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Protein PTK6 PDB 1rja.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PTK6, BRK, protein tyrosine kinase 6
External IDs MGI: 99683 HomoloGene: 68494 GeneCards: PTK6
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PTK6
Genomic location for PTK6
Band 20q13.33 Start 63,528,001 bp[1]
End 63,537,370 bp[1]
RNA expression pattern
PBB GE PTK6 206482 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 63.53 – 63.54 Mb Chr 20: 181.19 – 181.2 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[5][6][7]


Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[7]

Clinical significance[edit]

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[7]


PTK6 has been shown to interact with STAP2[8] and KHDRBS1.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101213 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038751 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543. 
  6. ^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935. 
  7. ^ a b c "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6". 
  8. ^ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. ENGLAND. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601. 
  9. ^ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. UNITED STATES. 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087Freely accessible. PMID 10913193. 

Further reading[edit]