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{{PBB|geneid=2066}}
{{PBB|geneid=2066}}


'''Receptor tyrosine-protein kinase erbB-4''' is an [[enzyme]] that in humans is encoded by the ''ERBB4'' [[gene]].<ref name="pmid7700649">{{cite journal | author = Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH | title = Localization of the human HER4/erbB-4 gene to chromosome 2 | journal = Oncogene | volume = 10 | issue = 6 | pages = 1235–7 | year = 1995 | month = May | pmid = 7700649 | pmc = | doi = }}</ref><ref name="pmid17018285">{{cite journal | author = Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G | title = Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain | journal = Cell | volume = 127 | issue = 1 | pages = 185–97 | year = 2006 | month = Oct | pmid = 17018285 | pmc = | doi = 10.1016/j.cell.2006.07.037 }}</ref> It encodes a [[receptor tyrosine kinase]] that is a member of the [[epidermal growth factor receptor]] subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple [[furin]]-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by [[neuregulin]]s-2 and -3, [[heparin-binding EGF-like growth factor]] and [[betacellulin]]. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref>{{cite web | title = Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2066| accessdate = }}</ref>
'''Receptor tyrosine-protein kinase erbB-4''' is an [[enzyme]] that in humans is encoded by the ''ERBB4'' [[gene]].<ref name="pmid7700649">{{cite journal | author = Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH | title = Localization of the human HER4/erbB-4 gene to chromosome 2 | journal = Oncogene | volume = 10 | issue = 6 | pages = 1235–7 | year = 1995 | month = May | pmid = 7700649 | pmc = | doi = }}</ref><ref name="pmid17018285">{{cite journal | author = Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G | title = Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain | journal = Cell | volume = 127 | issue = 1 | pages = 185–97 | year = 2006 | month = Oct | pmid = 17018285 | pmc = | doi = 10.1016/j.cell.2006.07.037 }}</ref> It encodes a [[receptor tyrosine kinase]] that is a member of the [[ErbB|epidermal growth factor receptor]] subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple [[furin]]-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by [[neuregulin]]s-2 and -3, [[heparin-binding EGF-like growth factor]] and [[betacellulin]]. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref>{{cite web | title = Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2066| accessdate = }}</ref>


==Interactions==
==Interactions==

Revision as of 21:44, 28 December 2009

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Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene.[1][2] It encodes a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]

Interactions

ERBB4 has been shown to interact with STAT5A,[4][5] DLG4[6][7] and YAP1.[8]

References

  1. ^ Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (1995). "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene. 10 (6): 1235–7. PMID 7700649. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (2006). "Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain". Cell. 127 (1): 185–97. doi:10.1016/j.cell.2006.07.037. PMID 17018285. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)".
  4. ^ Williams, Christopher C (2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. 167 (3). United States: 469–78. doi:10.1083/jcb.200403155. ISSN 0021-9525. PMID 15534001. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  5. ^ Schulze, Waltraud X (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1. England: 2005.0008. doi:10.1038/msb4100012. PMID 16729043. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, |laysummary=, and |month= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  6. ^ Garcia, R A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl. Acad. Sci. U.S.A. 97 (7). UNITED STATES: 3596–601. doi:10.1073/pnas.070042497. ISSN 0027-8424. PMID 10725395. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  7. ^ Huang, Y Z (2000). "Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses". Neuron. 26 (2). UNITED STATES: 443–55. ISSN 0896-6273. PMID 10839362. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  8. ^ Omerovic, Jasminka (2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. 294 (2). United States: 469–79. doi:10.1016/j.yexcr.2003.12.002. ISSN 0014-4827. PMID 15023535. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)

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