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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PYZRQGJRPPTADH-UHFFFAOYSA-N
| StdInChIKey = PYZRQGJRPPTADH-UHFFFAOYSA-N
}}LAMICTAL(and Seraquel) seems to be killing me slowly. watch out for these 2
}}


'''Lamotrigine''', marketed in the US and most of Europe as '''Lamictal''' ({{IPAc-en|icon|l|ə|ˈ|m|ɪ|k|t|əl}}) by [[GlaxoSmithKline]], is an [[anticonvulsant]] drug used in the treatment of [[epilepsy]] and [[bipolar disorder]]. It is also used as an adjunct in treating [[Major depressive disorder|depression]], though this is considered off-label usage.{{citation needed|date=August 2011}} For epilepsy, it is used to treat [[focal seizure]]s, primary and secondary [[tonic-clonic seizure]]s, and seizures associated with [[Lennox-Gastaut syndrome]]. Like many other anticonvulsant medications, Lamotrigine also seems to act as an effective [[mood stabilizer]], and has been the first U.S. [[Food and Drug Administration]] (FDA)-approved drug for this purpose since [[Lithium pharmacology|lithium]], a drug approved almost 30 years earlier. It is approved for the maintenance treatment of [[Bipolar disorder|bipolar type I]]. Chemically unrelated to other anticonvulsants (due to lamotrigine's being a [[phenyltriazine]]), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the [[sodium channel]] blocking class of [[antiepileptic drugs]],<ref>{{cite journal | author = Rogawski MA, Löscher W | title = The neurobiology of antiepileptic drugs | journal = Nat Rev Neurosci | volume = 5 | issue = 7 | pages = 553–564 | year = 2004 | month = Jul | pmid = 15208697 | doi=10.1038/nrn1430}}</ref> but it could have additional actions inasmuch as it has a broader spectrum of action than other sodium channel antiepileptic drugs such as [[phenytoin]] and [[carbamazepine]] and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasizes its unique properties.<ref name="pmid7687190">{{cite journal | author = Lees G, Leach MJ | title = Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex | journal = Brain Research | volume = 612 | issue = 1-2 | pages = 190–9 | year = 1993 | month = May | pmid = 7687190 | doi = 10.1016/0006-8993(93)91660-K| url = | issn = | accessdate = 2011-05-07}}</ref> Lamotrigine is inactivated by [[liver|hepatic]] [[glucuronidation]].
'''Lamotrigine''', marketed in the US and most of Europe as '''Lamictal''' ({{IPAc-en|icon|l|ə|ˈ|m|ɪ|k|t|əl}}) by [[GlaxoSmithKline]], is an [[anticonvulsant]] drug used in the treatment of [[epilepsy]] and [[bipolar disorder]]. It is also used as an adjunct in treating [[Major depressive disorder|depression]], though this is considered off-label usage.{{citation needed|date=August 2011}} For epilepsy, it is used to treat [[focal seizure]]s, primary and secondary [[tonic-clonic seizure]]s, and seizures associated with [[Lennox-Gastaut syndrome]]. Like many other anticonvulsant medications, Lamotrigine also seems to act as an effective [[mood stabilizer]], and has been the first U.S. [[Food and Drug Administration]] (FDA)-approved drug for this purpose since [[Lithium pharmacology|lithium]], a drug approved almost 30 years earlier. It is approved for the maintenance treatment of [[Bipolar disorder|bipolar type I]]. Chemically unrelated to other anticonvulsants (due to lamotrigine's being a [[phenyltriazine]]), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the [[sodium channel]] blocking class of [[antiepileptic drugs]],<ref>{{cite journal | author = Rogawski MA, Löscher W | title = The neurobiology of antiepileptic drugs | journal = Nat Rev Neurosci | volume = 5 | issue = 7 | pages = 553–564 | year = 2004 | month = Jul | pmid = 15208697 | doi=10.1038/nrn1430}}</ref> but it could have additional actions inasmuch as it has a broader spectrum of action than other sodium channel antiepileptic drugs such as [[phenytoin]] and [[carbamazepine]] and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasizes its unique properties.<ref name="pmid7687190">{{cite journal | author = Lees G, Leach MJ | title = Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex | journal = Brain Research | volume = 612 | issue = 1-2 | pages = 190–9 | year = 1993 | month = May | pmid = 7687190 | doi = 10.1016/0006-8993(93)91660-K| url = | issn = | accessdate = 2011-05-07}}</ref> Lamotrigine is inactivated by [[liver|hepatic]] [[glucuronidation]].

Revision as of 20:54, 11 May 2012

Lamotrigine
Clinical data
Trade namesLamictal
AHFS/Drugs.comMonograph
MedlinePlusa695007
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability98%
Protein binding55%
MetabolismHepatic (mostly UGT1A4-mediated)
Elimination half-life24–34 hours (healthy adults)
ExcretionRenal
Identifiers
  • 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.074.432 Edit this at Wikidata
Chemical and physical data
FormulaC9H7Cl2N5
Molar mass256.091 g/mol g·mol−1
3D model (JSmol)
  • Clc2c(Cl)c(c1nnc(nc1N)N)ccc2
  • InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) checkY
  • Key:PYZRQGJRPPTADH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

LAMICTAL(and Seraquel) seems to be killing me slowly. watch out for these 2

Lamotrigine, marketed in the US and most of Europe as Lamictal (/[invalid input: 'icon']ləˈmɪktəl/) by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used as an adjunct in treating depression, though this is considered off-label usage.[citation needed] For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, Lamotrigine also seems to act as an effective mood stabilizer, and has been the first U.S. Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants (due to lamotrigine's being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[2] but it could have additional actions inasmuch as it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasizes its unique properties.[3] Lamotrigine is inactivated by hepatic glucuronidation.

Medical uses

Epilepsy and seizures

Lamotrigine is approved in the US for the treatment of partial seizures.[4] Lamotrigine is one of a small number of FDA-approved therapies for seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. Typically developing before four years of age, LGS is associated with developmental delays. There is no cure, treatment is often complicated, and complete recovery is rare. Symptoms include the atonic seizure (also known as a "drop attack"), during which brief loss of muscle tone and consciousness cause abrupt falls. Lamotrigine significantly reduces the frequency of LGS seizures, and is one of two medications known to decrease the severity of drop attacks.[5] Combination with valproate is common, but this increases the risk of lamotrigine-induced rash, and necessitates reduced dosing due to the interaction of these drugs.[6]

Bipolar disorder

Lamotrigine is approved in the US for maintenance treatment of Bipolar I disorder.[7] While traditional anticonvulsant drugs are predominantly antimanics, lamotrigine is most effective for preventing the recurrent depressive episodes of bipolar disorder. The drug seems ineffective in the maintenance of rapid-cycling bipolar disorder;[8] however, according to studies in 2007, lamotrigine may treat bipolar depression without triggering mania, hypomania, mixed states, or rapid-cycling.[9]

There is less evidence of therapeutic benefit when lamotrigine is used to treat a preexisting mood episode. It has not demonstrated effectiveness in treating acute mania,[10] and there is controversy regarding the drug’s effectiveness in treating acute bipolar depression. While the 2002 American Psychiatric Association (APA) guidelines recommend lamotrigine as a first-line treatment for acute depression in Bipolar II disorder,[11] the APA’s website notes that the guidelines, being more than five years old, “can no longer be assumed to be current."[12] A paper written in 2008 by Nasser et al. reviewed evidence from trials that were unpublished and not referenced in the 2002 APA guidelines, and it concludes that lamotrigine has "very limited, if any, efficacy in the treatment of acute bipolar depression."[8] A 2008 paper by Calabrese et al. examined much of the same data, and found that in five placebo controlled studies, lamotrigine did not significantly differ from placebo in the treatment of bipolar depression.[13] However, in a meta-analysis of these studies conducted in 2008, Calabrese found that lamotrigine was effective in individuals with bipolar depression, with a number needed to treat (NNT) of 11, or 7 in severe depression.[14]

Other uses

Off-label uses include the treatment of peripheral neuropathy, trigeminal neuralgia, cluster headaches, migraines, and reducing neuropathic pain. [15][16][17] Off-label psychiatric usage includes the treatment of depersonalization disorder, bipolar II disorder and other bipolar disorders, schizoaffective disorder, borderline personality disorder and post-traumatic stress disorder.[citation needed] Lamotrigine has been studied as an adjunctive therapy for treatment of refractory unipolar depression, attaining efficacy on the secondary metric for treatment outcomes (Clinical Global Impressions), but not the primary metrics (Montgomery-Åsberg Depression Rating Scale and Hamilton Rating Scale for Depression).[18]

Mechanism of action

Lamotrigine, 150 mg tablet.

Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs.[19] Early studies of lamotrigine's mechanism of action examined its effects on the release of endogenous amino acids from rat cerebral cortex slices in vitro. As is the case for antiepileptic drugs that act on voltage-dependent sodium channels, lamotrigine inhibited the release of glutamate and aspartate evoked by the sodium-channel activator veratrine and was less effective in the inhibition of acetylcholine or GABA release. At high concentrations, it had no effect on spontaneous or potassium evoked amino acid release. These studies suggested that lamotrigine acts presynaptically on voltage-gated sodium channels to decrease glutamate release. Several electrophysiological studies have investigated the effects of lamotrigine on voltage-dependent sodium channels. For example, lamotrigine blocked sustained repetitive firing in cultured mouse spinal cord neurons in a concentration-dependent manner at concentrations therapeutic in the treatment of human seizures. In cultured hippocampal neurons, lamotrigine reduced sodium currents in a voltage-dependent manner, and at depolarized potentials showed a small frequency-dependent inhibition. These and a variety of other results indicate that the antiepileptic effect of lamotrigine, like that of phenytoin and carbamazepine, is at least in part due to use- and voltage-dependent modulation of fast voltage-dependent sodium currents. However, lamotrigine has a broader clinical spectrum of activity than phenytoin and carbamazepine and is recognized to be protective against generalized absence epilepsy and other generalized epilepsy syndromes, including primary generalized tonic–clonic seizures, juvenile myoclonic epilepsy, and Lennox-Gastaut syndrome. The basis for the broader spectrum of activity of lamotrigine is unknown, but could relate to actions of the drug on voltage-activated calcium channels. Lamotrigine blocks T-type calcium channels weakly, if at all. However, it does inhibit native and recombinant high-voltage–activated calcium channels (N- and P/Q/R-types) at therapeutic concentrations. Whether this activity on calcium channels accounts for lamotrigine's broader clinical spectrum of activity in comparison with phenytoin and carbamazepine remains to be determined.

Pharmacokinetics

The pharmacokinetics of lamotrigine follow first-order kinetics, with a half-life of 13.5 hours and volume of distribution of 1.36 L/kg.[20] Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme inducing medications may shorten half-life. Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance.

Side-effects

Lamotrigine prescribing information has a black box warning about life-threatening skin reactions, including Stevens–Johnson syndrome, DRESS syndrome and toxic epidermal necrolysis.[21] The manufacturer states that nearly all cases appear in the first 2 to 8 weeks of therapy and if medication is suddenly stopped then resumed at the normal dosage. Patients should seek medical attention for any unexpected skin rash, as its presence is an indication of a possible serious or even deadly side-effect of the drug. Not all rashes that occur while taking lamotrigine progress to SJS or TEN. Between 5 to 10% of patients will develop a rash, but only one in a thousand patients will develop a serious rash. It is thought that one in 50,000 exposed patients may die from the rash.[citation needed] Rash and other skin reactions are more common in children, so this medication is often reserved for adults.

There is also an increased incidence of these eruptions in patients who are currently on, or recently discontinued a valproate-type anticonvulsant drug, as these medications interact in such a way that the clearance of both is decreased and the effective dose of lamotrigine is increased.

As of December 2010, lamotrigine carries an FDA black box warning for aseptic meningitis.[22]

Side-effects such as rash, fever, and fatigue are very serious, as they may indicate incipient Stevens–Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome or aseptic meningitis.[22]

Other side-effects include loss of balance or coordination, double vision, crossed eyes, blurred vision, dizziness and lack of coordination, drowsiness, insomnia, anxiety, vivid dreams or nightmares, dry mouth, mouth ulcers,[citation needed] memory and cognitive problems, mood changes, runny nose, cough, nausea, indigestion, abdominal pain, weight loss, missed or painful menstrual periods, and vaginitis. The side-effect profile is different for different patient populations.[22]

Lamotrigine has been associated with a decrease in white blood cell count (leucopenia).[23] Lamotrigine does not prolong QT/QTc in TQT studies in healthy subjects [24]

Effects in women

In clinical trials women were more likely than men to have side-effects[citation needed]. This is the opposite of most other anticonvulsants and antipsychotics.

There is evidence showing interactions between lamotrigine and female hormones, which can be of particular concern for women on estrogen-containing hormonal contraceptives. Ethinyl estradiol, the ingredient of such contraceptives, has been shown to decrease serum levels of lamotrigine.[25] Women starting an estrogen-containing oral contraceptive may need to increase the dosage of lamotrigine to maintain its level of efficacy. Likewise, women may experience an increase in lamotrigine side-effects upon discontinuation of the pill. This may include the "pill free" week where lamotrigine serum levels have been shown to increase twofold.[21] Another study showed a significant increase in follicle stimulating hormone (FSH) and luteinizing hormone (LH) in women taking lamotrigine with oral contraceptive compared to women taking oral contraceptives alone.[26] However, these increases were not in conjunction with increased progesterone, indicating that oral contraceptives maintained suppression of ovulation.[26]

Pregnancy and breastfeeding

Lamotrigine is rated Pregnancy Category Risk C. Use during pregnancy is recommended only if benefits outweigh potential risks. In September 2006, the FDA issued a warning stating that taking lamotrigine during the first trimester of pregnancy may increase the risk for cleft lip and palate malformation in newborns.[27] Since then, review studies have found that overall rates of congenital malformations in infants exposed to lamotrigine in utero are relatively low (1-4%).[28][29] This compares to a typical 3% rate in the untreated population. A prospective study on cognition in children (mean age = 4.2 years) exposed to lamotrigine in utero did not indicate any adverse effects.[30]

Lamotrigine is found in breast milk; the manufacturer does not recommend breastfeeding during treatment. In "Medications and Mothers' Milk", a frequently updated review of scientific literature, lamotrigine is rated as L3: moderately safe.[31]

Other types of effects

Lamotrigine binds to melanin-containing tissues such as the iris of the eye. The long-term consequences of this are unknown.[32]

Some patients have reported experiencing a loss of concentration, even with very small doses, while some others have actually reported an increase in alertness and concentration. GlaxoSmithKline investigated lamotrigine for the treatment of ADHD. The results were inconclusive. No detrimental effects on cognitive function were observed; however, the only statistical improvement in core ADHD symptoms was an improvement on a test, PASAT (Paced Auditory Serial Addition Test), that measures auditory processing speed and calculation ability.[33]

Lamotrigine is known to affect sleep. Studies with small numbers (10-15) of patients reported that lamotrigine increases sleep stability (increases the duration of REM sleep, decreases the number of phase shifts, and decreases the duration of slow-wave sleep),[34] and that there was no effect on vigilance,[35] and daytime somnolence and cognitive function.[36] However, a retrospective study of 109 patients' medical records found that 6.7% of patients experienced an 'alerting effect' resulting in intolerable insomnia, for which the treatment had to be discontinued.[37]

Lamotrigine can induce a type of seizure known as a myoclonic jerk, which tends to happen soon after the use of the medication.[38] When used in the treatment of myoclonic epilepsies such as juvenile myoclonic epilepsy, lower doses (and lower plasma levels) are usually needed, as even moderate doses of this drug can lead to induction of seizures, including tonic-clonic seizures, which can develop into status epilepticus, which is a medical emergency. It can also cause myoclonic status epilepticus.[citation needed]

In overdose, lamotrigine can cause uncontrolled seizures in most people.

History

  • December 1994 — Lamotrigine was approved for the treatment of partial seizures.[4]
  • August 1998 — for use as adjunctive treatment of Lennox-Gastaut syndrome in pediatric and adult patients, new dosage form: chewable dispersible tablets.
  • December 1998 — for use as monotherapy for treatment of partial seizures in adult patients when converting from a single enzyme-inducing anti-epileptic drug (EIAED).
  • January 2003 — for use as adjunctive therapy for partial seizures in pediatric patients as young as 2 years of age.
  • June 2003 — Lamotrigine approved for maintenance treatment of Bipolar I disorder; the first since lithium.[7]
  • January 2004 — for use as monotherapy for treatment of partial seizures in adult patients when converting from the anti-epileptic drug valproate (including valproic acid (Depakene); sodium valproate (Epilim) and divalproex sodium (Depakote)).

