Algestone acetophenide

Algestone acetophenide
Clinical data
Other names	16α,17α-Dihydroxyprogesterone acetophenide
Routes of; administration	Subcutaneous
ATC code	None;
Identifiers
CAS Number	24356-94-3;
PubChem CID	5284538;
ChemSpider	4447595;
ChEBI	CHEBI:49327;
CompTox Dashboard (EPA)	DTXSID1022891 ;
ECHA InfoCard	100.041.981
Chemical and physical data
Formula	C29H36O4
Molar mass	448.59 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C)[C@]25O[C@@](O[C@@H]5C[C@H]1[C@H]4[C@H](CC[C@@]12C)[C@@]3(/C(=C\C(=O)CC3)CC4)C)(c6ccccc6)C;
	InChI InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1; Key:AHBKIEXBQNRDNL-FVCOMRFXSA-N;

Algestone acetophenide (USAN) (brand names Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), also known as dihydroxyprogesterone acetophenide (DHPA), is a steroidal progestin of the 17α-hydroxyprogesterone group that is used as a contraceptive.^[1]^[2] It is marketed in combination with estradiol enanthate as a combined injectable contraceptive.^[3]^[4]^[5] The drug is the ketal formed between algestone and acetophenone.^[1]^[2] It is also described as a corticosteroid, similarly to other 17α-hydroxyprogesterone derivatives.^[1] Algestone acetophenide is said to be both more potent and longer-acting than hydroxyprogesterone caproate.^[6]

References

^ ^a ^b ^c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 27–. ISBN 978-1-4757-2085-3.
^ ^a ^b William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 153–. ISBN 978-0-8155-1856-3.
^ Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.
^ http://www.wjpps.com/download/article/1412071798.pdf
^ Rowlands, S (2009). "New technologies in contraception". BJOG: An International Journal of Obstetrics & Gynaecology. 116 (2): 230–239. doi:10.1111/j.1471-0528.2008.01985.x. ISSN 1470-0328.
^ Kawakami M, Sawyer CH (1967). "Effects of sex hormones and antifertility steroids in brain thresholds in the rabbit". Endocrinology. 80 (5): 857–71. doi:10.1210/endo-80-5-857. PMID 4164655.

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