Leukocyte receptor tyrosine kinase

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LTK
Identifiers
AliasesLTK, TYK1, Leukocyte receptor tyrosine kinase
External IDsMGI: 96840 HomoloGene: 130502 GeneCards: LTK
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for LTK
Genomic location for LTK
Band15q15.1Start41,503,638 bp[1]
End41,513,887 bp[1]
RNA expression pattern
PBB GE LTK 207106 s at fs.png

PBB GE LTK 217184 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135685
NM_002344
NM_206961

NM_008523
NM_203345
NM_206941
NM_206942

RefSeq (protein)

NP_001129157
NP_002335
NP_996844

NP_032549
NP_976220
NP_996824
NP_996825

Location (UCSC)Chr 15: 41.5 – 41.51 MbChr 2: 119.75 – 119.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[7] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[6]

Interactions[edit]

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062524 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027297 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res. 5 (3): 199–204. PMID 2320375.
  6. ^ a b "Entrez Gene: LTK leukocyte tyrosine kinase".
  7. ^ Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN (2008). "Leukocyte tyrosine kinase functions in pigment cell development". PLoS Genet. 4 (3): e1000026. doi:10.1371/journal.pgen.1000026. PMC 2265441. PMID 18369445.
  8. ^ Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
  9. ^ Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.

Further reading[edit]