SAG (gene)

SAG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZWJ
Identifiers
Aliases	SAG, RP47, S-AG, S-antigen; retina and pineal gland (arrestin), S-antigen visual arrestin
External IDs	OMIM: 181031; MGI: 98227; HomoloGene: 455; GeneCards: SAG; OMA:SAG - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,347,055 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,772,880 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; testicle; ; left testis; ; right testis; ; caudate nucleus; ; putamen; ; monocyte; ; granulocyte; ; bone marrow; ; mucosa of transverse colon;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; corneal stroma; ; pineal gland; ; epithelium of lens; ; iris; ; conjunctival fornix; ; embryo; ; ciliary body; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity; phosphoprotein binding; opsin binding; G protein-coupled receptor binding;
Cellular component	cytosol; photoreceptor inner segment; photoreceptor outer segment; membrane; cell projection;
Biological process	rhodopsin mediated signaling pathway; regulation of rhodopsin mediated signaling pathway; signal transduction; cell surface receptor signaling pathway; negative regulation of phosphoprotein phosphatase activity; G protein-coupled receptor internalization;
	Sources:Amigo / QuickGO
Orthologs
	6295
	20215
	ENSG00000281857; ENSG00000130561
	ENSMUSG00000056055
	P10523
	P20443
	NM_000541
	NM_009118
	NP_000532
	NP_033144
	Wikidata
View/Edit Human	View/Edit Mouse

S-arrestin is a protein that in humans is encoded by the SAG gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000130561 GRCh38: Ensembl release 89: ENSG00000281857, ENSG00000130561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056055 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamaki K, Tsuda M, Kikuchi T, Chen KH, Huang KP, Shinohara T (Jan 1991). "Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal gland". J Biol Chem. 265 (34): 20757–62. PMID 2249983.
^ "Entrez Gene: SAG S-antigen; retina and pineal gland (arrestin)".

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

References

Further reading