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Protein PTK6 PDB 1rja.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesPTK6, BRK, protein tyrosine kinase 6
External IDsOMIM: 602004 MGI: 99683 HomoloGene: 68494 GeneCards: PTK6
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PTK6
Genomic location for PTK6
Band20q13.33Start63,528,001 bp[1]
End63,537,376 bp[1]
RNA expression pattern
PBB GE PTK6 206482 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 63.53 – 63.54 MbChr 2: 181.19 – 181.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[5][6][7]


Tyrosine-protein kinase 6—also known as BRK[7] (breast tumor kinase)—is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[7]

Clinical significance[edit]

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[7]


PTK6 has been shown to interact with STAP2[8] and KHDRBS1.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101213 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038751 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
  6. ^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935.
  7. ^ a b c d "PTK6 protein tyrosine kinase 6". National Center for Biotechnology Information (NCBI). 4 June 2020.
  8. ^ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. ENGLAND. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601.
  9. ^ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. UNITED STATES. 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193.

Further reading[edit]