CDKN2D

CDKN2D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BD8, 1BI8
Identifiers
Aliases	CDKN2D, INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D
External IDs	OMIM: 600927; MGI: 105387; HomoloGene: 36081; GeneCards: CDKN2D; OMA:CDKN2D - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,569,059 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,202,703 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; amygdala; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; caudate nucleus;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; atrium; ; thymus; ; fetal liver hematopoietic progenitor cell; ; medial ganglionic eminence; ; saccule; ; endocardial cushion; ; human fetus; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol; cyclin D2-CDK4 complex;
Biological process	DNA synthesis involved in DNA repair; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to vitamin D; response to retinoic acid; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of cell growth; cell cycle; negative regulation of phosphorylation; response to UV; autophagic cell death; negative regulation of cell population proliferation; hearing; negative regulation of cell cycle G1/S phase transition; G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1032
	12581
	ENSG00000129355
	ENSMUSG00000096472
	P55273
	Q60773
	NM_079421; NM_001800
	NM_009878
	NP_001791; NP_524145
	NP_034008
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.^[5]^[6]

Template:PBB Summary

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096472 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754.
^ "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)".

External links

CDKN2D human gene location in the UCSC Genome Browser.
CDKN2D human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000096472 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8575754-5] Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754.

[entrez-6] "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)".

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References

Further reading

External links