Haplogroup IWX (mtDNA)
From Wikipedia, the free encyclopedia
In human genetics, Haplogroup IWX was a human mitochondrial DNA (mtDNA) haplogroup.[1][2]
It was thought to cluster haplogroups I, W, and X.[3][4] Studies suggested haplogroup IWX to be highly protective against AIDS progression.[5] It is now known that Haplogroup I is descendent of Haplogroup N1. It has also been proposed that Haplogroup W be placed as a descendant of Haplogroup N2b.[6]
[edit] References
- ^ Maruszak A, Canter JA, Styczyńska M, Zekanowski C, Barcikowska M (November 2009). "Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?". Neurobiology of Aging 30 (11): 1749–55. doi:10.1016/j.neurobiolaging.2008.01.004. PMID 18308428.
- ^ The genome of homo sapiens
- ^ Bermisheva M, Tambets K, Villems R, Khusnutdinova E (2002). "[Diversity of mitochondrial DNA haplotypes in ethnic populations of the Volga-Ural region of Russia"] (in Russian). Molekuliarnaia Biologiia 36 (6): 990–1001. PMID 12500536. http://evolutsioon.ut.ee/publications/Bermisheva2002.pdf.
- ^ Simoni L, Calafell F, Pettener D, Bertranpetit J, Barbujani G (January 2000). "Geographic patterns of mtDNA diversity in Europe". American Journal of Human Genetics 66 (1): 262–78. doi:10.1086/302706. PMC 1288355. PMID 10631156. http://web.unife.it/progetti/genetica/Guido/pdf/11.pdf.
- ^ Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, et al. (November 2008). "Mitochondrial DNA haplogroups influence AIDS progression". AIDS (London, England) 22 (18): 2429–39. doi:10.1097/QAD.0b013e32831940bb. PMC 2699618. PMID 19005266. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2699618.
- ^ van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457.
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Evolutionary tree of Human mitochondrial DNA (mtDNA) haplogroups |
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| Mitochondrial Eve (L) | ||||||||||||||||||||||||||||||||
| L0 | L1-6 | |||||||||||||||||||||||||||||||
| L1 | L2 | L3 | L4 | L5 | L6 | |||||||||||||||||||||||||||
| M | N | |||||||||||||||||||||||||||||||
| CZ | D | E | G | Q | A | S | R | I | W | X | Y | |||||||||||||||||||||
| C | Z | B | F | R0 | pre-JT | P | U | |||||||||||||||||||||||||
| HV | JT | K | ||||||||||||||||||||||||||||||
| H | V | J | T | |||||||||||||||||||||||||||||
