EPHA8

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EPHA8
Protein EPHA8 PDB 1ucv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006943
NM_020526

NM_007939

RefSeq (protein)

NP_001006944
NP_065387

NP_031965.2
NP_031965

Location (UCSC) Chr 1: 22.56 – 22.6 Mb Chr 4: 136.93 – 136.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.[3][4]

Function[edit]

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.[4]

Interactions[edit]

EPHA8 has been shown to interact with FYN.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID 1648701. 
  4. ^ a b "Entrez Gene: EPHA8 EPH receptor A8". 
  5. ^ Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895. 

Further reading[edit]