This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
^Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID10498895.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID15271258.
Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.". Oncogene. 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID9053851.
Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID10498895.