial Prize, i.e. not one of the original Prizes bequested by Alfred Nobel. |
2004 Nobel Prize laureates | ||
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| Chemistry |
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| Literature |
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| Physiology or Medicine |
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- 1947 births
- Members of the European Molecular Biology Organization
- Living people
- Hebrew University of Jerusalem alumni
- Israeli atheists
- Israel Prize in biology recipients
- Israeli Nobel laureates
- Israeli biologists
- Jewish atheists
- Jews in Mandatory Palestine
- Nobel laureates in Chemistry
- EMET Prize recipients in the Life Sciences
- People from Haifa
- Israeli Jews
- Israeli people of Polish-Jewish descent
- Technion – Israel Institute of Technology faculty
- Members of the Pontifical Academy of Sciences
- Members of the Israel Academy of Sciences and Humanities
- Foreign Members of the Russian Academy of Sciences
- Foreign members of the Chinese Academy of Sciences
- Recipients of the Albert Lasker Award for Basic Medical Research
- Members of the American Philosophical Society
- Members of the European Academy of Sciences and Arts
- Foreign associates of the National Academy of Sciences
