PTK6

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PTK6
Protein PTK6 PDB 1rja.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTK6, BRK, protein tyrosine kinase 6
External IDs MGI: 99683 HomoloGene: 68494 GeneCards: 5753
RNA expression pattern
PBB GE PTK6 206482 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256358
NM_005975

NM_009184

RefSeq (protein)

NP_001243287.1
NP_005966.1

NP_033210.1

Location (UCSC) Chr 20: 63.53 – 63.54 Mb Chr 2: 181.19 – 181.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[1][2][3]

Function[edit]

Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[3]

Clinical significance[edit]

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[3]

Interactions[edit]

PTK6 has been shown to interact with STAP2[4] and KHDRBS1.[5]

References[edit]

  1. ^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene 8 (12): 3403–10. PMID 8247543. 
  2. ^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935. 
  3. ^ a b c "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6". 
  4. ^ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene (ENGLAND) 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601. 
  5. ^ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. (UNITED STATES) 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193. 

Further reading[edit]