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→‎top: Removed study about the index case. We shouldn't be discussing studies that have yet to be peer-reviewed, especially in the lead.
→‎{{anchor|origin}}Reservoir and zoonotic origin: Replaced ref that didn't really discuss pangolins being reservoir host.
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[[File:Zoo Leipzig - Tou Feng.jpg|thumb|right|alt=Chinese pangolin|The [[pangolin]] coronavirus has up to 92% resemblance to SARS-CoV-2.<ref name="CurrentOrigin" />]]
[[File:Zoo Leipzig - Tou Feng.jpg|thumb|right|alt=Chinese pangolin|The [[pangolin]] coronavirus has up to 92% resemblance to SARS-CoV-2.<ref name="CurrentOrigin" />]]

A [[phylogenetics]] study published in 2020 indicates that [[pangolin]]s are a reservoir host of SARS-CoV-2-like coronaviruses.<ref name="BMJ-Best-Practice" /> However, there is no direct evidence to link pangolins as an intermediate host of SARS-CoV-2 at this moment.<ref name="Ortiz-Prado2020" /> While there is scientific consensus that bats are the ultimate source of coronaviruses, the pangolin CoV is sister to both RaTG13 as well as SARS-CoV-2. Based on whole-genome sequence similarity, a pangolin coronavirus candidate strain was found to be less similar than RaTG13, but more similar than other bat coronaviruses to SARS-CoV-2. Therefore, based on [[maximum parsimony]] and current sample data, a specific population of bats is more likely to have directly transmitted SARS-CoV-2 to humans than a pangolin, while an evolutionary ancestor to bats was the source of general coronaviruses.<ref name="CurrentOrigin" />
A study published in July 2020 suggested that [[pangolin]]s are an intermediate host of SARS-CoV-2-like coronaviruses.<ref name="ZhaoJ2020">{{cite journal |vauthors=Zhao J, Cui W, Tian BP |title=The Potential Intermediate Hosts for SARS-CoV-2 |journal=Frontiers in Microbiology |volume=11 |issue= |pages=580137 |date=2020 |pmid=33101254 |pmc=7554366 |doi=10.3389/fmicb.2020.580137 |url=}}</ref><ref name="XiaoK2020July">{{cite journal |vauthors=Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, Li N, Guo Y, Li X, Shen X, Zhang Z, Shu F, Huang W, Li Y, Zhang Z, Chen RA, Wu YJ, Peng SM, Huang M, Xie WJ, Cai QH, Hou FH, Chen W, Xiao L, Shen Y |title=Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins |journal=Nature |volume=583 |issue=7815 |pages=286–289 |date=July 2020 |pmid=32380510 |doi=10.1038/s41586-020-2313-x |url=}}</ref> However, there is no direct evidence to link pangolins as an intermediate host of SARS-CoV-2 at this moment.<ref name="Ortiz-Prado2020" /> While there is scientific consensus that bats are the ultimate source of coronaviruses, the pangolin CoV is sister to both RaTG13 as well as SARS-CoV-2. Based on whole-genome sequence similarity, a pangolin coronavirus candidate strain was found to be less similar than RaTG13, but more similar than other bat coronaviruses to SARS-CoV-2. Therefore, based on [[maximum parsimony]] and current sample data, a specific population of bats is more likely to have directly transmitted SARS-CoV-2 to humans than a pangolin, while an evolutionary ancestor to bats was the source of general coronaviruses.<ref name="CurrentOrigin" />


The majority of the viral RNA is related to a variation of bat coronaviruses.<ref name="Stawicki2020" /> The spike protein appears to be a notable exception, however, possibly acquired through a more recent [[genetic recombination|recombination]] event with a pangolin coronavirus.<ref name="Timmer 2020" /> SARS-CoV-2’s entire receptor binding motif appears to have been introduced through recombination from coronaviruses of pangolins.<ref name="Li2020" /> Such a recombination event may have been a critical step in the evolution of SARS-CoV-2’s capability to infect humans.<ref name="Li2020" /> Recombination events have been key steps in the viral evolutionary process that lead to the emergence of new human diseases.<ref name="Rheman2020" /> Structural analysis of the receptor-binding domain (RBD) and human [[angiotensin-converting enzyme 2]] (ACE2) complex<ref name="Yan et al 2020" /> revealed key mutations on the RBD, such as F486 and N501, which form contacts with ACE2.<ref name="Ho 2020" /> These residues are found in the pangolin coronavirus.<ref name="Ho 2020" />
The majority of the viral RNA is related to a variation of bat coronaviruses.<ref name="Stawicki2020" /> The spike protein appears to be a notable exception, however, possibly acquired through a more recent [[genetic recombination|recombination]] event with a pangolin coronavirus.<ref name="Timmer 2020" /> SARS-CoV-2’s entire receptor binding motif appears to have been introduced through recombination from coronaviruses of pangolins.<ref name="Li2020" /> Such a recombination event may have been a critical step in the evolution of SARS-CoV-2’s capability to infect humans.<ref name="Li2020" /> Recombination events have been key steps in the viral evolutionary process that lead to the emergence of new human diseases.<ref name="Rheman2020" /> Structural analysis of the receptor-binding domain (RBD) and human [[angiotensin-converting enzyme 2]] (ACE2) complex<ref name="Yan et al 2020" /> revealed key mutations on the RBD, such as F486 and N501, which form contacts with ACE2.<ref name="Ho 2020" /> These residues are found in the pangolin coronavirus.<ref name="Ho 2020" />

Revision as of 01:20, 31 December 2020

This article is about the virus that causes COVID-19. For the virus that causes SARS, see Severe acute respiratory syndrome coronavirus. For the species to which both viruses belong, see Severe acute respiratory syndrome–related coronavirus.

Template:Use Commonwealth English

Severe acute respiratory syndrome coronavirus 2
Electron micrograph of SARS-CoV-2 virions with visible coronae
Transmission electron micrograph of SARS-CoV-2 virions with visible coronae
Illustration of a SARS-CoV-2 virion
Illustration of a SARS-CoV-2 virion[1]
  Red protrusions: spike proteins (S)[1]
  Grey coating: the envelope, composed mainly of lipids, which can be destroyed with alcohol or soap[1]
  Yellow deposits: envelope proteins (E)[1]
  Orange deposits: membrane proteins (M)[1]
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Species:
Severe acute respiratory syndrome–related coronavirus
Strain:
Severe acute respiratory syndrome coronavirus 2
Variants
Synonyms
  • 2019-nCoV

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[2][3] is the virus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Colloquially known as simply the coronavirus, it was previously referred to by its provisional name, 2019 novel coronavirus (2019-nCoV),[4][5][6][7] and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19).[8][9][10][11] The World Health Organization declared the outbreak a Public Health Emergency of International Concern on 30 January 2020, and a pandemic on 11 March 2020.[12][13]

SARS-CoV-2 is a positive-sense single-stranded RNA virus[14][15] (and hence Baltimore class IV[16]) that is contagious in humans.[17] As described by the US National Institutes of Health, it is the successor to SARS-CoV-1,[10][18] the strain that caused the 2002–2004 SARS outbreak.

