SGLT2 inhibitor

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SGLT2 inhibitors, also called gliflozins or flozins, are a class of medications that modulate sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption of glucose in the kidney and therefore lower blood sugar.[1] They act by inhibiting sodium-glucose transport protein 2 (SGLT2). SGLT2 inhibitors are used in the treatment of type II diabetes mellitus (T2DM). Apart from blood sugar control, gliflozins have been shown to provide significant cardiovascular benefit in patients with type II diabetes (T2DM).[2][3] Several medications of this class have been approved or are currently under development.[4] In studies on canagliflozin, a member of this class, the medication was found to enhance blood sugar control as well as reduce body weight and systolic and diastolic blood pressure.[5]

Medical uses[edit]

The 2022 ADA standards of medical care in diabetes include SGLT2 inhibitors as a first line pharmacological therapy for type 2 diabetes (usually together with metformin), specifically in patients with chronic kidney disease, cardiovascular disease or heart failure.[6]

A systematic review and network meta-analysis comparing SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors demonstrated that use of SGLT2 inhibitors was associated with a 20% reduction in death compared with placebo or no treatment.[7] Another systematic review discussed the mechanisms by which SGLT-2 inhibitors improve cardio-renal function in patients with type 2 diabetes mellitus, emphasizing the impacts in improving neural tone.[8]

Two reviews have concluded that SGLT2 inhibitors benefit patients with atherosclerotic major adverse cardiovascular events (MACE).[9][10] One of those studies defined MACE as the composite of myocardial infarction, stroke, or cardiovascular death.[9]

Adverse effects[edit]

Genital infections seem to be the most common adverse effect of gliflozins. In clinical trials fungal infections, urinary tract infections and osmotic diuresis were higher in patients treated with gliflozins.[citation needed]

In May 2015, the FDA issued a warning that gliflozins can increase risk of diabetic ketoacidosis (DKA).[11] By reducing glucose blood circulation, gliflozins cause less stimulation of endogenous insulin secretion or lower dose of exogenous insulin that results in diabetic ketoacidosis. They can specifically cause euglycemic DKA (euDKA, DKA where the blood sugar is not elevated) because of the renal tubular absorption of ketone bodies.[12] A particularly high risk period for ketoacidosis is the perioperative period. SGLT2 inhibitors may need to be discontinued before surgery, and only recommended when someone is not unwell, is adequately hydrated and able to consume a regular diet.[13]

In September 2015, the FDA issued a warning related to canagliflozin (Invokana) and canagliflozin/metformin (Invokamet) due to decreased bone mineral density and therefore increased risk of bone fractures. Using gliflozins in combination therapy with metformin can lower the risk of hypoglycemia compared to other T2DM such as sulfonylureas and insulin.[11]

Increased risk of lower limb amputation is associated with canagliflozin but further data is needed to confirm this risk associated with different gliflozins.[14] A European Medicines Agency review concluded that there is a potential increased risk of lower limb amputation (mostly affecting the toes) in people taking canagliflozin, dapagliflozin and empagliflozin.[15]

In August 2018, the FDA issued a warning of an increased risk of Fournier gangrene in patients using SGLT2 inhibitors.[16] The absolute risk is considered very low.[17]

To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery.[18]

Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing.[18]

In the FDA Adverse Event Reporting System an increase was reported in events of acute kidney injury associated with SGLT2 inhibitors,[19][20] though data from clinical trials actually showed a reduction in such events with SGLT-2 treatment.[21]


Interactions are important for SGLT2 inhibitors because most T2DM patients are taking many other medications. Gliflozins appear to increase the diuretic effect of thiazides, loop diuretics and related diuretics and may increase the risk of dehydration and hypotension.[22] It is important to adjust the dose of antidiabetics if the treatment is combination therapy to avoid hypoglycemia. For example, interactions with sulfonylureas have led to severe hypoglycemia presumably due to cytochrome P450.[23]

