This is an old revision of this page, as edited by CheMoBot(talk | contribs) at 03:46, 8 September 2016(Updating {{infobox_drug}} (changes to verified and watched fields - updated 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref') per Chem/infobox_drug validation (report errors or [[user ta...). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 03:46, 8 September 2016 by CheMoBot(talk | contribs)(Updating {{infobox_drug}} (changes to verified and watched fields - updated 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref') per Chem/infobox_drug validation (report errors or [[user ta...)
Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]
^Zhao, ZZ; Liang, ZT; Zhou, H; Jiang, ZH; Liu, ZQ; Wong, YF; Xu, HX; Liu, L (2005). "Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method". Biological & Pharmaceutical Bulletin. 28 (1): 105–9. doi:10.1248/bpb.28.105. PMID15635172.
^Yamasaki, H (1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta medica Okayama. 30 (1): 1–20. PMID61710.
^Liu, L; Riese, J; Resch, K; Kaever, V (1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung. 44 (11): 1223–6. PMID7848335.
(what is this?) (verify)