Acipimox

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Acipimox
Skeletal formula
Ball-and-stick model
Systematic (IUPAC) name
5-carboxy-2-methyl-1-oxidopyrazin-1-ium
Clinical data
Trade names Olbetam
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
Identifiers
CAS Registry Number 51037-30-0 YesY
ATC code C10AD06
PubChem CID: 5310993
IUPHAR/BPS 1596
ChemSpider 4470534 YesY
UNII K9AY9IR2SD YesY
KEGG D07190 YesY
ChEMBL CHEMBL345714 YesY
Chemical data
Formula C6H6N2O3
Molecular mass 154.124 g/mol
 YesY (what is this?)  (verify)

Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL cholesterol, which leads indirectly to a modest reduction in LDL and increase in HDL cholesterol. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with prostaglandin D2), palpitations, and gastrointestinal disturbances. Flushing can be reduced by taking aspirin 20 to 30 minutes before taking acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.