A study has shown that it is safe to consume dapagliflozin along with pioglitazone, metformin, glimepiride, or sitagliptin and dose adjustment is unnecessary for either medication.[24] It is unlikely that food intake has clinical meaningful impact on the efficacy of dapagliflozin, therefore it can be administered without regard to meals.[24][25]


These are the known members of the gliflozin class:

  • Canagliflozin was the first SGLT2 inhibitor to be approved for use in the United States. It was approved in March 2013, under the brand name Invokana and it was also marketed throughout the EU under the same name.[26][27]
  • Dapagliflozin is the first SGLT2 inhibitor approved anywhere in the world by the EU in 2012.[28] It was approved for use in the United States under the brand name Farxiga by the Food and Drug Administration in January 2014.[29] the first oral treatment in combination with insulin to treat type 1 diabetes mellitus in UK and EU.
  • Empagliflozin, approved in the United States in August 2014, under the brand name Jardiance by Boehringer Ingelheim.[30] Of the gliflozins, empagliflozin and tofogliflozin have the highest specificity for SGLT2 inhibition.[1] This oral medicine for type 2 diabetes has been shown to reduce the risk of cardiovascular death.[31]
  • Ertugliflozin was approved in the United States under the brand name Steglatro in December 2017.[32]
  • Ipragliflozin, produced by the Japanese company Astellas Pharma Inc. under the brand name Suglat, approved in Japan January 2014.[33][34]
  • Luseogliflozin was approved in Japan March 2014 under the brand name Lusefi and was developed by Taisho Pharmaceutical.[35]
  • Remogliflozin etabonate was commercially launched first in India by Glenmark in May 2019.
  • Sergliflozin etabonate discontinued after Phase II trials.[36]
  • Sotagliflozin is a dual SGLT1/SGLT2 inhibitor in phase III trials under the brand name Zynquista. Developed by Lexicon pharmaceuticals. It was planned to be the first oral treatment in combination with insulin to treat type 1 diabetes mellitus.[37] The Food and Drug Administration refused its approval for use in combination with insulin for the treatment of type 1 diabetes.[38][39]
  • Tofogliflozin was approved in Japan in March 2014, under the brand names Apleway and Deberza developed by Sanofi and Kowa Pharmaceutical.[40]

Mechanism of action[edit]

Sodium Glucose cotransporters (SGLTs) are proteins that occur primarily in the kidneys and play an important role in maintaining glucose balance in the blood.[41] SGLT1 and SGLT2 are the two most known SGLTs of this family. SGLT2 is the major transport protein and promotes reabsorption from the glomerular filtration glucose back into circulation and is responsible for approximately 90% of the kidney's glucose reabsorption.[1] SGLT2 is mainly expressed in the kidneys on the epithelial cells lining the first segment of the proximal convoluted tubule. By inhibiting SGLT2, gliflozins prevent the kidneys' reuptake of glucose from the glomerular filtrate and subsequently lower the glucose level in the blood and promote the excretion of glucose in the urine (glucosuria).[42][43]

Reabsorption of glucose in the nephron

The mechanism of action on a cellular level is not well understood. Work is underway to define this mechanism as a prodiuretic with great promise. However, it has been shown that binding of different sugars to the glucose site affects the orientation of the aglycone in the access vestibule. So when the aglycone binds it affects the entire inhibitor. Together these mechanisms lead to a synergistic interaction. Therefore, variations in the structure of both the sugar and the aglycone are crucial for the pharmacophore of SGLT inhibitors.[44]

Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases with higher level of glucose in the blood circulation. Therefore, dapagliflozin reduces the blood glucose concentration with a mechanism that is independent of insulin secretion and sensitivity, unlike many other antidiabetic medications. Functional pancreatic β-cells are not necessary for the activity of the medication so it is convenient for patients with diminished β-cell function.[42][43]

Sodium and glucose are co-transported by the SGLT-2 protein into the tubular epithelial cells across the brush-border membrane of the proximal convoluted tubule. This happens because of the sodium gradient between the tubule and the cell and therefore provides a secondary active transport of glucose. Glucose is later reabsorbed by passive transfer of endothelial cells into the interstitial glucose transporter protein.[42][43][45]

TABLE 1: Where are SGLTs expressed?
SGLT Expressed in human tissues
SGLT1 Intestine, trachea, kidney, heart, brain, testis, prostate
SGLT2 Kidney, brain, liver, thyroid, muscle, heart

Ratios of activity between SGLT1 and SGLT2 may be helpful in defining expression.


