From Wikipedia, the free encyclopedia
Jump to: navigation, search
Colestilan skeletal.svg
Systematic (IUPAC) name
2-(chloromethyl)oxirane 2-methyl-1H-imidazole copolymer
Clinical data
Trade names BindRen
AHFS/ International Drug Names
  • B
Legal status
  • (Prescription only)
Routes of
Pharmacokinetic data
Bioavailability Not absorbed
Protein binding NA
Metabolism Not absorbed
Excretion Gut
CAS Number 95522-45-5 YesY
ATC code V03AE06
PubChem CID: 65840
KEGG D01934 YesY
Chemical data
Formula (C4H5ClN2)m(C3H6O)n
 N (what is this?)  (verify)

Colestilan (INN, trade name BindRen) is a medication that acts as a phosphate binder[1] and bile acid sequestrant.[2]

Clinical use[edit]

Colestilan is used for the treatment of hyperphosphataemia (too high phosphate concentrations in the blood serum) in patients undergoing dialysis, including peritoneal dialysis.[1][3]


Colestilan is contraindicated in patients with bowel obstruction.[3]


The substance can inhibit the resorption of other drugs, as well as fat soluble vitamins (A, D, E, K) and folate, from the gut.[1] Resulting lower blood levels can be clinically problematic with immunosuppressant and antiepileptic drugs.[3]

Adverse effects[edit]

Adverse effects include gastrointestinal problems such as constipation, as well as vitamin and calcium deficiency. Vitamin K deficiency sometimes causes gastrointestinal bleeding.[1][3]

Chemistry and mechanism of action[edit]

Colestilan is a cross-linked copolymer of 2-methylimidazole and epichlorohydrin and works as an anion exchanger resin with affinity to phosphate, bile acid anions and urate. It binds these anions in the gut and removes them from the enterohepatic circulation. Colestilan is not absorbed from the gut, but is excreted together with the bound anions.[1]

2-methyl-1H-imidazole (left) and epichlorohydrin (right)


  1. ^ a b c d e A. Klement (11 November 2013). "Dialysepflichtig – weniger Phosphat mit BindRen". Österreichische Apothekerzeitung (in German) (23/2013): 28f. 
  2. ^ Handelsman, Y. (2011). "Role of Bile Acid Sequestrants in the Treatment of Type 2 Diabetes". Diabetes Care 34: S244–S250. doi:10.2337/dc11-s237. PMID 21525463. 
  3. ^ a b c d Haberfeld, H, ed. (2013). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.