18 August 1932
|Alma mater||University of Paris|
|Known for||Discoverer of HIV|
Luc Montagnier (US: / /,; US: /-/, French: [mɔ̃taɲe]; born 18 August 1932) is a French virologist and joint recipient, with Françoise Barré-Sinoussi and Harald zur Hausen, of the 2008 Nobel Prize in Physiology or Medicine for his discovery of the human immunodeficiency virus (HIV). He has worked as a researcher at the Pasteur Institute in Paris and as a full-time professor at Shanghai Jiao Tong University in China.
During the COVID-19 pandemic, Montagnier was a promoter of the conspiracy theory that SARS-CoV-2, the causative virus, was deliberately created in, and thereafter escaped from a laboratory. Such a claim has been refuted by other virologists. He has been criticised by other academics for using his Nobel prize status to "spread dangerous health messages outside his field of knowledge".
History of the discovery of HIV
In 1982, Willy Rozenbaum, a clinician at the Hôpital Bichat hospital in Paris, asked Montagnier for assistance in establishing the cause of a mysterious new syndrome, AIDS (known at the time as "gay-related immune deficiency" or GRID). Rozenbaum had suggested at scientific meetings that the cause of the disease might be a retrovirus. Montagnier and members of his group at the Pasteur Institute, notably including Françoise Barré-Sinoussi and Jean-Claude Chermann, had extensive experience with retroviruses. Montagnier and his team examined samples taken from Rozenbaum's AIDS patients and found the virus that would later become known as HIV in a lymph node biopsy. They named it "lymphadenopathy-associated virus", or LAV, since it was not then clear that it was the cause of AIDS, and published their findings in the journal Science on 20 May 1983.
A team led by Robert Gallo of the United States published similar findings in the same issue of Science and later confirmed the discovery of the virus and presented evidence that it caused AIDS. Gallo called the virus "human T-lymphotropic virus type III" (HTLV-III) because of perceived similarities with HTLV-I and -II, which had previously been discovered in his lab. Because of the timing of the discoveries, whether Montagnier's or Gallo's group was first to isolate HIV was for many years the subject of an acrimonious dispute. HIV isolates usually have a high degree of variability because the virus mutates rapidly. In comparison, the first two-human immunodeficiency virus type 1 (HIV-1) isolates, Lai/LAV (formerly LAV, isolated at the Pasteur Institute) and Lai/IIIB (formerly HTLV-IIIB, isolated from a pooled culture at the Laboratory of Tumor Cell Biology (LTCB) of the National Cancer Institute) were strikingly similar in sequence, suggesting that the two isolates were in fact the same, or at least shared a common source.
In November 1990, the Office of Scientific Integrity at the National Institutes of Health attempted to clear up the matter by commissioning a group at Roche to analyze archival samples established at the Pasteur Institute and the Laboratory of Tumor Cell Biology (LTCB) of the National Cancer Institute between 1983 and 1985. The group, led by American epidemiologist Sheng-Yung Chang, examined archival specimens and concluded in Nature in 1993 that the American sample in fact originated from the French lab.
Chang determined that the French group's LAV was a virus from one patient that had contaminated a culture from another. On request, Montagnier's group had sent a sample of this culture to Gallo, not knowing it contained two viruses. It then contaminated the pooled culture on which Gallo was working.
Before the 1993 publication of Chang's results, Gallo's lab was accused and initially found guilty of "minor misconduct" by the Office of Scientific Integrity in 1991, and then by the newly created Office of Research Integrity in 1992 for the misappropriation of a sample of HIV produced at the Pasteur Institute. The subsequent publication in 1993 of Chang's investigation cleared Gallo's lab of the charges, although his reputation had already been tainted by the accusations.
Today it is agreed that Montagnier's group first isolated HIV, but Gallo's group is credited with discovering that the virus causes AIDS and with generating much of the science that made the discovery possible, including a technique previously developed by Gallo's lab for growing T cells in the laboratory. When Montagnier's group first published their discovery, they said HIV's role in causing AIDS "remains to be determined."