The elimination half-life, bioavailability, protein binding, the blood concentration Cmax at time tmax, and other pharmacokinetic parameters of various medications of this class are present in table 2. These medications are excreted in the urine as inactive metabolites.[45][46][47][48]

Name of drug Bioavailability Protein binding tmax (hours) t1/2 (hours) Cmax SGLT2 selectivity over SGLT1
Canagliflozin 65% (300 mg dose) 99% 1–2 10.6 (100 mg dose); 13.1 (300 mg dose) 1096 ng/mL (100 mg dose); 3480 ng/mL (300 mg dose) 250 fold
Dapagliflozin 78% 91% 1–1.5 12.9 79.6 ng/mL (5 mg dose); 165.0 ng/mL (10 mg dose) 1200 fold
Empagliflozin 90–97% (mice); 89% (dogs); 31% (rats) 86.20% 1.5 13.2 (10 mg dose); 13.3h (25 mg dose) 259nmol/L (10 mg dose); 687nmol/L (25 mg dose) 2500 fold
Ertugliflozin 70-90% 95% 0.5-1.5 11-17 268 ng/mL (15 mg dose) 2000 fold
Ipragliflozin (50 mg) 90% 96.30% 1 15–16 (50 mg dose) 975 ng/mL 360 fold
Luseogliflozin 35.3% (male rats); 58.2% (female rats); 92.7% (male dogs) 96.0–96.3% 0.625±0.354 9.24±0.928 119±27.0 ng/mL 1650 fold
Tofogliflozin (10 mg) 97.50% 83% 0.75 6.8 489 ng/mL 2900 fold
  • Cmax: Maximum serum concentration that drug achieves in body after the drug has been and administrated
  • tmax: Time to achieve maximum plasma concentration
  • t1/2: Biological half-life

In studies that were made on healthy people and people with type II diabetes mellitus, who were given dapagliflozin in either single ascending dose (SAD) or multiple ascending dose (MAD) showed results that confirmed a pharmacokinetic profile of the medication. With dose-dependent concentrations the half-life is about 12–13 hours, Tmax 1–2 hours and it is protein-bound, so the medication has a rapid absorption and minimal excretion by the kidney.[24]

Dapagliflozin disposition is not evidently affected by BMI or body weight, therefore the pharmacokinetic findings are expected to be applicable to patients with a higher BMI. Dapagliflozin resulted in dose-dependent increases excretions in urinary glucose, up to 47g/d following single-dose administration, which can be expected from its mechanism of action, dapagliflozin.[25]

In some long term clinical studies that have been made on dapagliflozin, dapagliflozin was associated with a decrease in body weight which was statistically superior compared to placebo or other active comparators. It is primarily associated with caloric rather than fluid loss.[25][45]

In contrast with other anti-hyperglycemic diabetes medications, SGLT2 inhibitors enhance, rather than suppress, gluconeogenesis and ketogenesis.[50] Because SGLT2 inhibitors activate sirtuin 1 (and thus PGC-1α and FGF21), they are more cardioprotective than the other medications used to treat diabetes.[50]

Structure-activity relationship[edit]

The structure-activity relationship (SAR) of gliflozins is not fully understood.

The most common gliflozins are dapagliflozin, empagliflozin and canagliflozin. The differences in the structures is relatively small. The general structure includes a glucose sugar with an aromatic group in the β-position at the anomeric carbon. In addition to the glucose sugar moiety and the β-isomeric aryl substituent the aryl group is composed of a diarylmethylene structure.