Availability

Lamictal 200 mg tablets

GlaxoSmithKline's trademarked brand of lamotrigine, Lamictal, is manufactured in scored tablets (25 mg, 50 mg, 100 mg, 150 mg and 200 mg) and chewable dispersible tablets (2 mg, 5 mg and 25 mg). Five-week sample kits are also available; these include titration instructions and scored tablets (25 mg for patients taking valproate, 25 mg and 100 mg for patients not taking valproate). Lamotrigine is also available in un-scored tablet form. In 2005, Teva Pharmaceutical Industries Ltd. began selling generic lamotrigine in the United States, but only in 5 mg and 25 mg chewable dispersible tablets.[39] On 23 July 2008 Teva began offering the full line of generic lamotrigine in the US.[40] Lamotrigine is also available in generic form[41] in the United States, the United Kingdom, Canada and Australia. It should be noted that brand name Lamictal is not available in 200 mg tablets in Canada, at all registered pharmacies (while 25, 100, and 150 mg are all offered). Starter kits are also not available in Canada.

Lamotrigine is marketed as Lamitrin in Bangladesh [1], Lamictin in South Africa, למוג'ין (Lamogine)[42] in Israel, and 라믹탈 in South Korea and generally named as Lamitor.

Lamictal XR

In 2009 GlaxoSmithKline received FDA Approval for an extended-release version of lamotrigine branded Lamictal XR.[43] Lamictal XR tablets are a novel preparation of lamotragine, delivered in a tablet with an enteric coating that GlaxoSmithKline has branded DiffCORE. The extended release formulation is analogous to the instant release version, such that treatment may begin without titration or recalibration of the dosage.

In Japan, Lamotrigine is classified as a narcotic and prior to entering the country a proper license must be obtained from the patient's country's Japanese embassy. [citation needed]