The question of whether the true discoverers of the virus were French or American was more than a matter of prestige. A US government patent for the AIDS test, filed by the United States Department of Health and Human Services and based on what was claimed to be Gallo's identification of the virus, was at stake. In 1987, both governments attempted to end the dispute by arranging to split the prestige of the discovery and the proceeds from the patent 50–50, naming Montagnier and Gallo co-discoverers. The two scientists continued to dispute each other's claims until 1987.
It was not until French President François Mitterrand and American President Ronald Reagan met in person that the major issues were ironed out. The scientific protagonists finally agreed to share credit for the discovery of HIV, and in 1986, both the French and the US names (LAV and HTLV-III) were dropped in favor of the new term human immunodeficiency virus (virus de l'immunodéficience humaine, abbreviated HIV or VIH) (Coffin, 1986). They concluded that the origin of the HIV-1 Lai/IIIB isolate discovered by Gallo was the same as that discovered by Montagnier (but not known by Montagnier to cause AIDS). This compromise allowed Montagnier and Gallo to end their feud and collaborate with each other again, writing a chronology that appeared in Nature that year.
On 29 November 2002 issue of Science, Gallo and Montagnier published a series of articles, one of which was co-written by both scientists, in which they acknowledged the pivotal roles that each had played in the discovery of HIV.
Awards and honors
The 2008 Nobel Prize in Physiology or Medicine was awarded to Montagnier and Françoise Barré-Sinoussi for the discovery of HIV. They shared the Prize with Harald zur Hausen, who discovered that human papilloma viruses can cause cervical cancer. Montagnier said he was "surprised" that Robert Gallo was not also recognized by the Nobel Committee: "It was important to prove that HIV was the cause of AIDS, and Gallo had a very important role in that. I'm very sorry for Robert Gallo." According to Maria Masucci, a member of the Nobel Assembly, "there was no doubt as to who made the fundamental discoveries."
Montagnier is the co-founder of the World Foundation for AIDS Research and Prevention and co-directs the Program for International Viral Collaboration. He is the founder and a former president of the Houston-based World Foundation for Medical Research and Prevention. He has received more than 20 major awards, including the National Order of Merit (Commander, 1986) and the Légion d'honneur (Knight: 1984; Officer: 1990; Commander: 1993; Grand Officer: 2009), He is a recipient of the Lasker Award and the Scheele Award (1986), the Louis-Jeantet Prize for medicine (1986), the Gairdner Award (1987), the Golden Plate Award of the American Academy of Achievement (1987), King Faisal International Prize (1993) (known as the Arab Nobel Prize), and the Prince of Asturias Award (2000). He is also a member of the Académie Nationale de Médecine.
Research on electromagnetic signals from DNA
In 2009, Montagnier published two independently made, controversial research studies, one of which was entitled "Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA Sequences." Jeff Reimers of the University of Sydney said that, if its conclusions are true, "these would be the most significant experiments performed in the past 90 years, demanding re-evaluation of the whole conceptual framework of modern chemistry". The paper concludes that diluted DNA from pathogenic bacterial and viral species is able to emit specific radio waves" and that "these radio waves [are] associated with 'nanostructures' in the solution that might be able to recreate the pathogen".
They were published in a new journal of which he is chairman of the editorial board, allegedly detecting electromagnetic signals from bacterial DNA (M. pirum and E. coli) in water that had been prepared using agitation and high dilutions, and similar research on electromagnetic detection of HIV RNA in the blood of AIDS patients treated by antiretroviral therapy.
On 28 June 2010, Montagnier spoke at the Lindau Nobel Laureate Meeting in Germany, "where 60 Nobel prize winners had gathered, along with 700 other scientists, to discuss the latest breakthroughs in medicine, chemistry and physics." He "stunned his colleagues ... when he presented a new method for detecting viral infections that bore close parallels to the basic tenets of homeopathy. Although fellow Nobel prize winners – who view homeopathy as quackery – were left openly shaking their heads, Montagnier's comments were rapidly embraced by homeopaths eager for greater credibility. Cristal Sumner, of the British Homeopathic Association, said Montagnier's work gave homeopathy 'a true scientific ethos'."