The synthesis of Gliflozins involves three general steps. The first one is the construction of the aryl substituent, the next one is the introduction of the aryl moiety onto the sugar or glucosylation of the aryl substituent and the last one the deprotection and modification of the arylated anomeric center of the sugar.[51]

Phlorizin was the first type of gliflozin and it was non-selective against SGLT2/SGLT1. It is a natural O-aryl glycoside composed of a d-glucose and an aromatic ketone.[52] However Phlorizin is very unstable, it is rapidly degraded by glucosidases in the small intestines, so it can not be used as an oral administration medication to treat diabetes. Structural modifications have been made to overcome this instability problem. The most efficient way was to conjugate aryl moiety with glucose moiety since C-glucosides are more stable in the small intestines than O-glucoside derivatives (C-C bond instead of C-O-C bond).[53]


In the sugar analogues of dapagliflozin, the β-C series are more active than α-C series so it is critical that the β-configuration is at C-1 for the inhibitory activity.[54] Both dapagliflozin and empagliflozin contain a chlorine (Cl) atom in their chemical structure. Cl is a halogen and it has a high electronegativity. This electronegativity withdraws electrons off the bonds and therefore it reduces the metabolism. The Cl atom also reduces the IC50 value of the medication so the medication has better activity. The carbon-fluorine bond (C-F) has also has a veryl low electron density.[55]


For example, in the chemical structure of canagliflozin a fluorine atom is connected to an aromatic ring then the compound is more stable and the metabolism of the compound is reduced. Empagliflozin contains a tetrahydrofuran ring but not canagliflozin nor dapagliflozin.[56]


In the development of gliflozins the distal ring contains a thiophene ring instead of an aromatic ring. However the final chemical structures of the marketing gliflozins does not contain this thiophene ring.[57]

Alternative pharmacological actions[edit]

SGLT2 inhibitors increase circulating ketone body concentrations.[58] The cardioprotective effects of SGLT2 inhibitors have been attributed to the elevated ketone levels.[59]

Gliflozins have been posited to exhibit protective effects on the heart, liver, kidneys, anti‐hyperlipidemic, anti‐atherosclerotic, anti‐obesity, anti‐neoplastic effects in in vitro, pre‐clinical, and clinical studies. Pleiotropic effects of this class have been attributed to a variety of its pharmacodynamic actions such as natriuresis, hemoconcentration, deactivation of renin-angiotensin-aldosterone system, ketone body formation, alterations in energy homeostasis, glycosuria, lipolysis, anti‐inflammatory, and antioxidative actions.[60][3]


Phlorizin is a molecule with SGLT inhibiting properties, and served an important role in the development of the gliflozin class of medications.


