Diflorasone diacetate

Diflorasone diacetate
Clinical data
Trade names	Psorcon
AHFS/Drugs.com	Monograph
MedlinePlus	a602019
Routes of; administration	Topical
ATC code	D07AC10 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name [17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate;
CAS Number	2557-49-5 ;
PubChem CID	71414;
IUPHAR/BPS	7068;
DrugBank	DB00223 ;
ChemSpider	64504 ;
UNII	T2DHJ9645W;
KEGG	D01327 ;
ChEBI	CHEBI:31483 ;
ChEMBL	ChEMBL1201380 ;
CompTox Dashboard (EPA)	DTXSID8045646 ;
ECHA InfoCard	100.046.872
Chemical and physical data
Formula	C26H32F2O7
Molar mass	494.525 g/mol g·mol−1
	InChI InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 ; Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N ;
	(what is this?) (verify)

Diflorasone diacetate is a topical steroid that comes in the form of a cream. It is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis^[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I steroid (of classes I–IV).^[2]

No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.^{[citation needed]}

Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to an infant.^[3]

References

^ Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–132. doi:10.1159/000247323. PMID 8428041.
^ psoriasis.org: [www.psoriasis.org/sublearn03_mild_potency]
^ Drugs.com: Diflorasone topical

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[1] Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–132. doi:10.1159/000247323. PMID 8428041.

[psoriasis.org-2] soriasis.org: [www.psoriasis.org/sublearn03_mild_potency]

[Drugs.com-3] Drugs.com: Diflorasone topical

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