Taxonomically, SARS-CoV-2 is a strain of severe acute respiratory syndrome-related coronavirus (SARSr-CoV).[2] It is believed to have zoonotic origins and has close genetic similarity to bat coronaviruses, suggesting it emerged from a bat-borne virus.[19][20][21][9] There is no evidence yet to link an intermediate host, such as a pangolin, to its introduction to humans.[22][23] The virus shows little genetic diversity, indicating that the spillover event introducing SARS-CoV-2 to humans is likely to have occurred in late 2019.[24]

Epidemiological studies estimate each infection results in 5.7 new ones when no members of the community are immune and no preventive measures taken.[25] The virus primarily spreads between people through close contact and via respiratory droplets produced from coughs or sneezes.[26][27] It mainly enters human cells by binding to the angiotensin converting enzyme 2 (ACE2).[19][28][29][30]

Terminology

The name "2019-nCoV" in use in a trilingual sign at a Lisbon health facility in February 2020.
See also: Trump administration communication during the COVID-19 pandemic § Terminology

During the initial outbreak in Wuhan, China, various names were used for the virus; some names used by different sources included the "coronavirus" or "Wuhan coronavirus".[31][32] In January 2020, the World Health Organisation recommended "2019 novel coronavirus" (2019-nCov)[33][5] as the provisional name for the virus. This was in accordance with WHO's 2015 guidance[34] against using geographical locations, animal species, or groups of people in disease and virus names.[35][36]

On 11 February 2020, the International Committee on Taxonomy of Viruses adopted the official name "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2).[37] To avoid confusion with the disease SARS, the WHO sometimes refers to SARS-CoV-2 as "the COVID-19 virus" in public health communications[38][39] and the name HCoV-19 was included in some research articles.[8][9][10]

The general public often calls both the virus and the disease it causes, "coronavirus". U.S. President Donald Trump repeatedly referred to the virus as the "Chinese virus" in tweets, interviews, and White House press briefings, which drew some criticism that he was stigmatizing the disease with racial or nationalistic overtones.[40][41][42]

Virology

Infection and transmission

Main article: Transmission of COVID-19

Human-to-human transmission of SARS-CoV-2 was confirmed on 20 January 2020, during the COVID-19 pandemic.[17][43][44][45] Transmission was initially assumed to occur primarily via respiratory droplets from coughs and sneezes within a range of about 1.8 metres (6 ft).[27][46] Laser light scattering experiments suggest speaking as an additional mode of transmission.[47][48] Other studies have suggested that the virus may be airborne as well, with aerosols potentially being able to transmit the virus.[49][50][51] During human-to-human transmission, an average 1000 infectious SARS-CoV-2 virions are thought to initiate a new infection.[52][53]

Indirect contact via contaminated surfaces is another possible cause of infection.[54] Preliminary research indicates that the virus may remain viable on plastic (polypropylene) and stainless steel (AISI 304) for up to three days, but does not survive on cardboard for more than one day or on copper for more than four hours;[10] the virus is inactivated by soap, which destabilises its lipid bilayer.[55][56] Viral RNA has also been found in stool samples and semen from infected individuals.[57][58]

The degree to which the virus is infectious during the incubation period is uncertain, but research has indicated that the pharynx reaches peak viral load approximately four days after infection[59][60] or the first week of symptoms, and declines after.[61]

A study by a team of researchers from the University of North Carolina found that the nasal cavity is seemingly the dominant initial site for infection with subsequent aspiration-mediated virus seeding into the lungs in SARS-CoV-2 pathogenesis.[62] They found that there was an infection gradient from high in proximal towards low in distal pulmonary epithelial cultures, with a focal infection in ciliated cells and type 2 pneumocytes in the airway and alveolar regions respectively.[62]

There is some evidence of human-to-animal transmission of SARS-CoV-2, including examples in felids.[63][64] Some institutions have advised those infected with SARS-CoV-2 to restrict contact with animals.[65][66]

Asymptomatic transmission

On 1 February 2020, the World Health Organization (WHO) indicated that "transmission from asymptomatic cases is likely not a major driver of transmission".[67] One meta-analysis found that 17% of infections are asymptomatic, and asymptomatic individuals were 42% less likely to transmit the virus.[68]

However, an epidemiological model of the beginning of the outbreak in China suggested that "pre-symptomatic shedding may be typical among documented infections" and that subclinical infections may have been the source of a majority of infections.[69] That may explain how out of 217 onboard a cruise liner that docked at Montevideo, only 24 of 128 who tested positive for viral RNA showed symptoms.[70] Similarly, a study of ninety-four patients hospitalized in January and February 2020 estimated patients shed the greatest amount of virus two to three days before symptoms appear and that "a substantial proportion of transmission probably occurred before first symptoms in the index case".[71]

Reinfection

There are still a lot of questions about reinfection and long-term immunity.[72] It is not known how common reinfection is, but reports have indicated that it is occurring with variable severity.[72]

The first reported case of reinfection was a 33-year-old man from Hong Kong who first tested positive on 26 March 2020, was discharged on 15 April 2020 after two negative tests, and tested positive again on 15 August 2020 (142 days later), which was confirmed by whole-genome sequencing showing that the viral genomes between the episodes belong to different clades.[73] The findings had the implications that herd immunity may not eliminate the virus if reinfection is not an uncommon occurrence and that vaccines may not be able to provide lifelong protection against the virus.[73]

Another case study described a 25-year-old man from Nevada who tested positive for SARS-CoV-2 on 18 April 2020 and on 5 June 2020 (separated by two negative tests). Since genomic analyses showed significant genetic differences between the SARS-CoV-2 variant sampled on those two dates, the case study authors determined this was a reinfection.[74] The man's second infection was symptomatically more severe than the first infection, but the mechanisms that could account for this is not known.[74]

Reservoir and zoonotic origin

Transmission of SARS-CoV-1 and SARS-CoV-2 from mammals as biological carriers to humans

The first known infections from the SARS-CoV-2 strain were discovered in Wuhan, China.[19] The original source of viral transmission to humans remains unclear, as does whether the strain became pathogenic before or after the spillover event.[24][75][9] Because many of the early infectees were workers at the Huanan Seafood Market,[76][77] it has been suggested that the strain might have originated from the market.[9][78] However, other research indicates that visitors may have introduced the virus to the market, which then facilitated rapid expansion of the infections.[24][79] A phylogenetic network analysis of 160 early coronavirus genomes sampled from December 2019 to February 2020 showed that the virus type most closely related to the bat coronavirus was most abundant in Guangdong, China, and designated type "A". The predominant type among samples from Wuhan, "B", is more distantly related to the bat coronavirus than the ancestral type "A".[80][81]

Research into the natural reservoir of the virus strain that caused the 2002–2004 SARS outbreak has resulted in the discovery of many SARS-like bat coronaviruses, most originating in the Rhinolophus genus of horseshoe bats. Phylogenetic analysis indicates that samples taken from Rhinolophus sinicus show a resemblance of 80% to SARS-CoV-2.[21][82][83] Phylogenetic analysis also indicates that a virus from Rhinolophus affinis, collected in Yunnan province and designated RaTG13, has a 96% resemblance to SARS-CoV-2.[19][84]

Samples taken from Rhinolophus sinicus, a species of horseshoe bats, show an 80% resemblance to SARS-CoV-2.

Bats are considered the most likely natural reservoir of SARS-CoV-2,[85][86] but differences between the bat coronavirus and SARS-CoV-2 suggest that humans were infected via an intermediate host.[78] Although studies have suggested some likely candidates, the number and identities of intermediate hosts remain uncertain.[87] Nearly half of the strain's genome has a phylogenetic lineage distinct from known relatives.[88]

Chinese pangolin
The pangolin coronavirus has up to 92% resemblance to SARS-CoV-2.[89]

A study published in July 2020 suggested that pangolins are an intermediate host of SARS-CoV-2-like coronaviruses.[90][91] However, there is no direct evidence to link pangolins as an intermediate host of SARS-CoV-2 at this moment.[92] While there is scientific consensus that bats are the ultimate source of coronaviruses, the pangolin CoV is sister to both RaTG13 as well as SARS-CoV-2. Based on whole-genome sequence similarity, a pangolin coronavirus candidate strain was found to be less similar than RaTG13, but more similar than other bat coronaviruses to SARS-CoV-2. Therefore, based on maximum parsimony and current sample data, a specific population of bats is more likely to have directly transmitted SARS-CoV-2 to humans than a pangolin, while an evolutionary ancestor to bats was the source of general coronaviruses.[89]

The majority of the viral RNA is related to a variation of bat coronaviruses.[93] The spike protein appears to be a notable exception, however, possibly acquired through a more recent recombination event with a pangolin coronavirus.[94] SARS-CoV-2’s entire receptor binding motif appears to have been introduced through recombination from coronaviruses of pangolins.[95] Such a recombination event may have been a critical step in the evolution of SARS-CoV-2’s capability to infect humans.[95] Recombination events have been key steps in the viral evolutionary process that lead to the emergence of new human diseases.[96] Structural analysis of the receptor-binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2) complex[97] revealed key mutations on the RBD, such as F486 and N501, which form contacts with ACE2.[98] These residues are found in the pangolin coronavirus.[98]