  1. ^ a b c Shubrook, Jay; Baradar-Bokaie, Babak; Adkins, Sarah (2015). "Empagliflozin in the treatment of type 2 diabetes: Evidence to date". Drug Design, Development and Therapy. 9: 5793–803. doi:10.2147/DDDT.S69926. PMC 4634822. PMID 26586935.
  2. ^ Usman, Muhammad Shariq; Siddiqi, Tariq Jamal; Memon, Muhammad Mustafa; Khan, Muhammad Shahzeb; Rawasia, Wasiq Faraz; Talha Ayub, Muhammad; Sreenivasan, Jayakumar; Golzar, Yasmeen (2018). "Sodium-glucose co-transporter 2 inhibitors and cardiovascular outcomes: A systematic review and meta-analysis". European Journal of Preventive Cardiology. 25 (5): 495–502. doi:10.1177/2047487318755531. PMID 29372664. S2CID 3557967.
  3. ^ a b Bonora BM, Avogaro A, Fadini GP (2020). "Extraglycemic Effects of SGLT2 Inhibitors: A Review of the Evidence". Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13: 161–174. doi:10.2147/DMSO.S233538. PMC 6982447. PMID 32021362.
  4. ^ Scheen, André J. (2014). "Pharmacodynamics, Efficacy and Safety of Sodium–Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus". Drugs. 75 (1): 33–59. doi:10.1007/s40265-014-0337-y. PMID 25488697. S2CID 9350259.
  5. ^ Haas, B.; Eckstein, N.; Pfeifer, V.; Mayer, P.; Hass, M D S. (2014). "Efficacy, safety and regulatory status of SGLT2 inhibitors: Focus on canagliflozin". Nutrition & Diabetes. 4 (11): e143. doi:10.1038/nutd.2014.40. PMC 4259905. PMID 25365416.
  6. ^ Retrieved 2022-09-23. {{cite web}}: Missing or empty |title= (help)
  7. ^ Zheng, Sean L.; Roddick, Alistair J.; Aghar-Jaffar, Rochan; Shun-Shin, Matthew J.; Francis, Darrel; Oliver, Nick; Meeran, Karim (2018). "Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors with All-Cause Mortality in Patients with Type 2 Diabetes". JAMA. 319 (15): 1580–1591. doi:10.1001/jama.2018.3024. PMC 5933330. PMID 29677303.
  8. ^ Nashawi, Mouhamed; Sheikh, Omar; Battisha, Ayman; Ghali, Abdullah; Chilton, Robert (May 2021). "Neural tone and cardio-renal outcomes in patients with type 2 diabetes mellitus: a review of the literature with a focus on SGLT2 inhibitors". Heart Failure Reviews. 26 (3): 643–652. doi:10.1007/s10741-020-10046-w. ISSN 1573-7322. PMID 33169337. S2CID 226285893.
  9. ^ a b Zelniker TA, Wiviott SD, abatine MS (2019). "SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials". The Lancet. 393 (10166): 31–39. doi:10.1016/S0140-6736(18)32590-X. PMID 30424892. S2CID 53277899.
  10. ^ Xu D, Chandler O, Xiao H (2021). "Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2i) as a Primary Preventative Agent in the Healthy Individual: A Need of a Future Randomised Clinical Trial?". Frontiers in Medicine. 8: 712671. doi:10.3389/fmed.2021.712671. PMC 8419219. PMID 34497814.
  11. ^ a b Hsia, Daniel S.; Grove, Owen; Cefalu, William T. (2016). "An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus". Current Opinion in Endocrinology, Diabetes and Obesity. 24 (1): 73–79. doi:10.1097/MED.0000000000000311. PMC 6028052. PMID 27898586.
  12. ^ Isaacs, Michelle; Tonks, Katherine T.; Greenfield, Jerry R. (2017). "Euglycaemic diabetic ketoacidosis in patients using sodium-glucose co-transporter 2 inhibitors". Internal Medicine Journal. 47 (6): 701–704. doi:10.1111/imj.13442. PMID 28580740. S2CID 4091595.
