Flavonoid 3'-monooxygenase

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flavonoid 3'-monooxygenase
EC number
CAS number 85340-98-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a flavonoid 3'-monooxygenase (EC is an enzyme that catalyzes the chemical reaction[1]

a flavonoid + NADPH + H+ + O2 a 3'-hydroxyflavonoid + NADP+ + H2O

The 4 substrates of this enzyme are flavonoid, NADPH, H+, and O2, whereas its 3 products are 3'-hydroxyflavonoid, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating). Other names in common use include flavonoid 3'-hydroxylase, flavonoid 3-hydroxylase (erroneous), NADPH:flavonoid-3'-hydroxylase, and flavonoid 3-monooxygenase (erroneous). This enzyme participates in flavonoid biosynthesis.


  1. ^ Forkmann, G.; Heller, W.; Grisebach, H. (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases". Z. Naturforsch. C: Biosci. 35: 691–695.