Pangolins are protected under Chinese law, but their poaching and trading for use in traditional Chinese medicine remains common in the black market.[99][100] Deforestation, wildlife farming and trade in unsanitary conditions increases the risk of new zoonotic diseases.[101][102][103][104]

All available evidence suggests that SARS-CoV-2 has a natural animal origin and is not genetically engineered.[105] Nevertheless, laboratory origin of SARS-CoV-2 cannot be ruled out.[106] According to computational simulations on protein folding, the RBD of the spike protein of SARS-CoV-2 should have an unremarkable binding affinity. In actuality, however, it has very efficient binding to the human ACE2 receptor. To expose the RBD for fusion, furin proteases must first cleave the S protein. Furin proteases are abundant in the respiratory tract and lung epithelial cells. Additionally, the backbone[clarification needed] of the virus does not resemble any previously described in scientific literature used for genetic modification. The possibility that the virus could have gained the necessary adaptations through cell culture in a laboratory setting is challenged by scientists who assert that "the generation of the predicted O-linked glycans... suggest[s] the involvement of an immune system."[107][9]

Phylogenetics and taxonomy

Genomic information
Genomic organisation of isolate Wuhan-Hu-1, the earliest sequenced sample of SARS-CoV-2
NCBI genome ID86693
Genome size29,903 bases
Year of completion2020
Genome browser (UCSC)

SARS-CoV-2 belongs to the broad family of viruses known as coronaviruses.[32] It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Other coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ~34%). It is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV.[108]

Like the SARS-related coronavirus strain implicated in the 2003 SARS outbreak, SARS-CoV-2 is a member of the subgenus Sarbecovirus (beta-CoV lineage B).[109][110] Its RNA sequence is approximately 30,000 bases in length,[14] relatively long for a coronavirus. The rate of mutation is proportional to length, but the virus has mechanisms which reduce the mutation rate.[111] SARS-CoV-2 is unique among known betacoronaviruses in its incorporation of a polybasic cleavage site, a characteristic known to increase pathogenicity and transmissibility in other viruses.[9][112][113]

With a sufficient number of sequenced genomes, it is possible to reconstruct a phylogenetic tree of the mutation history of a family of viruses. By 12 January 2020, five genomes of SARS-CoV-2 had been isolated from Wuhan and reported by the Chinese Center for Disease Control and Prevention (CCDC) and other institutions;[14][114] the number of genomes increased to 42 by 30 January 2020.[115] A phylogenetic analysis of those samples showed they were "highly related with at most seven mutations relative to a common ancestor", implying that the first human infection occurred in November or December 2019.[115] As of 7 May 2020, 4,690 SARS-CoV-2 genomes sampled on six continents were publicly available.[116][clarification needed]

On 11 February 2020, the International Committee on Taxonomy of Viruses announced that according to existing rules that compute hierarchical relationships among coronaviruses based on five conserved sequences of nucleic acids, the differences between what was then called 2019-nCoV and the virus strain from the 2003 SARS outbreak were insufficient to make them separate viral species. Therefore, they identified 2019-nCoV as a strain of Severe acute respiratory syndrome-related coronavirus.[2]

In July 2020, scientists reported that a more infectious SARS-CoV-2 variant with spike protein variant G614 has replaced D614 as the dominant form in the pandemic.[117][118] In October 2020 scientists reported in a preprint that a variant, 20A.EU1, was first observed in Spain in early summer and has become the most frequent variant in multiple European countries. They also illustrate the emergence and spread of other frequent clusters of sequences using Nextstrain.[119][120]

In October 2020, researchers discovered a possible overlapping gene named ORF3d, in the Covid-19 virus genome. It is unknown if the protein produced by ORF3d has any function, but it provokes a strong immune response. ORF3d has been identified before, in a variant of coronavirus that infects pangolins.[121][122]

Strains and variants

Main article: Variants of severe acute respiratory syndrome coronavirus 2

There are many thousands of variants of SARS-CoV-2, which are grouped into clades.[123] Several different clade nomenclatures have been proposed. Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divdes them into seven (L, O, V, S, G, GH, and GR).[124]

Several notable variants of SARS-CoV-2 emerged in the fall of 2020.

  • The Variant of Concern 202012/01 (VOC 202012/01) is believed to have emerged in the United Kingdom in September. Preliminary epidemiological markers suggest that the variant is more highly transmissible, but there is no evidence that it affects disease severity or vaccine efficacy. Among the variant's several mutations is one in the receptor-binding domain of the spike protein that changes the asparagine at position 501 to tyrosine (N501Y). This mutation may cause the virus to bind more tightly to the ACE2 receptor.[125][126]
  • The 501Y.V2 Variant, which has the same N501Y mutation, arose independently in South Africa. It was detected in patient specimens collected at the beginning of October 2020. There is no evidence that the mutations increase transmissibility of the variant.[125][126]
  • The B.1.207 variant appeared in Nigeria. It has a mutation in the spike protein (P681H) that is also found in the VOC 202012/01 variant. P681H is located near the S1/S2 furin cleavage site. There is no evidence that the mutations increase transmissibility of the variant.[125]
  • The Cluster 5 variant emerged among minks and mink farmers in Denmark. It has a set of mutations that have not been observed in other variants, including four amino acid changes in the spike protein. The variant moderately resists neutralizing antibodies. After strict quarantines, a ban on mink farming, and a mink euthanasia campaign, it is believed to have been eradicated.[127]

There is no evidence that these variants increase disease severity.[125][126][127]

Structural biology

Figure of a spherical SARSr-CoV virion showing locations of structural proteins forming the viral envelope and the inner nucleocapsid
Structure of a SARSr-CoV virion

Each SARS-CoV-2 virion is 50–200 nanometres in diameter.[77] Like other coronaviruses, SARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.[128] The spike protein, which has been imaged at the atomic level using cryogenic electron microscopy,[129][130] is the protein responsible for allowing the virus to attach to and fuse with the membrane of a host cell;[128] specifically, its S1 subunit catalyzes attachment, the S2 subunit fusion.[131]

SARS-CoV-2 spike homotrimer focusing upon one protein subunit with an ACE2 binding domain highlighted
SARS-CoV-2 spike homotrimer with one protein subunit highlighted. The ACE2 binding domain is magenta.

Protein modeling experiments on the spike protein of the virus soon suggested that SARS-CoV-2 has sufficient affinity to the receptor angiotensin converting enzyme 2 (ACE2) on human cells to use them as a mechanism of cell entry.[132] By 22 January 2020, a group in China working with the full virus genome and a group in the United States using reverse genetics methods independently and experimentally demonstrated that ACE2 could act as the receptor for SARS-CoV-2.[19][133][28][134] Studies have shown that SARS-CoV-2 has a higher affinity to human ACE2 than the original SARS virus strain.[129][135] SARS-CoV-2 may also use basigin to assist in cell entry.[136]

Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2.[29] After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide in the S2 subunit, and the host receptor ACE2.[131] After fusion, an endosome forms around the virion, separating it from the rest of the host cell. The virion escapes when the pH of the endosome drops or when cathepsin, a host cysteine protease, cleaves it.[131] The virion then releases RNA into the cell and forces the cell to produce and disseminate copies of the virus, which infect more cells.[137]

SARS-CoV-2 produces at least three virulence factors that promote shedding of new virions from host cells and inhibit immune response.[128] Whether they include downregulation of ACE2, as seen in similar coronaviruses, remains under investigation (as of May 2020).[138]

SARS-CoV-2 emerging from a human cell
SARS-CoV-2 virions emerging from a human cell
Digitally colourised scanning electron micrographs of SARS-CoV-2 virions (yellow) emerging from human cells cultured in a laboratory

Interaction with immune system

In response to currently approved vaccines (as well as to infection) the human immune system produces antibodies that target several regions of the spike protein, so it is thought unlikely that a single mutation would make vaccines less effective.[139][clarification needed]

As more mutations occur, vaccines may need to be altered. SARS-CoV-2 does not mutate as quickly as influenza viruses, and the new vaccines that had proved effective by the end of 2020 are types that can be adjusted if necessary.[140] The "platforms" they are built on are versatile, so rapid development is possible, but it's not clear what regulatory hurdles would be to approval.

