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EC number
CAS number 91195-87-8
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Endo-alpha-sialidase (EC, endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, endosialidase, endo-N) is an enzyme with systematic name polysialoside (2->8)-alpha-sialosylhydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction:

Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids


  1. ^ Finne, J.; Mäkelä, P.H. (1985). "Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid". J. Biol. Chem. 260 (2): 1265–1270. PMID 3968060. 
  2. ^ Hallenbeck, P.C.; Vimr, E.R.; Yu, F.; Bassler, B.; Troy, F.A. (1987). "Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units". J. Biol. Chem. 262 (8): 3553–3561. PMID 3546309. 
  3. ^ Kitakima, K.; Inoue, S.; Inoue, Y.; Troy, F.A. (1988). "Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies". J. Biol. Chem. 263 (34): 18269–18276. PMID 3142874. 
  4. ^ Kwiatkowski, B.; Boscheck, B.; Thicle, H.; Stirm, S. (1982). "Endo-N-acetylneuraminidase associated with bacteriophage particles". J. Virol. 43 (2): 697–704. PMC 256172Freely accessible. PMID 7109038. 
  5. ^ Pelkonen, S.; Pelkonen, J.; Finne, J. (1989). "Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins". J. Virol. 63 (10): 4409–4416. PMC 251059Freely accessible. PMID 2778882. 
  6. ^ Tombinson, S.; Taylor, P.W. (1985). "Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide". J. Virol. 55 (2): 374–378. PMC 254943Freely accessible. PMID 3894684. 
  7. ^ Cabezas, J.A. (1991). "Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase". Biochem. J. 278: 311–312. doi:10.1042/bj2780311. PMC 1151486Freely accessible. PMID 1883340. 

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