Bexlosteride

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Bexlosteride
Bexlosteride pic.png
Systematic (IUPAC) name
(4aS,10bR)-8-chloro-4-methyl-1,2,4a,5,6,10b-hexahydrobenzo[f]quinolin-
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 202189-78-4 N
ATC code None
PubChem CID 166562
ChemSpider 145762 YesY
UNII 36X732P4P0 YesY
ChEMBL CHEMBL24955 YesY
Chemical data
Formula C14H16ClNO 
Mol. mass 249.73594 g/mol
 N (what is this?)  (verify)

Bexlosteride (LY-191,704) is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride.[1][2] It is selective for the type I isoform of the enzyme.[1] It was never marketed.

Synthesis[edit]

Preparation of Bexlosteride: doi:10.1021/jo9601425

See also[edit]

References[edit]

  1. ^ a b Chang, Chawnshang (2002). Androgens and androgen receptor : mechanisms, functions, and clinical application. Boston: Kluwer Academic Publishers. ISBN 1-4020-7188-4. 
  2. ^ Lednicer, Daniel (2008). Strategies for Organic Drug Synthesis and Design. New York: Wiley-Interscience. ISBN 0-470-19039-6.