Epidemiology

Main article: COVID-19 pandemic
Micrograph of SARS-CoV-2 virus particles isolated from a patient
Transmission electron micrograph of SARS-CoV-2 virions (red) isolated from a patient during the COVID-19 pandemic

Based on the low variability exhibited among known SARS-CoV-2 genomic sequences, the strain is thought to have been detected by health authorities within weeks of its emergence among the human population in late 2019.[24][141] The earliest case of infection currently known is dated to 1 December 2019, although an earlier case could have occurred on 17 November 2019.[142] The virus subsequently spread to all provinces of China and to more than 150 other countries across the world.[143] Human-to-human transmission of the virus has been confirmed in all these regions.[144] On 30 January 2020, SARS-CoV-2 was designated a Public Health Emergency of International Concern by the WHO,[145][12] and on 11 March 2020 the WHO declared it a pandemic.[13][146]

The basic reproduction number () of the virus has been estimated to be around 5.7.[25] This means each infection from the virus is expected to result in 5.7 new infections when no members of the community are immune and no preventive measures are taken. The reproduction number may be higher in densely populated conditions such as those found on cruise ships.[147] Many forms of preventive efforts may be employed in specific circumstances to reduce the propagation of the virus.[148]

There have been about 96,000 confirmed cases of infection in mainland China.[143] While the proportion of infections that result in confirmed cases or progress to diagnosable disease remains unclear,[149] one mathematical model estimated that 75,815 people were infected on 25 January 2020 in Wuhan alone, at a time when the number of confirmed cases worldwide was only 2,015.[150] Before 24 February 2020, over 95% of all deaths from COVID-19 worldwide had occurred in Hubei province, where Wuhan is located.[151][152] As of 10 March 2023, the percentage had decreased to 0.047%.[143]

As of 10 March 2023, there have been 676,609,955 total confirmed cases of SARS-CoV-2 infection in the ongoing pandemic.[143] The total number of deaths attributed to the virus is 6,881,955.[143] Many recoveries from both confirmed and untested infections go unreported, since some countries do not collect this data, but at least people have recovered from confirmed infections.[143]

