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[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Adenosine 5'-monophosphate, 5'-Adenylic acid
3D model (Jmol)
|Molar mass||347.22 g/mol|
|Appearance||white crystalline powder|
|Melting point||178 to 185 °C (352 to 365 °F; 451 to 458 K)|
|Boiling point||798.5 °C (1,469.3 °F; 1,071.7 K)|
|Acidity (pKa)||0.9, 3.8, 6.1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine, which does not have the typical high energy bond of the so called adenosine monophosphate ("AMP") that arises on the hydrolysis of ATP. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.
Production and degradation
- 2 ADP → ATP + AMP
- ADP → AMP + Pi
- ATP → AMP + PPi
When RNA is broken down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed.
AMP can be regenerated to ATP as follows:
- AMP + ATP → 2 ADP (adenylate kinase in the opposite direction)
- ADP + Pi → ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation)
In a catabolic pathway, adenosine monophosphate can be converted to uric acid, which is excreted from the body.
AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. cAMP plays an important role in intracellular signaling.