When asked by Canada's CBC Marketplace program if his work was indeed a theoretical basis for homeopathy as homeopaths had claimed, Montagnier replied that one "cannot extrapolate it to the products used in homeopathy".
Responses, criticisms and interview
The paper has met with harsh criticism for not being peer-reviewed, and its claims unsubstantiated by modern mainstream conventions of physics and chemistry. No third party has replicated the findings as of March 2015. In response to Montagnier's statement that the generally unfavorable response is due to the "non-understanding or misunderstanding of the breakthrough findings", blogger Andy Lewis has written that he has found it difficult to assert what the paper "actually claims" and that "The paper [...] lacks any rigour. [...]", as "important experimental steps are described dismissively in a sentence and little attempt is made to describe the detail of the work". While homeopaths claim his research as support for homeopathy, many scientists have greeted it with scorn and harsh criticism.
In a 24 December 2010 Science magazine interview entitled "French Nobelist Escapes ‘Intellectual Terror’ to Pursue Radical Ideas in China", he was questioned about his research and plans. In the interview he stated that Jacques Benveniste, whose controversial homeopathic work had been discredited, was "a modern Galileo". When asked if he wasn't "worried that your colleagues will think you have drifted into pseudo-science?", he replied "No, because it’s not pseudoscience. It’s not quackery. These are real phenomena which deserve further study." He also mentioned that his applications for funding had been turned down and that he was leaving his home country to set up shop in China so he could escape what he called the "intellectual terror" which he claimed had prevented others from publishing their results. He says that China's Shanghai Jiao Tong University is more "open minded" to his research. There he is chairman of the editorial board of a new journal which publishes his research.
Montagnier was also questioned on his beliefs about homeopathy, to which he replied: "I can’t say that homeopathy is right in everything. What I can say now is that the high dilutions are right. High dilutions of something are not nothing. They are water structures which mimic the original molecules. We find that with DNA, we cannot work at the extremely high dilutions used in homeopathy; we cannot go further than a 10−18 dilution, or we lose the signal. But even at 10−18, you can calculate that there is not a single molecule of DNA left. And yet we detect a signal."
A 12 January 2011 New Scientist editorial described the controversial nature of the research, while also noting how many researchers "reacted with disbelief", with Gary Schuster comparing it to "pathological science." biologist PZ Myers also described it as "pathological science." He described the paper as "one of the more unprofessional write-ups I've ever run across", and criticized the publication process as having an "unbelievable turnaround" time: "another suspicious sign are the dates. This paper was submitted on 3 January 2009, revised on 5 January 2009, and accepted on 6 January 2009", leading him to ask: "Who reviewed this, the author's mother? Maybe someone even closer. Guess who the chairman of the editorial board is: Luc Montagnier."
On 25 May 2012, he gave the keynote address at the 2012 conference for AutismOne, an anti-vaccination group. Similar to the controversy he aroused by extolling homeopathy, his latest group, Chronimed, claims to have made a discovery for autistic children that was sharply criticized by scientist Steven Salzberg.
In 2017, 106 academic scientists wrote an open letter "calling [Montagnier] to order". The letter read: "We, academics of medicine, cannot accept that one of our peers is using his Nobel prize [status] to spread dangerous health messages outside of his field of knowledge."