  13. ^ Milder, D. A.; Milder, T. Y.; Kam, P. C. A. (August 2018). "Sodium-glucose co-transporter type-2 inhibitors: pharmacology and peri-operative considerations". Anaesthesia. 73 (8): 1008–1018. doi:10.1111/anae.14251. PMID 29529345.
  14. ^ Khouri, Charles; Cracowski, Jean-Luc; Roustit, Matthieu (2018). "SGLT-2 inhibitors and the risk of lower-limb amputation: Is this a class effect?". Diabetes, Obesity and Metabolism. 20 (6): 1531–1534. doi:10.1111/dom.13255. PMID 29430814. S2CID 3873882.
  15. ^ "SGLT2 inhibitors: information on potential risk of toe amputation to be included in prescribing information". European Medicines Agency. 4 May 2017.
  16. ^ "FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes". Center for Drug Evaluation and Research. 7 September 2018. p. Drug Safety and Availability. Retrieved 16 April 2019.
  17. ^ Bardia, Amit; Wai, Mabel; Fontes, Manuel L. (February 2019). "Sodium-glucose cotransporter-2 inhibitors: an overview and perioperative implications". Current Opinion in Anesthesiology. 32 (1): 80–85. doi:10.1097/ACO.0000000000000674. PMID 30531609. S2CID 54471240.
  18. ^ a b "FDA revises labels of SGLT2 inhibitors for diabetes to include warning". U.S. Food and Drug Administration. 19 March 2020. Retrieved 6 June 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  19. ^ Research, Center for Drug Evaluation and (2019-02-09). "FDA Drug Safety Communication: FDA strengthens kidney warnings for diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR)". FDA.
  20. ^ Perlman, A.; Heyman, S. N.; Matok, I.; Stokar, J.; Muszkat, M.; Szalat, A. (2017-12-01). "Acute renal failure with sodium-glucose-cotransporter-2 inhibitors: Analysis of the FDA adverse event report system database". Nutrition, Metabolism and Cardiovascular Diseases. 27 (12): 1108–1113. doi:10.1016/j.numecd.2017.10.011. ISSN 0939-4753. PMID 29174031.
  21. ^ Neuen, Brendon L.; Young, Tamara; Heerspink, Hiddo J. L.; Neal, Bruce; Perkovic, Vlado; Billot, Laurent; Mahaffey, Kenneth W.; Charytan, David M.; Wheeler, David C.; Arnott, Clare; Bompoint, Severine; Levin, Adeera; Jardine, Meg J. (November 2019). "SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis". The Lancet. Diabetes & Endocrinology. 7 (11): 845–854. doi:10.1016/S2213-8587(19)30256-6. hdl:10044/1/79694. ISSN 2213-8595. PMID 31495651. S2CID 202003028.
  22. ^ BNF 73. Tavistock Square, London: BMJ Group. March–September 2017.
  23. ^ Scheen, André J. (2014). "Drug–Drug Interactions with Sodium-Glucose Cotransporters Type 2 (SGLT2) Inhibitors, New Oral Glucose-Lowering Agents for the Management of Type 2 Diabetes Mellitus". Clinical Pharmacokinetics (Submitted manuscript). 53 (4): 295–304. doi:10.1007/s40262-013-0128-8. hdl:2268/164207. PMID 24420910. S2CID 5228432.
  24. ^ a b c Bhartia, Mithun; Tahrani, Abd A.; Barnett, Anthony H. (2011). "SGLT-2 Inhibitors in Development for Type 2 Diabetes Treatment". The Review of Diabetic Studies. 8 (3): 348–354. doi:10.1900/RDS.2011.8.348. PMC 3280669. PMID 22262072.
  25. ^ a b c Yang, Li; Li, Haiyan; Li, Hongmei; Bui, Anh; Chang, Ming; Liu, Xiaoni; Kasichayanula, Sreeneeranj; Griffen, Steven C.; Lacreta, Frank P.; Boulton, David W. (2013). "Pharmacokinetic and Pharmacodynamic Properties of Single- and Multiple-Dose of Dapagliflozin, a Selective Inhibitor of SGLT2, in Healthy Chinese Subjects". Clinical Therapeutics. 35 (8): 1211–1222.e2. doi:10.1016/J.Clinthera.2013.06.017. PMID 23910664.
