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The station was founded on October 22, 1993. It signed on as translator K38EA on channel 38, before moving to channel 48 as KHTV-LP, starting in 2000 as an affiliate of now defunct Home Shopping en Español, later rebranding to HSE (Spanish-language channel operated by parent channel Home Shopping Network) until HSE ceased operations in June 2002. When KOCE launched its digital signal on channel 48, this displaced KHTV-LP to channel 67. It stayed on channel 67 until December 31, 2011, when the last of the LPTV stations still using out-of-core channels 52-69 had to vacate that spectrum. In 2012, KHTV-LP converted to digital as KHTV-LD and moved to channel 27. On July 11, 2012, the station received class A status and changed its call sign to KHTV-CD. In 2019, as part of the repack, KHTV-CD moved to its current channel 22 allocation, channel sharing with MeTV owned-and-operated station KAZA-TV.
The KHTV call letters were originally used by an unrelated full-power station in Portland, Oregon on channel 27, and in Houston, Texas on channel 39, now KIAH.