References

  1. ^ a b c d e Giaimo C (1 April 2020). "The Spiky Blob Seen Around the World". The New York Times. Archived from the original on 2 April 2020. Retrieved 6 April 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  2. ^ a b c Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, et al. (March 2020). "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2". Nature Microbiology. 5 (4): 536–544. doi:10.1038/s41564-020-0695-z. PMC 7095448. PMID 32123347. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  3. ^ "Coronavirus disease named Covid-19". BBC News Online. 11 February 2020. Archived from the original on 15 February 2020. Retrieved 15 February 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  4. ^ Surveillance case definitions for human infection with novel coronavirus (nCoV): interim guidance v1, January 2020 (Report). World Health Organization. January 2020. hdl:10665/330376. WHO/2019-nCoV/Surveillance/v2020.1. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  5. ^ a b "Healthcare Professionals: Frequently Asked Questions and Answers". United States Centers for Disease Control and Prevention (CDC). 11 February 2020. Archived from the original on 14 February 2020. Retrieved 15 February 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  6. ^ "About Novel Coronavirus (2019-nCoV)". United States Centers for Disease Control and Prevention (CDC). 11 February 2020. Archived from the original on 11 February 2020. Retrieved 25 February 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  7. ^ Harmon A (4 March 2020). "We Spoke to Six Americans with Coronavirus". The New York Times. Archived from the original on 13 March 2020. Retrieved 16 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  8. ^ a b Wong, G.; Bi, Y. H.; Wang, Q. H.; Chen, X. W.; Zhang, Z. G.; Yao, Y. G. (2020). "Zoonotic origins of human coronavirus 2019 (HCoV-19 / SARS-CoV-2): Why is this work important?". Zoological Research. 41 (3): 213–219. doi:10.24272/j.issn.2095-8137.2020.031. PMC 7231470. PMID 32314559.
  9. ^ a b c d e f g Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF (17 March 2020). "Correspondence: The proximal origin of SARS-CoV-2". Nature Medicine. 26 (4): 450–452. doi:10.1038/s41591-020-0820-9. PMC 7095063. PMID 32284615. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  10. ^ a b c d van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. (17 March 2020). "Correspondence: Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1". The New England Journal of Medicine. 382 (16): 1564–1567. doi:10.1056/NEJMc2004973. PMC 7121658. PMID 32182409. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  11. ^ "hCoV-19 Database". China National GeneBank. Archived from the original on 17 June 2020. Retrieved 2 June 2020.
  12. ^ a b "Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)". World Health Organization (WHO) (Press release). 30 January 2020. Archived from the original on 31 January 2020. Retrieved 30 January 2020. {{cite press release}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  13. ^ a b "WHO Director-General's opening remarks at the media briefing on COVID-19 – 11 March 2020". World Health Organization (WHO) (Press release). 11 March 2020. Archived from the original on 11 March 2020. Retrieved 12 March 2020. {{cite press release}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  14. ^ a b c "CoV2020". GISAID EpifluDB. Archived from the original on 12 January 2020. Retrieved 12 January 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  15. ^ "The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections]". pubmed.ncbi.nlm.nih.gov. September 2020. doi:10.1007/s11481-020-09944-5. Retrieved 22 December 2020.
  16. ^ Baltimore, D (1971). "Expression of animal virus genomes". Bacteriological Reviews. 35 (3): 235–241. doi:10.1128/MMBR.35.3.235-241.1971. PMC 378387. PMID 4329869.
  17. ^ a b Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. (February 2020). "A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster". The Lancet. 395 (10223): 514–523. doi:10.1016/S0140-6736(20)30154-9. PMC 7159286. PMID 31986261. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  18. ^ "New coronavirus stable for hours on surfaces". National Institutes of Health (NIH). NIH.gov. 17 March 2020. Archived from the original on 23 March 2020. Retrieved 4 May 2020.
  19. ^ a b c d e Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (February 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273. Bibcode:2020Natur.579..270Z. doi:10.1038/s41586-020-2012-7. PMC 7095418. PMID 32015507. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  20. ^ Perlman S (February 2020). "Another Decade, Another Coronavirus". The New England Journal of Medicine. 382 (8): 760–762. doi:10.1056/NEJMe2001126. PMC 7121143. PMID 31978944. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  21. ^ a b Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M (April 2020). "The 2019-new coronavirus epidemic: Evidence for virus evolution". Journal of Medical Virology. 92 (4): 455–459. doi:10.1002/jmv.25688. PMC 7166400. PMID 31994738. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  22. ^ Novel Coronavirus (2019-nCoV): situation report, 22 (Report). World Health Organization. 11 February 2020. hdl:10665/330991. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  23. ^ Shield C (7 February 2020). "Coronavirus: From bats to pangolins, how do viruses reach us?". Deutsche Welle. Archived from the original on 4 June 2020. Retrieved 13 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  24. ^ a b c d Cohen J (January 2020). "Wuhan seafood market may not be source of novel virus spreading globally". Science. doi:10.1126/science.abb0611. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  25. ^ a b Sanche, S.; Lin, Y. T.; Xu, C.; Romero-Severson, E.; Hengartner, E.; Ke, R. (July 2020). "High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2". Emerging Infectious Diseases. 26 (7): 1470–1477. doi:10.3201/eid2607.200282. PMC 7323562. PMID 32255761.
  26. ^ "Q&A on coronaviruses (COVID-19)". World Health Organization (WHO). 11 February 2020. Archived from the original on 20 January 2020. Retrieved 24 February 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  27. ^ a b "How COVID-19 Spreads". U.S. Centers for Disease Control and Prevention (CDC). 27 January 2020. Archived from the original on 28 January 2020. Retrieved 29 January 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  28. ^ a b Letko M, Marzi A, Munster V (February 2020). "Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses". Nature Microbiology. 5 (4): 562–569. doi:10.1038/s41564-020-0688-y. PMC 7095430. PMID 32094589. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  29. ^ a b Hoffman M, Kliene-Weber H, Krüger N, Herrler T, Erichsen S, Schiergens TS, et al. (16 April 2020). "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor". Cell. 181 (2): 271–280.e8. doi:10.1016/j.cell.2020.02.052. PMC 7102627. PMID 32142651. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  30. ^ Wu, Katherine J. (15 April 2020). "There are more viruses than stars in the universe. Why do only some infect us? – More than a quadrillion quadrillion individual viruses exist on Earth, but most are not poised to hop into humans. Can we find the ones that are?". National Geographic Society. Archived from the original on 23 April 2020. Retrieved 18 May 2020.
  31. ^ Huang P (22 January 2020). "How Does Wuhan Coronavirus Compare with MERS, SARS and the Common Cold?". NPR. Archived from the original on 2 February 2020. Retrieved 3 February 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  32. ^ a b Fox D (24 January 2020). "What you need to know about the Wuhan coronavirus". Nature. doi:10.1038/d41586-020-00209-y. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  33. ^ World Health Organization (30 January 2020). Novel Coronavirus (2019-nCoV): situation report, 10 (Report). World Health Organization. hdl:10665/330775. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  34. ^ "World Health Organization Best Practices for the Naming of New Human Infectious Diseases" (PDF). WHO. May 2015. Archived (PDF) from the original on 12 February 2020.
  35. ^ "Novel coronavirus named 'Covid-19': WHO". TODAYonline. Archived from the original on 21 March 2020. Retrieved 11 February 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  36. ^ "The coronavirus spreads racism against—and among—ethnic Chinese". The Economist. 17 February 2020. Archived from the original on 17 February 2020. Retrieved 17 February 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  37. ^ "Naming the coronavirus disease (COVID-2019) and the virus that causes it". World Health Organization. Archived from the original on 28 February 2020. Retrieved 14 December 2020. ICTV announced "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)" as the name of the new virus on 11 February 2020. This name was chosen because the virus is genetically related to the coronavirus responsible for the SARS outbreak of 2003. While related, the two viruses are different. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  38. ^ Hui M (18 March 2020). "Why won't the WHO call the coronavirus by its name, SARS-CoV-2?". Quartz. Archived from the original on 25 March 2020. Retrieved 26 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  39. ^ "Naming the coronavirus disease (COVID-2019) and the virus that causes it". World Health Organization. Archived from the original on 28 February 2020. Retrieved 14 December 2020. From a risk communications perspective, using the name SARS can have unintended consequences in terms of creating unnecessary fear for some populations. ... For that reason and others, WHO has begun referring to the virus as "the virus responsible for COVID-19" or "the COVID-19 virus" when communicating with the public. Neither of these designations are [sic] intended as replacements for the official name of the virus as agreed by the ICTV. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  40. ^ Gstalter, Morgan (19 March 2020). "WHO official warns against calling it 'Chinese virus', says 'there is no blame in this'". The Hill. Archived from the original on 18 April 2020. Retrieved 21 March 2020.