  26. ^ "Drug Approval Package: Invokana (canagliflozin) Tablets NDA #204042". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 5 May 2020.
  27. ^ "Invokana EPAR". European Medicines Agency (EMA). Retrieved 1 October 2018.
  28. ^ "Forxiga EPAR". European Medicines Agency (EMA). Retrieved 17 February 2020.
  29. ^ "Drug Approval Package: Farxiga (dapagliflozin) Tablets NDA #202293". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 5 May 2020.
  30. ^ "FDA approves Jardiance (empagliflozin) tablets for adults with type 2 diabetes". Boehringer Ingelheim / Eli Lilly and Company. 1 August 2014. Archived from the original on 5 November 2014. Retrieved 5 November 2014.
  31. ^ "FDA Advisory Committee recommends approval of Jardiance (empagliflozin) for cardiovascular indication in 12-11 vote". Yahoo! Finance. 28 June 2016. Retrieved 10 August 2016.
  32. ^ "Steglatro (ertugliflozin), Steglujan (ertugliflozin and sitagliptin), Segluromet (ertugliflozin and metformin hydrochloride) Tablets". U.S. Food and Drug Administration (FDA). 5 March 2018. Retrieved 6 May 2020.
  33. ^ "Approval of Suglat® Tablets, a Selective SGLT2 Inhibitor for Treatment of Type 2 Diabetes, in Japan". January 17, 2014.
  34. ^ Poole, Raewyn M.; Dungo, Rosselle T. (26 March 2014). "Ipragliflozin: First Global Approval". Drugs. 74 (5): 611–617. doi:10.1007/s40265-014-0204-x. PMID 24668021. S2CID 19837125.
  35. ^ Markham, Anthony; Elkinson, Shelley (2014). "Luseogliflozin: First Global Approval". Drugs. 74 (8): 945–950. doi:10.1007/s40265-014-0230-8. PMID 24848756. S2CID 1770988.
  36. ^ Da Silva, Paula Nogueira; Da Conceição, Raissa Alves; Do Couto Maia, Rodolfo; De Castro Barbosa, Maria Leticia (2018). "Sodium–glucose cotransporter 2 (SGLT-2) inhibitors: A new antidiabetic drug class". MedChemComm. 9 (8): 1273–1281. doi:10.1039/c8md00183a. PMC 6096352. PMID 30151080.
  37. ^ Clinical trial number NCT02531035 for "A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone (inTandem3)" at
  38. ^ "Sotagliflozin as an Adjunct to Insulin for Type 1 Diabetes - FDA" (PDF). Food and Drug Administration.
  39. ^ Sanofi (17 January 2019). "Sanofi: FDA advisory committee votes on Zynquista(TM) (sotagliflozin) as treatment for adults with type 1 diabetes". GlobeNewswire News Room.
  40. ^ Poole, Raewyn M.; Prossler, Jennifer E. (2014). "Tofogliflozin: First Global Approval". Drugs. 74 (8): 939–944. doi:10.1007/s40265-014-0229-1. PMID 24848755. S2CID 37021884.
  41. ^ Chao, E. C. (2014). "SGLT-2 Inhibitors: A New Mechanism for Glycemic Control". Clinical Diabetes. 32 (1): 4–11. doi:10.2337/diaclin.32.1.4. PMC 4521423. PMID 26246672.
  42. ^ a b c Anderson, Sarah L.; Marrs, Joel C. (2012). "Dapagliflozin for the Treatment of Type 2 Diabetes". Annals of Pharmacotherapy. 46 (4): 590–598. doi:10.1345/aph.1Q538. PMID 22433611. S2CID 207264502.
  43. ^ a b c Li, An-Rong; Zhang, Jian; Greenberg, Joanne; Lee, Taeweon; Liu, Jiwen (2011). "Discovery of non-glucoside SGLT2 inhibitors". Bioorganic & Medicinal Chemistry Letters. 21 (8): 2472–2475. doi:10.1016/j.bmcl.2011.02.056. PMID 21398124.
  44. ^ Hummel, Charles S.; Lu, Chuan; Liu, Jie; Ghezzi, Chiari; Hirayama, Bruce A.; Loo, Donald D. F.; Kepe, Vladimir; Barrio, Jorge R.; Wright, Ernest M. (2012). "Structural selectivity of human SGLT inhibitors". American Journal of Physiology. Cell Physiology. 302 (2): C373–C382. doi:10.1152/ajpcell.00328.2011. PMC 3328840. PMID 21940664.
  45. ^ a b c Plosker, Greg L. (2012). "Dapagliflozin". Drugs. 72 (17): 2289–2312. doi:10.2165/11209910-000000000-00000. PMID 23170914.
  46. ^ "Jardiance". Retrieved 31 October 2014.
  47. ^ "Farxiga". Retrieved 31 October 2014.
  48. ^ "Invokana". Retrieved 31 October 2014.
  49. ^ Madaan, Tushar; Akhtar, Mohd.; Najmi, Abul Kalam (2016). "Sodium glucose Co Transporter 2 (SGLT2) inhibitors: Current status and future perspective". European Journal of Pharmaceutical Sciences. 93: 244–252. doi:10.1016/j.ejps.2016.08.025. PMID 27531551.
  50. ^ a b Packer M (2020). "Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors: Potential Role in Mediating the Heart Failure Benefits of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors". Circulation: Heart Failure. 13 (9): e007197. doi:10.1161/CIRCHEARTFAILURE.120.007197. PMID 32894987. S2CID 221540765.
  51. ^ LARSON, GERALD L. (March–April 2015). "The synthesis of gliflozins". Chimica Oggi - Chemistry Today. 33 (2): 37–40.
  52. ^ David-Silva A, Esteves JV, Morais MR, Freitas HS, Zorn TM, Correa-Giannella ML, Machado UF (2020). "Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice". Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13: 739–751. doi:10.2147/DMSO.S242282. PMC 7085338. PMID 32231437.
  53. ^ Chen, Zeng-Hao; Wang, Ruo-Wen; Qing, Feng-Ling (2012). "Synthesis and biological evaluation of SGLT2 inhibitors: Gem-difluoromethylenated Dapagliflozin analogs". Tetrahedron Letters. 53 (17): 2171–2176. doi:10.1016/j.tetlet.2012.02.062.
  54. ^ Ng, Wai-Lung; Li, Ho-Chuen; Lau, Kit-Man; Chan, Anthony K. N.; Lau, Clara Bik-San; Shing, Tony K. M. (17 July 2017). "Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition". Scientific Reports. 7 (1): 5581. Bibcode:2017NatSR...7.5581N. doi:10.1038/s41598-017-05895-9. ISSN 2045-2322. PMC 5514135. PMID 28717146.
  55. ^ Ng, Wai-Lung; Li, Ho-Chuen; Lau, Kit-Man; Chan, Anthony K. N.; Lau, Clara Bik-San; Shing, Tony K. M. (2017). "Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition". Scientific Reports. 7 (1): 5581. Bibcode:2017NatSR...7.5581N. doi:10.1038/s41598-017-05895-9. PMC 5514135. PMID 28717146.
  56. ^ "7.5: Electron Affinities". Chemistry LibreTexts. 18 November 2014. Retrieved 30 September 2018.
  57. ^ Song, Kwang-Seop; Lee, Suk Ho; Kim, Min Ju; Seo, Hee Jeong; Lee, Junwon; Lee, Sung-Han; Jung, Myung Eun; Son, Eun-Jung; Lee, Minwoo; Kim, Jeongmin; Lee, Jinhwa (2010). "Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors". ACS Medicinal Chemistry Letters. 2 (2): 182–187. doi:10.1021/ml100256c. PMC 4018110. PMID 24900297.
  58. ^ Puchalska P, Crawford PA (2017). "Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics". Cell Metabolism. 25 (2): 262–284. doi:10.1016/j.cmet.2016.12.022. PMC 5313038. PMID 28178565.
  59. ^ Kolb H, Kempf K, Martin S (2021). "Ketone bodies: from enemy to friend and guardian angel". BMC Medicine. 19 (1): 313. doi:10.1186/s12916-021-02185-0. PMC 8656040. PMID 34879839.
  60. ^ Varzideh F, Kansakar U, Santulli G (July 2021). "SGLT2 inhibitors in cardiovascular medicine". Eur Heart J Cardiovasc Pharmacother. 7 (4): e67–e68. doi:10.1093/ehjcvp/pvab039. PMC 8488965. PMID 33964138.

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