Eric Betzig

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Eric Betzig
Eric Betzig.jpg
Robert Eric Betzig[1]

(1960-01-13) January 13, 1960 (age 60)
Alma materCalifornia Institute of Technology
Cornell University
Known forNanoscopy, fluorescence microscopy
Scientific career
FieldsApplied physics
InstitutionsHoward Hughes Medical Institute
University of California, Berkeley
ThesisNear-field Scanning Optical Microscopy (1988)
Doctoral advisorAaron Lewis, Michael Isaacson
InfluencesWilliam E. Moerner

Robert Eric Betzig (born January 13, 1960) is an American physicist who works as a Professor of Physics and Professor Molecular and Cell biology at the University of California, Berkeley.[2][3][4] He is also a Senior Fellow at the Janelia Farm Research Campus in Ashburn, Virginia.[2][4][5]

Betzig has worked to develop the field of fluorescence microscopy and photoactivated localization microscopy. He was awarded the 2014 Nobel Prize in Chemistry for "the development of super-resolved fluorescence microscopy"[6] along with Stefan Hell and fellow Cornell alumnus William E. Moerner.[7]

Dual color localization microscopy SPDMphymod/super-resolution microscopy with GFP & RFP fusion proteins

Early life and education[edit]

Betzig was born in Ann Arbor, Michigan in 1960, the son of Robert Betzig, an engineer, and Helen Betzig. Aspiring to work in the aerospace industry, Betzig studied Physics at the California Institute of Technology and graduated with a BS degree in 1983. He then went on to study at Cornell University where he was advised by Aaron Lewis and Michael Isaacson. There he obtained an MS degree and a PhD degree in Applied and Engineering physics in 1985 and 1988, respectively. For his PhD he focused on developing high resolution optical microscopes that could see past the theoretical limit of .2 micrometers.[8][9][10]


Bell Laboratories[edit]

After receiving his doctorate, Betzig was hired by AT&T Bell Laboratories in the Semiconductor Physics Research Department in 1989. That year Betzig's colleague, William E. Moerner, developed the first optical microscope that could see past the .2 micrometer limit, known as the Abbe limit, but it could only function at temperatures near absolute zero. Betzig was awarded the William L. McMillan Award in 1992. Inspired by Moerner's research, he became the first person to image individual fluorescent molecules at room temperature while determining their positions to more than .2 micrometers in 1993. For this he received the William O. Baker Award for Initiatives in Research which was at the time, the National Academy of Sciences Award for Initiatives in Research.[8]

Ann Arbor Machine Company[edit]

In 1994, Betzig became frustrated with the academic community and the uncertainty of the corporate structure of Bell Laboratories causing him to leave both. He spent some years as a house husband before reentering the workforce.[11] At his father's wish, in 1996 he took up the position of vice president of research and development at Ann Arbor Machine Company, then owned by the Betzig family.[7] Here he developed Flexible Adaptive Servohydraulic Technology (FAST) and after spending millions of dollars on development, sold a total of two devices which did not allow him to achieve commercial success.[8][9][11][12]

Return to academia[edit]

In 2002, Betzig then returned to the field of microscopy by founding a firm known as New Millennium Research, in Okemos, Michigan. Inspired by the work of Mike Davidson and his fluorescent proteins, he developed photoactivated localization microscopy (PALM), a method of controlling fluorescent proteins using pulses of light to create images of a higher resolution than previously thought possible. In the living room of his old Bell Labs collaborator, Harald Hess, they developed the first optical microscope based on this technology. They built their first prototype in less than two months, gathering widespread attention. In October of that year, Janelia hired him, but his lab was still under construction at the time.[9]

In early 2006, he formally joined the Howard Hughes Medical Institute's Janelia Farm Research Campus as a group leader to work on developing super high-resolution fluorescence microscopy techniques. He used this technique to study the division of cells in human embryos.[7][13] In 2010, he was offered the Max Delbruck Prize, but he declined it allowing Xiaowei Zhuang to receive the award. In 2014, Betzig was jointly awarded the Nobel Prize in Chemistry along with Stefan Hell and William E. Moerner.[6][9][14]

In the summer of 2017, Betzig joined the faculty of UC Berkeley with a joint appointment at Lawrence Berkeley National Laboratory.[15]


  1. ^ "Eighty-Ninth Annual Commencement – California Institute of Technology" (PDF). California Institute of Technology. June 10, 1983. Retrieved October 11, 2014.
  2. ^ a b "Eric Betzig | UC Berkeley Physics". Retrieved 2019-07-18.
  3. ^ "Eric Betzig | Research UC Berkeley". Retrieved 2019-07-18.
  4. ^ a b "Eric Betzig". Retrieved 2019-07-18.
  5. ^ "Eric Betzig, PhD". Howard Hughes Medical Institute. Retrieved 2014-10-08.
  6. ^ a b "The Nobel Prize in Chemistry 2014". Nobel Media AB. 2014-10-08. Retrieved 2014-10-08.
  7. ^ a b c "Eric Betzig Wins 2014 Nobel Prize in Chemistry". HHMI News. 2014-10-08. Retrieved 2014-10-08.
  8. ^ a b c "Eric Betzig". Janelia Farm Research Campus. Retrieved 2014-10-08.
  9. ^ a b c d Feltman, Rachel (October 8, 2014). "Nobel chemistry laureate's twisting path to molecular microscope breakthrough". Washington Post. Retrieved 19 August 2015.
  10. ^ Betzig, Robert Eric (1988). Nondestructive optical imaging of surfaces with 500 angstrom resolution (Ph.D.). Cornell University. OCLC 79223216 – via ProQuest.
  11. ^ a b Timmer, John (April 10, 2015). "Quitting + failures + a microscope in the living room = Nobel Prize". ars technicia. Retrieved 19 August 2015.
  12. ^ Gewin, Virginia (2006). "Eric Betzig, group leader, Janelia Farm Research Campus, Howard Hughes Medical Institute, Leesburg, Virginia". Nature. 440 (7083): 578. doi:10.1038/nj7083-578a.
  13. ^ Feltman, Rachel (October 8, 2014). "The Nobel Prize in chemistry goes to three men who revolutionized microscopy". Washington Post. Retrieved 19 August 2015.
  14. ^ "EricBetzig: Chemist and Nobel Prize". Starmus. Retrieved 19 August 2015.
  15. ^ Israel, Brett (27 September 2016). "Nobel Prize winner to join UC Berkeley faculty". Berkeley News. Retrieved 28 September 2016.

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