CEP192

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CEP192
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CEP192, PPP1R62, centrosomal protein 192
External IDs MGI: 1918049 HomoloGene: 73526 GeneCards: CEP192
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018069
NM_032142

NM_027556

RefSeq (protein)

NP_115518

n/a

Location (UCSC) Chr 18: 12.99 – 13.13 Mb Chr 18: 67.8 – 67.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.[3][4] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.[5]

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.[5] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: centrosomal protein 192kDa". 
  4. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  5. ^ a b Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R.; Hyman, A.; Pelletier, L. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology. 18 (2): 136–141. doi:10.1016/j.cub.2007.12.055. PMID 18207742. 
  6. ^ Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology. 17 (22): 1960–1966. doi:10.1016/j.cub.2007.10.019. PMID 17980596. 

External links[edit]

Further reading[edit]