  41. ^ Shinkman, Paul (17 March 2020). "Trump Fires Back at Complaints He's Stigmatizing China Over Coronavirus". US News. Archived from the original on 29 March 2020. Retrieved 21 March 2020.
  42. ^ Will Steakin (20 June 2020). "Trump heads to Tulsa for return rally amid pandemic, despite mounting warnings from health experts". Archived from the original on 20 June 2020. Retrieved 20 June 2020.
  43. ^ Li, Jin-Yan; You, Zhi; Wang, Qiong; Zhou, Zhi-Jian; Qiu, Ye; Luo, Rui; et al. (March 2020). "The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future". Microbes and Infection. 22 (2): 80–85. doi:10.1016/j.micinf.2020.02.002. PMC 7079563. PMID 32087334. Archived from the original on 14 April 2020. Retrieved 19 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  44. ^ Kessler, Glenn (17 April 2020). "Trump's false claim that the WHO said the coronavirus was 'not communicable'". The Washington Post. Archived from the original on 17 April 2020. Retrieved 17 April 2020.
  45. ^ Kuo, Lily (21 January 2020). "China confirms human-to-human transmission of coronavirus". The Guardian. Archived from the original on 22 March 2020. Retrieved 18 April 2020.
  46. ^ Edwards E (25 January 2020). "How does coronavirus spread?". NBC News. Archived from the original on 28 January 2020. Retrieved 13 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  47. ^ Anfinrud P, Stadnytskyi V, Bax CE, Bax A (May 2020). "Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering". The New England Journal of Medicine. 382 (21): 2061–2063. doi:10.1056/NEJMc2007800. PMC 7179962. PMID 32294341.
  48. ^ Stadnytskyi V, Bax CE, Bax A, Anfinrud P (June 2020). "The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 11875–11877. doi:10.1073/pnas.2006874117. PMC 7275719. PMID 32404416.
  49. ^ Mandavilli, Apoorva]] (4 July 2020). "239 Experts With One Big Claim: The Coronavirus Is Airborne – The W.H.O. has resisted mounting evidence that viral particles floating indoors are infectious, some scientists say. The agency maintains the research is still inconclusive". The New York Times. Archived from the original on 17 November 2020. Retrieved 5 July 2020.{{cite news}}: CS1 maint: numeric names: authors list (link)
  50. ^ Zeynep Tufekci (30 July 2020). "We Need to Talk About Ventilation". The Atlantic. Archived from the original on 17 November 2020. Retrieved 8 September 2020.
  51. ^ Lewis, Dyani (July 2020). "Mounting evidence suggests coronavirus is airborne — but health advice has not caught up". Nature. 583 (7817): 510–513. Bibcode:2020Natur.583..510L. doi:10.1038/d41586-020-02058-1. PMID 32647382. S2CID 220470431. Archived from the original on 14 September 2020. Retrieved 9 October 2020.
  52. ^ Popa, Alexandra; et al. (23 November 2020). "Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2". Science Translational Medicine. doi:10.1126/scitranslmed.abe2555. Retrieved 1 December 2020.
  53. ^ Prentiss, Mara; et al. (23 October 2020). "Superspreading Events Without Superspreaders: Using High Attack Rate Events to Estimate Nº for Airborne Transmission of COVID-19". medRxiv. doi:10.1101/2020.10.21.20216895. Retrieved 1 December 2020.
  54. ^ "Getting your workplace ready for COVID-19" (PDF). World Health Organization. 27 February 2020. Archived (PDF) from the original on 2 March 2020. Retrieved 3 March 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  55. ^ Yong E (20 March 2020). "Why the Coronavirus Has Been So Successful". The Atlantic. Archived from the original on 20 March 2020. Retrieved 20 March 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  56. ^ Gibbens S (18 March 2020). "Why soap is preferable to bleach in the fight against coronavirus". National Geographic. Archived from the original on 2 April 2020. Retrieved 2 April 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  57. ^ Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. (March 2020). "First Case of 2019 Novel Coronavirus in the United States". The New England Journal of Medicine. 382 (10): 929–936. doi:10.1056/NEJMoa2001191. PMC 7092802. PMID 32004427. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  58. ^ Li, Diangeng; Jin, Meiling; Bao, Pengtao; Zhao, Weiguo; Zhang, Shixi (7 May 2020). "Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019". JAMA Network Open. 3 (5): e208292. doi:10.1001/jamanetworkopen.2020.8292. PMC 7206502. PMID 32379329. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  59. ^ Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al. (April 2020). "Virological assessment of hospitalized patients with COVID-2019". Nature. 581 (7809): 465–469. Bibcode:2020Natur.581..465W. doi:10.1038/s41586-020-2196-x. PMID 32235945.
  60. ^ Kupferschmidt K (February 2020). "Study claiming new coronavirus can be transmitted by people without symptoms was flawed". Science. doi:10.1126/science.abb1524. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  61. ^ To, Kelvin Kai-Wang; Tsang, Owen Tak-Yin; Leung, Wai-Shing; Tam, Anthony Raymond; Wu, Tak-Chiu; Lung, David Christopher; et al. (March 2020). "Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study". The Lancet Infectious Diseases. 20 (5): 565–574. doi:10.1016/S1473-3099(20)30196-1. PMC 7158907. PMID 32213337. Archived from the original on 17 April 2020. Retrieved 21 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  62. ^ a b Hou, Yixuan J.; Okuda, Kenichi; Edwards, Caitlin E.; Martinez, David R.; Asakura, Takanori; Dinnon, Kenneth H.; et al. (July 2020). "SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract". Cell. 182 (2): 429–446.e14. doi:10.1016/j.cell.2020.05.042. PMC 7250779. PMID 32526206. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  63. ^ "Questions and Answers on the COVID-19: OIE – World Organisation for Animal Health". www.oie.int. Archived from the original on 31 March 2020. Retrieved 16 April 2020.
  64. ^ Goldstein, Joseph (6 April 2020). "Bronx Zoo Tiger Is Sick with the Coronavirus". The New York Times. Archived from the original on 9 April 2020. Retrieved 10 April 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  65. ^ "USDA Statement on the Confirmation of COVID-19 in a Tiger in New York". United States Department of Agriculture. 5 April 2020. Archived from the original on 15 April 2020. Retrieved 16 April 2020.
  66. ^ "If You Have Animals—Coronavirus Disease 2019 (COVID-19)". Centers for Disease Control and Prevention (CDC). 13 April 2020. Archived from the original on 1 April 2020. Retrieved 16 April 2020.
  67. ^ World Health Organization (1 February 2020). Novel Coronavirus (2019-nCoV): situation report, 12 (Report). World Health Organization. hdl:10665/330777. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  68. ^ Nogrady, Bianca (18 November 2020). "What the data say about asymptomatic COVID infections". Nature. 587 (7835): 534–535. doi:10.1038/d41586-020-03141-3.
  69. ^ Li R, Pei S, Chen B, Song Y, Zhang T, Yang W, et al. (16 March 2020). "Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)". Science. 368 (6490): 489–493. Bibcode:2020Sci...368..489L. doi:10.1126/science.abb3221. PMC 7164387. PMID 32179701. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  70. ^ Daily Telegraph, Thursday 28 May 2020, page 2 column 1, which refers to the medical journal Thorax; Thorax May 2020 article COVID-19: in the footsteps of Ernest Shackleton Archived 30 May 2020 at the Wayback Machine
  71. ^ He, Xi; Lau, Eric H. Y.; Wu, Peng; Deng, Xilong; Wang, Jian; Hao, Xinxin; et al. (15 April 2020). "Temporal dynamics in viral shedding and transmissibility of COVID-19". Nature Medicine. 26 (5): 672–675. doi:10.1038/s41591-020-0869-5. PMID 32296168. Archived from the original on 19 April 2020. Retrieved 21 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  72. ^ a b Ledford, Heidi (4 September 2020). "Coronavirus reinfections: three questions scientists are asking". Nature. 585 (7824): 168–169. doi:10.1038/d41586-020-02506-y. PMID 32887957. S2CID 221501940. Archived from the original on 17 November 2020. Retrieved 9 October 2020.
  73. ^ a b To, Kelvin Kai-Wang; Hung, Ivan Fan-Ngai; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Tam, Anthony Raymond; et al. (25 August 2020). "Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing". Clinical Infectious Diseases: ciaa1275. doi:10.1093/cid/ciaa1275. PMC 7499500. PMID 32840608. S2CID 221308584.
  74. ^ a b Tillett, Richard L; Sevinsky, Joel R; Hartley, Paul D; Kerwin, Heather; Crawford, Natalie; Gorzalski, Andrew; et al. (October 2020). "Genomic evidence for reinfection with SARS-CoV-2: a case study". The Lancet Infectious Diseases: S1473309920307647. doi:10.1016/S1473-3099(20)30764-7. PMC 7550103. PMID 33058797.
  75. ^ Eschner K (28 January 2020). "We're still not sure where the Wuhan coronavirus really came from". Popular Science. Archived from the original on 30 January 2020. Retrieved 30 January 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  76. ^ Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. (15 February 2020). "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China". The Lancet. 395 (10223): 497–506. doi:10.1016/S0140-6736(20)30183-5. PMC 7159299. PMID 31986264. Archived from the original on 31 January 2020. Retrieved 26 March 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  77. ^ a b Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. (15 February 2020). "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study". The Lancet. 395 (10223): 507–513. doi:10.1016/S0140-6736(20)30211-7. PMC 7135076. PMID 32007143. Archived from the original on 31 January 2020. Retrieved 9 March 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  78. ^ a b Cyranoski D (26 February 2020). "Mystery deepens over animal source of coronavirus". Nature. 579 (7797): 18–19. Bibcode:2020Natur.579...18C. doi:10.1038/d41586-020-00548-w. PMID 32127703. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  79. ^ Yu WB, Tang GD, Zhang L, Corlett RT (21 February 2020). "Decoding evolution and transmissions of novel pneumonia coronavirus using the whole genomic data". ChinaXiv. doi:10.12074/202002.00033 (inactive 11 November 2020). Archived from the original on 23 February 2020. Retrieved 25 February 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: DOI inactive as of November 2020 (link)
