The Senedo were a native American Indian tribe who inhabited an area along the north fork of the Shenandoah River in what is present-day northern Virginia. Early colonial records noted encounters with a few men who said they were survivors of a massacre of the Senedo, which took place by the Catawba, their traditional enemy, between 1650 and 1700. They may have been Iroquoian-speaking. The Catawba were a Siouan-speaking people.
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