Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
| Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.114 | ||||||||
| CAS no. | 82047-77-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114, mannosidase II, exo-1,3-1,6-alpha-mannosidase, alpha-D-mannosidase II, alpha-mannosidase II, alpha1-3,6-mannosidase, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, Golgi alpha-mannosidase II, ManII, 1,3(1,6)-alpha-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3
This enzyme is involved in the synthesis of glycoproteins.
References
- ^ Harpaz N, Schachter H (May 1980). "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry. 255 (10): 4894–902. PMID 6445359.
- ^ Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.
- ^ Tulsiani DR, Opheim DJ, Touster O (May 1977). "Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes". The Journal of Biological Chemistry. 252 (10): 3227–33. PMID 863880.
- ^ Athanasopoulos VI, Niranjan K, Rastall RA (Mar 2005). "The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research. 340 (4): 609–17. doi:10.1016/j.carres.2005.01.005. PMID 15721331.
External links
- Mannosyl-oligosaccharide+1,3-1,6-alpha-mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)