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Ardem Patapoutian

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Ardem Patapoutian
Born1967 (age 56–57)
Beirut, Lebanon
Occupations
  • Molecular biologist
  • neuroscientist
AwardsNobel Prize for Medicine (2021)
Academic background
Education
Academic work
InstitutionsScripps Research

Ardem Patapoutian (Armenian: Արտեմ Փաթափութեան, born 1967 in Beirut, Lebanon) is a Armenian-American molecular biologist and neuroscientist of Armenian descent at Scripps Research in La Jolla, California. He won the Nobel Prize for Medicine in 2021.[1]

Education

Patapoutian attended the American University of Beirut before emigrating to the United States in 1986. He received a bachelor's degree in cell and developmental biology from the University of California, Los Angeles in 1990 and a Ph.D. in biology from the California Institute of Technology in 1996. As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the University of California, San Francisco. In 2000, he became an assistant professor at the Scripps Research Institute. Between 2000 and 2014 he had an additional research position for the Novartis Research Foundation. Since 2014 Patapoutian has been an investigator for the Howard Hughes Medical Institute (HHMI).[2]

Research and career

Patapoutian researches the signal transduction of sensors. He made significant contributions to the identification of novel ion channels and receptors that are activated by temperature, mechanical forces or increased cell volume. Patapoutian and co-workers were able to show that these ion channels play an outstanding role in the sensation of temperature, in the sensation of touch, in proprioception, in the sensation of pain and in the regulation of vascular tone. More recent work uses functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction).[citation needed]

Awards and honors

According to Google Scholar, Patapoutian has an h-index of 68,[3] according to the Scopus one of 63[4] (as of May 2020). He has been a Fellow of the American Association for the Advancement of Science since 2016, a member of the National Academy of Sciences since 2017 [5] and of the American Academy of Arts and Sciences since 2020.[6] In 2017 Patapoutian received the W. Alden Spencer Award,[7] in 2019 the Rosenstiel Award,[8] in 2020 the Kavli Prize for Neuroscience[9] and the BBVA Foundation Frontiers of Knowledge Award in Biology / Biomedicine.[10]

In 2021 he was awarded the Nobel Prize in Physiology or Medicine jointly with David Julius for their discoveries of receptors for temperature and touch.[11]

Publications

  • LRRC8 proteins form volume-regulated anion channels that sense ionic strength.[12]
  • Piezo2 is the major transducer of mechanical forces for touch sensation in mice.[13]
  • Qiu, Zhaozhu; Dubin, Adrienne E.; Mathur, Jayanti; Tu, Buu; Reddy, Kritika; Miraglia, Loren J.; Reinhardt, Jürgen; Orth, Anthony P.; Patapoutian, Ardem (2014). "SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel". Cell. 157 (2). Elsevier BV: 447–458. doi:10.1016/j.cell.2014.03.024. ISSN 0092-8674.
  • Woo, Seung-Hyun; Ranade, Sanjeev; Weyer, Andy D.; Dubin, Adrienne E.; Baba, Yoshichika; Qiu, Zhaozhu; Petrus, Matt; Miyamoto, Takashi; Reddy, Kritika; Lumpkin, Ellen A.; Stucky, Cheryl L.; Patapoutian, Ardem (6 April 2014). "Piezo2 is required for Merkel-cell mechanotransduction". Nature. 509 (7502). Springer Science and Business Media LLC: 622–626. doi:10.1038/nature13251. ISSN 0028-0836.
  • Coste, Bertrand; Xiao, Bailong; Santos, Jose S.; Syeda, Ruhma; Grandl, Jörg; Spencer, Kathryn S.; Kim, Sung Eun; Schmidt, Manuela; Mathur, Jayanti; Dubin, Adrienne E.; Montal, Mauricio; Patapoutian, Ardem (19 February 2012). "Piezo proteins are pore-forming subunits of mechanically activated channels". Nature. 483 (7388). Springer Science and Business Media LLC: 176–181. doi:10.1038/nature10812. ISSN 0028-0836.
  • Kim, Sung Eun; Coste, Bertrand; Chadha, Abhishek; Cook, Boaz; Patapoutian, Ardem (19 February 2012). "The role of Drosophila Piezo in mechanical nociception". Nature. 483 (7388). Springer Science and Business Media LLC: 209–212. doi:10.1038/nature10801. ISSN 0028-0836.
  • Coste, B.; Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E.; Patapoutian, A. (2 September 2010). "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels". Science. 330 (6000). American Association for the Advancement of Science (AAAS): 55–60. doi:10.1126/science.1193270. ISSN 0036-8075.

References

  1. ^ "David Julius, Ardem Patapoutian win 2021 Nobel Prize in Medicine for discoveries of receptors for temperature and touch". India Today. Retrieved 2021-10-04.
  2. ^ "Ardem Patapoutian". www.kavliprize.org. March 12, 2021.
  3. ^ Ardem Patapoutian publications indexed by Google Scholar Edit this at Wikidata
  4. ^ "Patapoutian, Ardem". scopus.com. Scopus.
  5. ^ "Ardem Patapoutian". www.nasonline.org.
  6. ^ "Members Elected in 2020". American Academy of Arts & Sciences.
  7. ^ "The Thirty-Ninth Annual W. Alden Spencer Award and Lecture". Kavli Institute for Brain Science. June 4, 2020.
  8. ^ "Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research". www.brandeis.edu.
  9. ^ "2020 Kavli Prize in Neuroscience". www.kavliprize.org. March 12, 2021.
  10. ^ "Fundación BBVA". FBBVA.
  11. ^ "The Nobel Prize in Physiology or Medicine 2021". NobelPrize.org. Retrieved 2021-10-04.
  12. ^ Syeda, Ruhma; Qiu, Zhaozhu; Dubin, Adrienne E.; Murthy, Swetha E.; Florendo, Maria N.; Mason, Daniel E.; Mathur, Jayanti; Cahalan, Stuart M.; Peters, Eric C.; Montal, Mauricio; Patapoutian, Ardem (2016-01-28). "LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength". Cell. 164 (3): 499–511. doi:10.1016/j.cell.2015.12.031. ISSN 1097-4172. PMC 4733249. PMID 26824658.
  13. ^ Ranade, Sanjeev S.; Woo, Seung-Hyun; Dubin, Adrienne E.; Moshourab, Rabih A.; Wetzel, Christiane; Petrus, Matt; Mathur, Jayanti; Bégay, Valérie; Coste, Bertrand; Mainquist, James; Wilson, A. J. (December 2014). "Piezo2 is the major transducer of mechanical forces for touch sensation in mice". Nature. 516 (7529): 121–125. doi:10.1038/nature13980. ISSN 1476-4687.
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