Laminin subunit alpha-1

LAMA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JD4
Identifiers
Aliases	LAMA1, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
External IDs	OMIM: 150320 MGI: 99892 HomoloGene: 21146 GeneCards: LAMA1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	7,117,797 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	68,129,642 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; rectum; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; kidney; ; caudate nucleus; ; jejunal mucosa; ; putamen;
	Top expressed in
	Bowman's capsule; ; ovary; ; cumulus cell; ; inner renal medulla; ; yolk sac; ; cortical collecting duct; ; primitive streak; ; somite; ; molar; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; extracellular matrix structural constituent; protein binding; protein C-terminus binding; glycosphingolipid binding;
Cellular component	extracellular matrix; extracellular region; basement membrane; laminin-1 complex; laminin-3 complex; extracellular space; membrane; cell-cell junction; laminin complex; collagen-containing extracellular matrix;
Biological process	cell surface receptor signaling pathway; regulation of cell adhesion; cell adhesion; extracellular matrix organization; regulation of cell migration; regulation of embryonic development; morphogenesis of an epithelial sheet; protein phosphorylation; tissue development; neuron projection development; establishment of epithelial cell apical/basal polarity; retina development in camera-type eye; epithelial tube branching involved in lung morphogenesis; branching involved in salivary gland morphogenesis; retinal blood vessel morphogenesis; axon guidance; animal organ morphogenesis; camera-type eye development; blood vessel morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	284217
	16772
	ENSG00000101680
	ENSMUSG00000032796
	P25391
	P19137
	NM_005559
	NM_008480
	NP_005550
	NP_032506
	Wikidata
View/Edit Human	View/Edit Mouse

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.^[5]^[6]

Template:PBB Summary

Interactions

Laminin, alpha 1 has been shown to interact with FBLN2.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101680 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032796 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J (January 1990). "Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3". Genomics. 5 (4): 932–5. doi:10.1016/0888-7543(89)90136-5. PMID 2591971.
^ "Entrez Gene: LAMA1 laminin, alpha 1".
^ Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. 272 (5). UNITED STATES: 2814–20. doi:10.1074/jbc.272.5.2814. ISSN 0021-9258. PMID 9006922. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. 275 (45). UNITED STATES: 35192–9. doi:10.1074/jbc.M003261200. ISSN 0021-9258. PMID 10934193. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading