Pyranose oxidase

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pyranose oxidase
Pyranose oxidase tetramer, Trametes ochracea
EC number1.1.3.10
CAS number37250-80-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a pyranose oxidase (EC is an enzyme that catalyzes the chemical reaction

D-glucose + O2 2-dehydro-D-glucose + H2O2

Thus, the two substrates of this enzyme are D-glucose and O2, whereas its two products are 2-dehydro-D-glucose and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyranose:oxygen 2-oxidoreductase. Other names in common use include glucose 2-oxidase, and pyranose-2-oxidase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1TT0, 1TZL, 2F5V, 2F6C, 2IGK, 2IGM, 2IGN, and 2IGO.


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  • Neidleman SL, Amon WF Jr, Geigert J (1981). "Process for the production of fructose". Chem. Abstr. 94: 20737.
  • Ruelius HW, Kerwin RM, Janssen FW (1968). "Carbohydrate oxidase, a novel enzyme from Polyporus obtusus. I Isolation and purification". Biochim. Biophys. Acta. 167 (3): 493–500. doi:10.1016/0005-2744(68)90039-9. PMID 5725162.