  80. ^ Forster P, Forster L, Renfrew C, Forster M (8 April 2020). "Phylogenetic network analysis of SARS-CoV-2 genomes" (PDF). PNAS. 117 (17): 9241–9243. doi:10.1073/pnas.2004999117. PMC 7196762. PMID 32269081. Archived (PDF) from the original on 16 April 2020. Retrieved 17 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  81. ^ "COVID-19: genetic network analysis provides 'snapshot' of pandemic origins". Cambridge University. 9 April 2020. Archived from the original on 16 April 2020. Retrieved 17 April 2020.
  82. ^ "Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome". National Center for Biotechnology Information (NCBI). 15 February 2020. Archived from the original on 4 June 2020. Retrieved 15 February 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  83. ^ "Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome". National Center for Biotechnology Information (NCBI). 15 February 2020. Archived from the original on 4 June 2020. Retrieved 15 February 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  84. ^ "Bat coronavirus isolate RaTG13, complete genome". National Center for Biotechnology Information (NCBI). 10 February 2020. Archived from the original on 15 May 2020. Retrieved 5 March 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  85. ^ Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) (PDF) (Report). World Health Organization (WHO). 24 February 2020. Archived (PDF) from the original on 29 February 2020. Retrieved 5 March 2020. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  86. ^ Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. (February 2020). "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding". The Lancet. 395 (10224): 565–574. doi:10.1016/S0140-6736(20)30251-8. PMC 7159086. PMID 32007145. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  87. ^ Wu D, Wu T, Liu Q, Yang Z (12 March 2020). "The SARS-CoV-2 outbreak: what we know". International Journal of Infectious Diseases. 94: 44–48. doi:10.1016/j.ijid.2020.03.004. ISSN 1201-9712. PMC 7102543. PMID 32171952. Archived from the original on 9 April 2020. Retrieved 16 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  88. ^ Paraskevis D, Kostaki EG, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S (April 2020). "Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event". Infection, Genetics and Evolution. 79: 104212. doi:10.1016/j.meegid.2020.104212. PMC 7106301. PMID 32004758. Archived from the original on 17 November 2020. Retrieved 9 April 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  89. ^ a b Zhang T, Wu Q, Zhang Z (19 March 2020). "Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak". Current Biology. 30 (7): 1346–1351.e2. doi:10.1016/j.cub.2020.03.022. PMC 7156161. PMID 32197085.
  90. ^ Zhao J, Cui W, Tian BP (2020). "The Potential Intermediate Hosts for SARS-CoV-2". Frontiers in Microbiology. 11: 580137. doi:10.3389/fmicb.2020.580137. PMC 7554366. PMID 33101254.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  91. ^ Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, Li N, Guo Y, Li X, Shen X, Zhang Z, Shu F, Huang W, Li Y, Zhang Z, Chen RA, Wu YJ, Peng SM, Huang M, Xie WJ, Cai QH, Hou FH, Chen W, Xiao L, Shen Y (July 2020). "Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins". Nature. 583 (7815): 286–289. doi:10.1038/s41586-020-2313-x. PMID 32380510.
  92. ^ Ortiz-Prado, Esteban; Simbaña-Rivera, Katherine; Gómez- Barreno, Lenin; Rubio-Neira, Mario; Guaman, Linda P.; Kyriakidis, Nikolaos C; et al. (September 2020). "Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review". Diagnostic Microbiology and Infectious Disease. 98 (1): 115094. doi:10.1016/j.diagmicrobio.2020.115094. ISSN 0732-8893. PMC 7260568. PMID 32623267. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  93. ^ Stawicki, Stanislaw P; Jeanmonod, Rebecca; Miller, Andrew C; Paladino, Lorenzo; Gaieski, David F; Yaffee, Anna Q; et al. (22 May 2020). "The 2019–2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of Academic International Medicine-World Academic Council of Emergency Medicine Multidisciplinary COVID-19 Working Group Consensus Paper". Journal of Global Infectious Diseases. 12 (2): 47–93. doi:10.4103/jgid.jgid_86_20. ISSN 0974-777X. PMC 7384689. PMID 32773996. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
  94. ^ Timmer, John (1 June 2020). "SARS-CoV-2 looks like a hybrid of viruses from two different species". Ars Technica. Archived from the original on 5 June 2020. Retrieved 6 June 2020.
  95. ^ a b Li, Xiaojun; Giorgi, Elena E.; Marichannegowda, Manukumar Honnayakanahalli; Foley, Brian; Xiao, Chuan; Kong, Xiang-Peng; et al. (July 2020). "Emergence of SARS-CoV-2 through recombination and strong purifying selection". Science Advances. 6 (27): eabb9153. Bibcode:2020SciA....6B9153L. doi:10.1126/sciadv.abb9153. ISSN 2375-2548. PMC 7458444. PMID 32937441. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  96. ^ Rehman, Saif ur; Shafique, Laiba; Ihsan, Awais; Liu, Qingyou (23 March 2020). "Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2". Pathogens. 9 (3): 240. doi:10.3390/pathogens9030240. ISSN 2076-0817. PMC 7157669. PMID 32210130. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
  97. ^ Yan, Renhong; Zhang, Yuanyuan; Li, Yaning; Xia, Lu; Guo, Yingying; Zhou, Qiang (27 March 2020). "Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2". Science. 367 (6485): 1444–1448. Bibcode:2020Sci...367.1444Y. doi:10.1126/science.abb2762. ISSN 1095-9203. PMC 7164635. PMID 32132184.
  98. ^ a b Ho, Mitchell (30 April 2020). "Perspectives on the development of neutralizing antibodies against SARS-CoV-2". Antibody Therapeutics. 3 (2): 109–114. doi:10.1093/abt/tbaa009. PMC 7291920. PMID 32566896. S2CID 219476100. Archived from the original on 14 June 2020. Retrieved 14 June 2020.
  99. ^ Kelly G (1 January 2015). "Pangolins: 13 facts about the world's most hunted animal". The Telegraph. Archived from the original on 24 December 2019. Retrieved 9 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  100. ^ Gorman J (27 February 2020). "China's Ban on Wildlife Trade a Big Step, but Has Loopholes, Conservationists Say". The New York Times. Archived from the original on 13 March 2020. Retrieved 23 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  101. ^ Carrington, Damian (27 April 2020). "Halt destruction of nature or suffer even worse pandemics, say world's top scientists". The Guardian. ISSN 0261-3077. Archived from the original on 15 May 2020. Retrieved 31 May 2020.
  102. ^ Pontes, Nadia (29 April 2020). "How deforestation can lead to more infectious diseases". DW.COM. Archived from the original on 5 May 2020. Retrieved 31 May 2020.
  103. ^ Cheng, Vincent C. C.; Lau, Susanna K. P.; Woo, Patrick C. Y.; Yuen, Kwok Yung (October 2007). "Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection". Clinical Microbiology Reviews. 20 (4): 660–694. doi:10.1128/CMR.00023-07. ISSN 0893-8512. PMC 2176051. PMID 17934078.
  104. ^ "Escaping the 'Era of Pandemics': experts warn worse crises to come; offer options to reduce risk". EurekAlert!. 29 October 2020. Archived from the original on 17 November 2020. Retrieved 30 October 2020.
  105. ^ "Origin of SARS-CoV-2". www.who.int. Archived from the original on 17 November 2020. Retrieved 14 October 2020.
  106. ^ Segreto, Rossana; Deigin, Yuri. "The genetic structure of SARS-CoV-2 does not rule out a laboratory origin". BioEssays. n/a (n/a): 2000240. doi:10.1002/bies.202000240.
  107. ^ "The COVID-19 coronavirus epidemic has a natural origin, scientists say—Scripps Research's analysis of public genome sequence data from SARS‑CoV‑2 and related viruses found no evidence that the virus was made in a laboratory or otherwise engineered". EurekAlert!. Scripps Research Institute. 17 March 2020. Archived from the original on 3 April 2020. Retrieved 15 April 2020.
  108. ^ Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. (February 2020). "A Novel Coronavirus from Patients with Pneumonia in China, 2019". The New England Journal of Medicine. 382 (8): 727–733. doi:10.1056/NEJMoa2001017. PMC 7092803. PMID 31978945. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  109. ^ "Phylogeny of SARS-like betacoronaviruses". nextstrain. Archived from the original on 20 January 2020. Retrieved 18 January 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  110. ^ Wong AC, Li X, Lau SK, Woo PC (February 2019). "Global Epidemiology of Bat Coronaviruses". Viruses. 11 (2): 174. doi:10.3390/v11020174. PMC 6409556. PMID 30791586. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
  111. ^ Ogando, Natacha S.; Ferron, Francois; Decroly, Etienne; Canard, Bruno; Posthuma, Clara C.; Snijder, Eric J. (2019). "The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity". Frontiers in Microbiology. 10: 1813. doi:10.3389/fmicb.2019.01813. ISSN 1664-302X. PMC 6693484. PMID 31440227.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  112. ^ Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D (9 March 2020). "Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein". Cell. 181 (2): 281–292.e6. doi:10.1016/j.cell.2020.02.058. PMC 7102599. PMID 32155444. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  113. ^ Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E (February 2020). "The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade". Antiviral Research. 176: 104742. doi:10.1016/j.antiviral.2020.104742. PMC 7114094. PMID 32057769. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  114. ^ "Initial genome release of novel coronavirus". Virological. 11 January 2020. Archived from the original on 12 January 2020. Retrieved 12 January 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  115. ^ a b Bedford T, Neher R, Hadfield N, Hodcroft E, Ilcisin M, Müller N. "Genomic analysis of nCoV spread: Situation report 2020-01-30". nextstrain.org. Archived from the original on 15 March 2020. Retrieved 18 March 2020.
