Extracellular matrix protein 1

ECM1
Identifiers
Aliases	ECM1, URBWD, extracellular matrix protein 1
External IDs	OMIM: 602201 MGI: 103060 HomoloGene: 3260 GeneCards: ECM1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,513,789 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,646,881 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; oral cavity; ; gallbladder; ; amniotic fluid; ; body of tongue; ; epithelium of esophagus; ; corpus epididymis; ; vagina; ; periodontal fiber; ; vena cava;
	Top expressed in
	esophagus; ; adrenal gland; ; urinary bladder; ; lip; ; zone of skin; ; white adipose tissue; ; kidney; ; liver; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-2 receptor binding; signal transducer activity; protease binding; protein C-terminus binding; protein binding; enzyme binding; laminin binding;
Cellular component	extracellular matrix; extracellular exosome; extracellular region; platelet dense granule lumen; extracellular space;
Biological process	regulation of T cell migration; negative regulation of peptidase activity; negative regulation of bone mineralization; positive regulation of endothelial cell proliferation; ossification; regulation of bone mineralization; regulation of transcription by RNA polymerase II; biomineral tissue development; negative regulation of cytokine-mediated signaling pathway; positive regulation of angiogenesis; angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB signaling; inflammatory response; regulation of type 2 immune response; platelet degranulation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1893
	13601
	ENSG00000143369
	ENSMUSG00000028108
	Q16610
	Q61508
	NM_022664; NM_001202858; NM_004425
	NM_001252653; NM_007899; NM_001355070
	NP_001189787; NP_004416; NP_073155
	NP_001239582; NP_031925; NP_001341999
	Wikidata
View/Edit Human	View/Edit Mouse

Extracellular matrix protein 1 is a protein that in humans is encoded by the ECM1 gene.^[5]^[6]^[7]

Template:PBB Summary

Diseases

ECM1 is implicated in breast cancer, thyroid cancer, hepatocellular carcinoma, and other cancers, and also in lipoid proteinosis and ulcerative colitis^[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,^[9]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143369 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028108 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smits P, Ni J, Feng P, Wauters J, Van Hul W, Boutaibi ME, Dillon PJ, Merregaert J (Jan 1998). "The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization". Genomics. 45 (3): 487–95. doi:10.1006/geno.1997.4918. PMID 9367673.
^ Johnson MR, Wilkin DJ, Vos HL, Ortiz de Luna RI, Dehejia AM, Polymeropoulos MH, Francomano CA (May 1998). "Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21". Matrix Biol. 16 (5): 289–92. doi:10.1016/S0945-053X(97)90017-2. PMID 9501329.
^ "Entrez Gene: ECM1 extracellular matrix protein 1".
^ http://atlasgeneticsoncology.org/Genes/ECM1ID40398ch1q21.html
^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

Extracellular matrix protein 1

Diseases

See also

References

Further reading