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In ancient Sanskrit writings, the Brahmastra (Sanskrit: ब्रह्मास्त्र, IAST: Brahmāstra) was a weapon created by Brahma. The Brahmashirsha astra and Brahmanda astra were similar weapons, created to be even more powerful.
Since Brahma is considered the Creator in Sanatana Dharma, it is believed by Hindus that Brahmastra was created by him for the purpose of upholding Dharma and Satya, to be used by anyone who wished to destroy an enemy who would also happen to be a part of his (Brahma's) creation. The target, when hit by Brahmastra, would be utterly destroyed.
In the Ramayana, a Brahmastra is used by Shri Rama several times: once against Jayanta when he hurt Sita, against Mareecha in their last encounter, and finally the Brahmastra was used in the last battle with the Asura emperor Ravana.
In some texts it is called Brahma-dhanda astra, the weapon created by Saptarishi's to counter any weapon ever created, even that of Trimurti's. The rishi of this weapon is Para Brahman. It is said to be the most difficult astra to obtain. Capable of destroying entire multiverse in a blink of an eye. Vishvamitra used all kinds of divine weapons against sage Vashistha, even Pashupatastra, but the Brahma-dhanda astra of Vashistha neutralized and swallowed all astra (weapon) of Vishwamitra proving that Brahma-dhanda astra is the most powerful of all astra's.