Legal battle over patent
In 2009, Montagnier became involved in a legal battle with inventor Bruno Robert over the intellectual property rights to the techniques used in the aforementioned research. Robert, who had tried to succeed the company Digibio created by Jacques Benveniste, approached Montagnier in May 2005 regarding his work on electromagnetic signals. In November 2005, Robert registered a patent for the process of homing in on a "biochemical element presenting a biological activity through the analysis of low-frequency electromagnetic signals." This patent was in fact written by Montagnier from results obtained between July and November 2005. A month later, INPI, France's patents body, received a request for the same patent from Montagnier, which was criticized by the patent examiner on multiple points, including the following:
- "... the invention is based on phenomena which contradict the fundamental principle of physics and of chemistry, i.e. the existence of biological or effect without an active molecule and no explanation or theoretical basis makes it impossible at the current time to explain the results obtained."
Montagnier took Robert to court, claiming that he had intellectual property rights over this process. However, Robert's lawyer alleged that Montagnier had already admitted that he had not come up with the discovery, as he had signed a contract to use Robert's technique in 2005. In response, Montagnier's lawyer said the pair had only signed a "protocol agreement" which was not legally binding. In July 2009, the court ruled that Robert's 2005 patent application was 'fraudulent', because it had subtracted all of Montagnier's contribution, which the court estimated at 50%.
In 2020, Montagnier argued that SARS-CoV-2, the virus that causes COVID-19, was man-made in a laboratory and that it might have been the result of an attempt to create a vaccine for HIV/AIDS. His allegation came after the United States had launched a probe into whether the virus came from a laboratory. According to Montagnier, the "presence of elements of HIV and germ of malaria in the genome of coronavirus is highly suspect and the characteristics of the virus could not have arisen naturally." Montagnier's conclusions were rejected as hasty by the scientific community, considering the gene sequences are common among similar organisms. As of September 2021[update], there is no evidence indicating the novel coronavirus is a man-made virus.
- And the Band Played On, a book written about the discovery of AIDS
- And the Band Played On, a film based on the book
- History of RNA biology
- HIV trial in Libya
- List of RNA biologists
- Louis-Jeantet Prize
- "Montagnier". The American Heritage Dictionary of the English Language (5th ed.). Boston: Houghton Mifflin Harcourt. Retrieved 10 August 2019.
- "Montagnier". Merriam-Webster Dictionary. Retrieved 10 August 2019.
- "news.bbc.co.uk, Nobel prize for viral discoveries". BBC News. 6 October 2008. Retrieved 15 May 2012.
- "SJTU Appointed Luc Montagnier University Chair Professor". En.sjtu.edu.cn. Archived from the original on 23 April 2020. Retrieved 15 May 2012.
- Grimes, David Robert. "COVID Has Created a Perfect Storm for Fringe Science". Scientific American. Retrieved 4 August 2021.
- Dupuy, Beatrice; Klepper, David; Amiri, Farnoush (26 April 2021). "The superspreaders behind top COVID-19 conspiracy theories". AP NEWS.
- Frutos, Roger; Gavotte, Laurent; Devaux, Christian A. (18 March 2021). "Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model". Infection, Genetics and Evolution: 104812. doi:10.1016/j.meegid.2021.104812. ISSN 1567-1348. PMC 7969828. PMID 33744401.
- Andersen, Kristian G.; Rambaut, Andrew; Lipkin, W. Ian; Holmes, Edward C.; Garry, Robert F. (April 2020). "The proximal origin of SARS-CoV-2". Nature Medicine. 26 (4): 450–452. doi:10.1038/s41591-020-0820-9. ISSN 1546-170X. PMC 7095063. PMID 32284615.
- France, Connexion. "French Nobel prize winner: 'Covid-19 was made in lab'". www.connexionfrance.com. Retrieved 24 July 2021.
- Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vézinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983). "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)". Science. 220 (4599): 868–871. Bibcode:1983Sci...220..868B. doi:10.1126/science.6189183. PMID 6189183. S2CID 390173.
- Popovic M, Sarngadharan MG, Read E, Gallo RC (1984). "Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS". Science. 224 (4648): 497–500. Bibcode:1984Sci...224..497P. doi:10.1126/science.6200935. PMID 6200935.