Chemistry

U.S. patent 4,560,687

References

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ Rogawski MA, Löscher W (2004). "The neurobiology of antiepileptic drugs". Nat Rev Neurosci. 5 (7): 553–564. doi:10.1038/nrn1430. PMID 15208697. {{cite journal}}: Unknown parameter |month= ignored (help)
  3. ^ Lees G, Leach MJ (1993). "Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex". Brain Research. 612 (1–2): 190–9. doi:10.1016/0006-8993(93)91660-K. PMID 7687190. {{cite journal}}: |access-date= requires |url= (help); Unknown parameter |month= ignored (help)
  4. ^ a b anonymous (19 March 2004). "EFFICACY SUPPLEMENTS APPROVED IN CALENDAR YEAR 2003". FDA/Center for Drug Evaluation and Research. Retrieved 2008-04-09.
  5. ^ French JA, Kanner AM, Bautista J; et al. (2004). "Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society". Neurology. 62 (8): 1261–73. doi:10.1212/01.WNL.0000123695.22623.32. PMID 15111660. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. ^ Pellock JM (1999). "Managing pediatric epilepsy syndromes with new antiepileptic drugs". Pediatrics. 104 (5 Pt 1): 1106–16. doi:10.1542/peds.104.5.1106. PMID 10545555. {{cite journal}}: Unknown parameter |month= ignored (help)
  7. ^ a b GlaxoSmithKline, 2003
  8. ^ a b Ghaemi, S.N., Shirzadi, A.A., Filkowski, M. (2008). "Publication Bias and the Pharmaceutical Industry: The Case of Lamotrigine in Bipolar Disorder". Medscape J Med. 10 (9): 211. PMC 2580079. PMID 19008973.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Goldberg JF, Calabrese JR, Saville BR, Frye MA, Ketter TA, Suppes T, Post RM, Goodwin FK. (2009). "Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo". Clinical Psychiatry. 70 (9): 1273–80. doi:10.4088/JCP.08m04381. PMID 19689918.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ^ Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM (2003). "Lamotrigine: a review of its use in bipolar disorder". Drugs. 63 (19): 2029–50. PMID 12962521.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ "Acute Treatment — Formula and Implementation of a Treatment Plan". Practice Guideline for the Treatment of Patients With Bipolar Disorder Second Edition. American Psychiatric Association. Retrieved 15 August 2010.
  12. ^ "Main page". Practice Guideline for the Treatment of Patients With Bipolar Disorder Second Edition. American Psychiatric Association. Retrieved 15 August 2010.
  13. ^ Calabrese JR, Huffman RF, White RL, Edwards S, Thompson TR, Ascher JA, Monaghan ET, Leadbetter RA (2008). "Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials". Bipolar disorders. 10 (2): 323–333. doi:10.1111/j.1399-5618.2007.00500.x. PMID 18271912.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ Calabrese JR, Geddes JR, Goodwin GM (2009). "Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials". British Journal of Psychiatry. 194 (1): 4–9.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  15. ^ Backonja M (2004). "Neuromodulating drugs for the symptomatic treatment of neuropathic pain". Curr Pain Headache Rep. 8 (3): 212–6. doi:10.1007/s11916-004-0054-4. PMID 15115640. {{cite journal}}: Unknown parameter |month= ignored (help)
  16. ^ Jensen TS (2002). "Anticonvulsants in neuropathic pain: rationale and clinical evidence". Eur J Pain. 6 (Suppl A): 61–8. doi:10.1053/eujp.2001.0324. PMID 11888243.
  17. ^ Pappagallo M (2003). "Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine". Clin Ther. 25 (10): 2506–38. doi:10.1016/S0149-2918(03)80314-4. PMID 14667954. {{cite journal}}: Unknown parameter |month= ignored (help)
  18. ^ Barbosa L, Berk M, Vorster M (2003). "A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes" (PDF). J Clin Psychiatry. 64 (4): 403–7. doi:10.4088/JCP.v64n0407. PMID 12716240. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  19. ^ Rogawski, M (2002). "Chapter 1: Principles of antiepileptic drug action". In Levy RH, Mattson RH, Meldrum BS, Perucca E (ed.). Antiepileptic Drugs, Fifth Edition. Lippincott Williams & Wilkins. pp. 3–22. ISBN [[Special:BookSources/10781723213|10781723213[[Category:Articles with invalid ISBNs]]]]. {{cite book}}: Check |isbn= value: invalid character (help)CS1 maint: multiple names: editors list (link)
  20. ^ Ramsay RE, Pellock JM, Garnett WR; et al. (1991). "Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy". Epilepsy Res. 10 (2–3): 191–200. doi:10.1016/0920-1211(91)90012-5. PMID 1817959. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  21. ^ a b "Lamictal Prescribing Information" (PDF). GlaxoSmithKline. 2007. Retrieved 2008-04-09. {{cite web}}: Unknown parameter |month= ignored (help)
  22. ^ a b c http://www.drugs.com/monograph/lamotrigine.html
  23. ^ Nicholson, R J (25 February 1995). "Leucopenia associated with lamotrigine". BMJ. Retrieved 16 June 2010. {{cite web}}: More than one of |author= and |last= specified (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  24. ^ Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjectsDixon, Ruth (July 2008). "Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects". Br J Clin Pharmacol 2008. 66 (3): 396–404. doi:10.1111/j.1365-2125.2008.03250.x. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  25. ^ Reimers A, A (September 2005). "Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations". Epilepsia. 46 (9). Blackwell Science: 1414–7. doi:10.1111/j.1528-1167.2005.10105.x. PMID 16146436. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  26. ^ a b Sidhu J, J (February 2006). "The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects". Br J Clin Pharmacol. 61 (2): 191–9. doi:10.1111/j.1365-2125.2005.02539.x. PMC 1885007. PMID 16433873. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  27. ^ FDA: Safety Alerts: Lamotrigine
  28. ^ Berwaerts, K (2009). "Teratogenic effects of lamotrigine in women with bipolar disorder". Tijdschr Psychiatr (in Dutch). 51 (10): 741–50. PMID 19821242. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  29. ^ Prakash (October 2007). "Lamotrigine in pregnancy: safety profile and the risk of malformations". Singapore Med J. 48 (10): 880–3. PMID 17909669. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
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