Aaron Ciechanover
Aaron Ciechanover | |
|---|---|
 Prof. Ciechanover speaking at the Technion, Israel, February 2018 | |
| Born | October 1, 1947 |
| Nationality | Israeli |
| Alma mater | Hadassah Medical School M.S. 1971; M.D. 1974 Technion-Israel Institute of Technology D.Sc |
| Known for | Ubiquitin-mediated protein degradation |
| Spouse(s) | Menucha Ciechanover |
| Awards | Nobel Prize in Chemistry (2004) ForMem, NAS |
| Scientific career | |
| Fields | Biology |
| Institutions | Technion, Israel NCKU, Taiwan |
Aaron Ciechanover (/ɑːhəˈroʊn tʃiˈhɑːnoʊvɛər/ (
listen) AH-hə-ROHN chee-HAH-noh-vair; Hebrew: אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.
Biography[edit]
Early life[edit]
Ciechanover was born in Haifa, Israel on 1 October 1947.[1] He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker.[2] His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s.
Education[edit]
He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. On a visit to New York in 1977, Ciechanover spent two hours in a meeting with Rabbi Menachem M. Schneerson who discussed the nature of his research with him. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984.
Recent[edit]
Ciechanover is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion. He is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences. In 2008, he was a visiting Distinguished Chair Professor at NCKU, Taiwan.
Nobel Prize[edit]
Ciechanover is one of Israel's first Nobel Laureates in Science, earning his Nobel Prize in 2004 for his work in ubiquitination. He is honored for playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.
Publications and lectures[edit]
- Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
- Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
- Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
- Hershko, A. and Ciechanover, A. (1998). THE UBIQUITIN SYSTEM. Biochem. 1998 67:1, 425-479
- Ciechanover was an invited guest lecturer at the Yerevan State Medical University in Armenia in 2010.
- He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.
Industry involvement[edit]
Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics, BioTheryX, Inc., and Haplogen, GmbH.[3]
Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.
Awards[edit]
- In 2000, Ciechanover received the Albert Lasker Award for Basic Medical Research.
- In 2003, he was awarded the Israel Prize, for biology.[4][5]
- In 2004, he was awarded the Nobel Prize in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation.[6][7] The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of cancer, muscular and neurological diseases, and immune and inflammatory responses.
- In 2005, he received the Golden Plate Award of the American Academy of Achievement.[8]
- In 2006, he was awarded the Sir Hans Krebs Medal.[9]
- In 2008. he was conferred Hon. DSc by NCKU Taiwan[10]
- In 2009, he was conferred an Honorary Doctorate in Science by the University of Cambodia.[11]
See also[edit]
References[edit]
- ^ "Irwin Rose | American biochemist". Encyclopedia Britannica. Retrieved 2020-04-05.
- ^ "Archived copy". Archived from the original on 2013-06-21. Retrieved 2013-02-11.CS1 maint: archived copy as title (link)
- ^ [1]
- ^ "Israel Prize Official Site (in Hebrew) – Recipient's C.V."
- ^ "Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".
- ^ Aaron Ciechanover on Nobelprize.org
- ^ Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived 2005-12-19 at the Wayback Machine – A web article
- ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
- ^ "Sir Hans Krebs Medal to Harald Stenmark". Oslo University Hospital. Retrieved 16 December 2014.
- ^ "NCKU honors world class scientists, 2008".
- ^ "Welcome to The University of Cambodia (UC)". uc.edu.kh. Retrieved 2018-05-09.
External links[edit]
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Wikimedia Commons has media related to Aaron Ciechanover. |
 |
Scholia has an author profile for Aaron Ciechanover. |
- Aaron Ciechanover on Nobelprize.org including the Nobel Lecture on December 8, 2004 Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting
- Website at the Technion
- A video interview with Aaron Ciechanover
- [2]
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Italics indicate a Nobel Memorial Prize, i.e. not one of the original Prizes bequested by Alfred Nobel. |
2004 Nobel Prize laureates | ||
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- 1947 births
- Living people
- Nobel laureates in Chemistry
- Israeli Nobel laureates
- Jewish Nobel laureates
- Nobel laureates affiliated with Missouri
- Members of the European Molecular Biology Organization
- Hebrew University of Jerusalem alumni
- Israeli atheists
- Israel Prize in biology recipients
- Israeli biologists
- Jewish atheists
- Jews in Mandatory Palestine
- EMET Prize recipients in the Life Sciences
- People from Haifa
- Israeli Jews
- Israeli people of Polish-Jewish descent
- Technion – Israel Institute of Technology faculty
- Members of the Pontifical Academy of Sciences
- Members of the Israel Academy of Sciences and Humanities
- Foreign Members of the Russian Academy of Sciences
- Foreign members of the Chinese Academy of Sciences
- Recipients of the Albert Lasker Award for Basic Medical Research
- Members of the American Philosophical Society
- Members of the European Academy of Sciences and Arts
- Foreign associates of the National Academy of Sciences