  116. ^ "Genomic epidemiology of novel coronavirus - Global subsampling". Nextstrain. Archived from the original on 20 April 2020. Retrieved 7 May 2020.
  117. ^ "New, more infectious strain of COVID-19 now dominates global cases of virus: study". medicalxpress.com. Archived from the original on 17 November 2020. Retrieved 16 August 2020.
  118. ^ Korber, Bette; Fischer, Will M.; Gnanakaran, Sandrasegaram; Yoon, Hyejin; Theiler, James; Abfalterer, Werner; et al. (2 July 2020). "Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus". Cell. 182 (4): 812–827.e19. doi:10.1016/j.cell.2020.06.043. ISSN 0092-8674. PMC 7332439. PMID 32697968. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  119. ^ Meredith, Sam (29 October 2020). "A new coronavirus variant is seen spreading across Europe, research says". CNBC. Retrieved 10 November 2020.
  120. ^ Hodcroft, Emma B.; Zuber, Moira; Nadeau, Sarah; Comas, Iñaki; Candelas, Fernando González; Consortium, SeqCOVID-SPAIN; Stadler, Tanja; Neher, Richard A. (28 October 2020). "Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020". medRxiv. pp. 2020.10.25.20219063. doi:10.1101/2020.10.25.20219063. Retrieved 10 November 2020.
  121. ^ Dockrill, Peter (11 November 2020). "Scientists Just Found a Mysteriously Hidden 'Gene Within a Gene' in SARS-CoV-2". ScienceAlert. Archived from the original on 17 November 2020. Retrieved 11 November 2020.
  122. ^ Nelson, Chase W; et al. (1 October 2020). "Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic". eLife. 9. doi:10.7554/eLife.59633. PMC 7655111. PMID 33001029. Archived from the original on 17 November 2020. Retrieved 11 November 2020.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  123. ^ Koyama, Takahiko Koyama; Platt, Daniela; Parida, Laxmi (June 2020). "Variant analysis of SARS-CoV-2 genomes". Bulletin of the World Health Organization. 98: 495–504. doi:10.2471/BLT.20.253591. We detected in total 65776 variants with 5775 distinct variants.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  124. ^ Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole Á, Pereyaslov D (August 2020). "Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020". Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 25 (32). doi:10.2807/1560-7917.ES.2020.25.32.2001410. PMC 7427299. PMID 32794443.
  125. ^ a b c d "Emerging SARS-CoV-2 Variants". Centers for Disease Control and Prevention. 30 December 2020. Retrieved 30 December 2020.
  126. ^ a b c "Implications of Emerging SARS-CoV-2 Variant VOC 202012/01 in the UK". Centers for Disease Control and Prevention. 29 December 2020. Retrieved 30 December 2020.
  127. ^ a b "SARS-CoV-2 mink-associated variant strain – Denmark". WHO. 3 December 2020. Retrieved 30 December 2020.
  128. ^ a b c Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, et al. (February 2020). "Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods". Acta Pharmaceutica Sinica B. 10 (5): 766–788. doi:10.1016/j.apsb.2020.02.008. PMC 7102550. PMID 32292689. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  129. ^ a b Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. (February 2020). "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation". Science. 367 (6483): 1260–1263. Bibcode:2020Sci...367.1260W. doi:10.1126/science.abb2507. PMC 7164637. PMID 32075877. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  130. ^ Mandelbaum RF (19 February 2020). "Scientists Create Atomic-Level Image of the New Coronavirus's Potential Achilles Heel". Gizmodo. Archived from the original on 8 March 2020. Retrieved 13 March 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  131. ^ a b c Aronson, Jeffrey K (25 March 2020). "Coronaviruses – a general introduction". Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford. Archived from the original on 22 May 2020. Retrieved 24 May 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  132. ^ Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. (March 2020). "Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission". Science China Life Sciences. 63 (3): 457–460. doi:10.1007/s11427-020-1637-5. PMC 7089049. PMID 32009228. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  133. ^ Letko M, Munster V (January 2020). "Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV" (PDF). bioRxiv (preprint). doi:10.1101/2020.01.22.915660. PMC 7217099. PMID 32511294. Archived (PDF) from the original on 22 April 2020. Retrieved 5 May 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  134. ^ El Sahly HM. "Genomic Characterization of the 2019 Novel Coronavirus". The New England Journal of Medicine. Archived from the original on 17 February 2020. Retrieved 9 February 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  135. ^ "Novel coronavirus structure reveals targets for vaccines and treatments". National Institutes of Health (NIH). 2 March 2020. Archived from the original on 1 April 2020. Retrieved 3 April 2020.
  136. ^ Wang K, Chen W, Zhou YS, Lian JQ, Zhang Z, Du P, et al. (14 March 2020). "SARS-CoV-2 invades host cells via a novel route: CD147-spike protein" (PDF). bioRxiv (preprint). doi:10.1101/2020.03.14.988345. S2CID 214725955. Archived (PDF) from the original on 11 May 2020. Retrieved 5 May 2020. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  137. ^ "Anatomy of a Killer: Understanding SARS-CoV-2 and the drugs that might lessen its power". The Economist. 12 March 2020. Archived from the original on 14 March 2020. Retrieved 14 March 2020. {{cite magazine}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  138. ^ Beeching, Nicholas J; Fletcher, Tom E; Fowler, Robert (22 May 2020). "BMJ Best Practice: Coronavirus Disease 2019 (COVID-19)" (PDF). BMJ. Archived (PDF) from the original on 13 June 2020. Retrieved 25 May 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  139. ^ Wise, Jacqui (16 December 2020). "Covid-19: New coronavirus variant is identified in UK". BMJ. 371. doi:10.1136/bmj.m4857. ISSN 1756-1833. PMID 33328153.
  140. ^ Patel-Carstairs, Sunita (19 December 2020). "COVID-19: London and South East set for Tier 4 rules - as new COVID variant 'real cause for concern'". Sky News.
  141. ^ Oberholzer M, Febbo P (19 February 2020). "What We Know Today about Coronavirus SARS-CoV-2 and Where Do We Go from Here". Genetic Engineering and Biotechnology News. Archived from the original on 14 March 2020. Retrieved 13 March 2020. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  142. ^ Ma J (13 March 2020). "Coronavirus: China's first confirmed Covid-19 case traced back to November 17". South China Morning Post. Archived from the original on 13 March 2020. Retrieved 16 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  143. ^ a b c d e f "COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)". ArcGIS. Johns Hopkins University. Retrieved 10 March 2023.
  144. ^ Coronavirus disease 2019 (COVID-19) Situation Report – 69 (Report). World Health Organization. 29 March 2020. hdl:10665/331615. {{cite report}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  145. ^ Wee SL, McNeil Jr. DG, Hernández JC (30 January 2020). "W.H.O. Declares Global Emergency as Wuhan Coronavirus Spreads". The New York Times. Archived from the original on 30 January 2020. Retrieved 30 January 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  146. ^ McKay B, Calfas J, Ansari T (11 March 2020). "Coronavirus Declared Pandemic by World Health Organization". The Wall Street Journal. Archived from the original on 11 March 2020. Retrieved 12 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  147. ^ Rocklöv J, Sjödin H, Wilder-Smith A (February 2020). "COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures". Journal of Travel Medicine. 27 (3). doi:10.1093/jtm/taaa030. PMC 7107563. PMID 32109273. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  148. ^ Dhama, Kuldeep; Khan, Sharun; Tiwari, Ruchi; Sircar, Shubhankar; Bhat, Sudipta; Malik, Yashpal Singh; et al. (24 June 2020). "Coronavirus Disease 2019–COVID-19". Clinical Microbiology Reviews. 33 (4). doi:10.1128/CMR.00028-20. ISSN 0893-8512. PMC 7405836. PMID 32580969. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  149. ^ Branswell H (30 January 2020). "Limited data on coronavirus may be skewing assumptions about severity". STAT. Archived from the original on 1 February 2020. Retrieved 13 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  150. ^ Wu JT, Leung K, Leung GM (February 2020). "Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study". The Lancet. 395 (10225): 689–697. doi:10.1016/S0140-6736(20)30260-9. PMC 7159271. PMID 32014114. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  151. ^ Boseley S, McCurry J (30 January 2020). "Coronavirus deaths leap in China as countries struggle to evacuate citizens". The Guardian. Archived from the original on 6 February 2020. Retrieved 10 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  152. ^ Paulinus A (25 February 2020). "Coronavirus: China to repay Africa in safeguarding public health". The Sun. Archived from the original on 9 March 2020. Retrieved 10 March 2020. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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Further reading

External links

Scholia has a profile for SARS-CoV-2 (Q82069695).
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