- Sheng-Yung P. Chang; Barbara H. Bowman; Judith B. Weiss; Rebeca E. Garcia; Thomas J. White (1993). "The origin of HIV-1 isolate HTLV-IIIB". Nature. 363 (6428): 466–469. Bibcode:1993Natur.363..466C. doi:10.1038/363466a0. PMID 8502298. S2CID 4288880. (Open access)
- "Summary of fraud accusation". Ori.hhs.gov. Retrieved 15 May 2012.
- Enserink, Martin. "Nobel Prize Surprise – ScienceNOW". Sciencenow.sciencemag.org. Retrieved 15 May 2012.
- DA Morgan; FW Ruscetti; R Gallo (10 September 1976). "Selective in vitro growth of T lymphocytes from normal human bone marrows". Science. Sciencemag.org. 193 (4257): 1007–1008. Bibcode:1976Sci...193.1007M. doi:10.1126/science.181845. PMID 181845. Retrieved 15 May 2012.
- "HIV, HPV Researchers Honored, But One Scientist is Left Out". Science. 322. October 2008. pp. 149–328.
- Hilts, Philip (13 November 1993). "U.S. Drops Misconduct Case Against an AIDS Researcher". The New York Times.
- Montagnier L (2002). "Historical essay. A History of HIV Discovery". Science. 298 (5599): 1727–8. doi:10.1126/science.1079027. PMID 12459575. S2CID 57481800.
- Gallo RC (2002). "Historical essay. The Early Years of HIV/AIDS". Science. 298 (5599): 1728–30. doi:10.1126/science.1078050. PMID 12459576. S2CID 82899411.
- Gallo RC, Montagnier L (2002). "Historical essay. Prospects for the Future". Science. 298 (5599): 1730–1. doi:10.1126/science.1079864. PMID 12459577. S2CID 34227893.
- Altman, Lawrence K. (7 October 2008). "Discoverers of AIDS and Cancer Viruses Win Nobel". The New York Times. Retrieved 11 May 2010.
- Altman, Lawrence (6 October 2008). "Three Europeans Win the 2008 Nobel for Medicine". The New York Times. Retrieved 6 October 2008.
- "Décret du 31 décembre 2008 portant élévation et nomination aux dignités de grand'croix et de grand officier". JORF. 2009 (1): 14. 1 January 2009. PREX0828225D. Retrieved 10 March 2009.
- "montagnier.org". montagnier.org. Retrieved 21 March 2018.
- "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
- "Académie Nationale de Médecine".
- "Honorary Degrees | Whittier College". www.whittier.edu. Retrieved 6 December 2019.
- Coghlan, Andy (12 January 2011). "Scorn over claim of teleported DNA". New Scientist. Retrieved 3 August 2021.
- "Editors". Interdisciplinary Sciences: Computational Life Sciences. Retrieved 3 August 2021.
- Montagnier, Luc; Aïssa, Jamal; Ferris, Stéphane; Montagnier, Jean-Luc; Lavalléee, Claude (4 March 2009). "Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences". Interdisciplinary Sciences: Computational Life Sciences. Springer Science and Business Media LLC. 1 (2): 81–90. doi:10.1007/s12539-009-0036-7. ISSN 1913-2751. PMID 20640822. S2CID 7158953.
- Montagnier, Luc; Aïssa, Jamal; Lavallée, Claude; Mbamy, Mireille; Varon, Joseph; Chenal, Henri (14 November 2009). "Electromagnetic detection of HIV DNA in the blood of AIDS patients treated by antiretroviral therapy". Interdisciplinary Sciences: Computational Life Sciences. Springer Science and Business Media LLC. 1 (4): 245–253. doi:10.1007/s12539-009-0059-0. ISSN 1913-2751. PMID 20640802. S2CID 29991828.
- "Meeting Program". lindau-nobel.org. 27 July 2011. Archived from the original on 27 July 2011. Retrieved 3 August 2021.
- "Nobel laureate gives homeopathy a boost - The Australian". theaustralian.com.au. 25 December 2010. Archived from the original on 25 December 2010. Retrieved 3 August 2021.
