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MS4A2

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MS4A2
Identifiers
AliasesMS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDsOMIM: 147138; MGI: 95495; HomoloGene: 112; GeneCards: MS4A2; OMA:MS4A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000139
NM_001142303
NM_001256916

NM_001276328
NM_001276329
NM_001276330
NM_013516

RefSeq (protein)

NP_000130
NP_001243845

NP_001263257
NP_001263258
NP_001263259
NP_038544

Location (UCSC)Chr 11: 60.09 – 60.1 MbChr 19: 11.59 – 11.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.[5][6]

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149534Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024680Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett. 302 (2): 161–5. doi:10.1016/0014-5793(92)80430-O. PMID 1386024. S2CID 44791683.
  6. ^ a b "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.