Mebendazole: Difference between revisions
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==Mechanism== |
==Mechanism== |
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Mebendazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose. |
Mebendazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose. {{Cite web|url=http://www.janssen-cilag.co.uk/product/detail.jhtml?itemname=vermox_info&s=0&_requestid=668627}} |
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==Dosage== |
==Dosage== |
Revision as of 23:02, 1 August 2009
Clinical data | |
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Pregnancy category |
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Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | Hepatic |
Elimination half-life | 2.5 to 5.5 hours |
Excretion | ? |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.046.017 |
Chemical and physical data | |
Formula | C16H13N3O3 |
Molar mass | 295.293 g/mol g·mol−1 |
3D model (JSmol) | |
Melting point | 288.5 °C (551.3 °F) |
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Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.
Mechanism
Mebendazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose. http://www.janssen-cilag.co.uk/product/detail.jhtml?itemname=vermox_info&s=0&_requestid=668627. {{cite web}}
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Dosage
Oral dosage is 100 mg per dose, two doses per day, for three days.[citation needed] This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.[citation needed]
Drug interactions
Carbamazepine and Phenytoin lowers serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.[1]
Stevens-Johnson syndrome (toxic epidermal necrolysis) when Mebendazole is combined with high doses of Metronidazole.[2]
See also
External links
- Vermox (UK manufacturer's website)
References
- ^ "Drug Interactions". Retrieved 2008-05-06.. /// Luder PJ, et al. Treatment of hydatid disease with high oral doses of mebendazole: long-term follow-up of plasma mebendazole levels and drug interactions. Eur J Clin Pharmacol 1986; 31: 443–8
- ^ Chen KT, Twu SJ, Chang HJ, Lin RS (2003). "Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan". Am J Public Health. 93 (3): 489–92. doi:10.2105/AJPH.93.3.489. PMC 1447769. PMID 12604501.
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