Pyranose oxidase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
pyranose oxidase
1tt0.jpg
Pyranose oxidase tetramer, Trametes ochracea
Identifiers
EC number1.1.3.10
CAS number37250-80-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a pyranose oxidase (EC 1.1.3.10) is an enzyme that catalyzes the chemical reaction

D-glucose + O2 2-dehydro-D-glucose + H2O2

Thus, the two substrates of this enzyme are D-glucose and O2, whereas its two products are 2-dehydro-D-glucose and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyranose:oxygen 2-oxidoreductase. Other names in common use include glucose 2-oxidase, and pyranose-2-oxidase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1TT0, 1TZL, 2F5V, 2F6C, 2IGK, 2IGM, 2IGN, and 2IGO.

References[edit]

  • Janssen FW, Ruelius HW (1968). "Carbohydrate oxidase, a novel enzyme from Polyporus obtusus. II Specificity and characterization of reaction products". Biochim. Biophys. Acta. 167 (3): 501&ndash, 10. doi:10.1016/0005-2744(68)90040-5. PMID 5722278.
  • Machida Y, Nakanishi T (1984). "Purification and properties of pyranose oxidase from Coriolus versicolor". Agric. Biol. Chem. 48: 2463&ndash, 2470. doi:10.1271/bbb1961.48.2463.
  • Neidleman SL, Amon WF Jr & Geigert J (1981). "Process for the production of fructose". Chem. Abstr. 94: 20737.
  • Ruelius HW, Kerwin RM, Janssen FW (1968). "Carbohydrate oxidase, a novel enzyme from Polyporus obtusus. I Isolation and purification". Biochim. Biophys. Acta. 167 (3): 493&ndash, 500. doi:10.1016/0005-2744(68)90039-9. PMID 5725162.