- "Cure Or Con?". CBC Marketplace. Archived from the original on 13 April 2014. Approx 17:00 of 22:29.
- Lewis, Andy. "Why I am Nominating Luc Montagnier for an IgNobel Prize – The Quackometer Blog". quackometer.net. Retrieved 3 August 2021.
- Myers, PZ (24 January 2011). "It almost makes me disbelieve that HIV causes AIDS!". ScienceBlogs. Retrieved 3 August 2021.
- "Why we have to teleport disbelief". New Scientist. 26 February 2019. Retrieved 3 August 2021.
- Enserink, M. (23 December 2010). "French Nobelist Escapes 'Intellectual Terror' to Pursue Radical Ideas in China". Science. American Association for the Advancement of Science (AAAS). 330 (6012): 1732. Bibcode:2010Sci...330.1732E. doi:10.1126/science.330.6012.1732. ISSN 0036-8075. Full article mirror
- "autismone.org". autismone.org. 5 September 2014. Archived from the original on 5 September 2014. Retrieved 3 August 2021.CS1 maint: unfit URL (link)
- Salzberg, Steven (27 May 2012). "Nobel laureate joins anti-vaccination crowd at Autism One". Forbes. Retrieved 3 August 2021.
- France, Connexion. "French Nobel prize winner: 'Covid-19 made in lab'". www.connexionfrance.com. Retrieved 25 May 2021.
- Basterfield, Candice; Lilienfeld, Scott; Bowes, Shauna; Costello, Thomas (2020). "The Nobel disease: When intelligence fails to protect against irrationality". Skeptical Inquirer. 44 (3): 32–37.
- Gorski, David (4 June 2012). "Luc Montagnier and the Nobel Disease". Science Based Medicine. sciencebasedmedicine.org. Retrieved 13 May 2020.
- "Montagnier's patent application". V3.espacenet.com. Retrieved 15 May 2012.
- Patent examiner's assessment, p. 10[permanent dead link]. World Intellectual Property Organization (WIPO), United Nations
- Samuel, Henry (8 March 2009). "Man who co-discovered HIV accused of stealing rights to Aids cure". The Daily Telegraph. London. Retrieved 4 August 2009.
- http://www.lematin.ch/flash-info/luc-montagnier-gagne-proces-paternite-brevets-contre-bruno-robert Archived 18 February 2012 at the Wayback Machine
- Perez, Jean Claude; Montagnier, Luc (1 August 2020). "COVID-19, SARS and Bats Coronaviruses Genomes Peculiar Homologous RNA Sequences". International Journal of Research — Granthaalayah. 8 (7): 217–263. doi:10.29121/granthaalayah.v8.i7.2020.678.
- Holmes, Edward C.; Goldstein, Stephen A.; Rasmussen, Angela L.; Robertson, David L.; Crits-Christoph, Alexander; Wertheim, Joel O.; Anthony, Simon J.; Barclay, Wendy S.; Boni, Maciej F.; Doherty, Peter C.; Farrar, Jeremy; Geoghegan, Jemma L.; Jiang, Xiaowei; Leibowitz, Julian L.; Neil, Stuart J.D.; Skern, Tim; Weiss, Susan R.; Worobey, Michael; Andersen, Kristian G.; Garry, Robert F.; Rambaut, Andrew (August 2021). "The Origins of SARS-CoV-2: A Critical Review". Cell. doi:10.1016/j.cell.2021.08.017. PMC 8373617. PMID 34480864.
|Wikimedia Commons has media related to Luc Montagnier.|
- The discovery of the AIDS virus in 1983 – Official position of the Pasteur Institute.
- Luc Montagnier on Nobelprize.org including the Nobel lecture 7 December 2008 25 Years after HIV Discovery: Prospects for Cure and Vaccine
- PROFILE: Luc Montagnier, Francoise Barre-Sinoussi – AIDS pioneers
- Luc Montagnier Foundation