Galactosamine-6 sulfatase

GALNS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4FDJ, 4FDI
Identifiers
Aliases	GALNS, galactosamine (N-acetyl)-6-sulfatase, GALNAC6S, GAS, GalN6S, MPS4A
External IDs	OMIM: 612222 MGI: 1355303 HomoloGene: 55468 GeneCards: GALNS
Gene location (Human)
Chr.	Chromosome 16 (human)
End	88,856,970 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,338,202 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sperm; ; stromal cell of endometrium; ; pituitary gland; ; anterior pituitary; ; bronchial epithelial cell; ; right adrenal gland; ; blood; ; canal of the cervix; ; left uterine tube;
	Top expressed in
	proximal tubule; ; kidney; ; ileum; ; molar; ; internal carotid artery; ; yolk sac; ; intestinal villus; ; submandibular gland; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	N-acetylgalactosamine-4-sulfatase activity; N-acetylgalactosamine-6-sulfatase activity; sulfuric ester hydrolase activity; catalytic activity; hydrolase activity; metal ion binding; arylsulfatase activity;
Cellular component	lysosome; lysosomal lumen; extracellular exosome; extracellular region; azurophil granule lumen;
Biological process	metabolism; keratan sulfate catabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	2588
	50917
	ENSG00000141012
	ENSMUSG00000015027
	P34059
	Q571E4
	NM_000512; NM_001323543; NM_001323544
	NM_001193645; NM_016722
	NP_000503; NP_001310472; NP_001310473
	NP_001180574; NP_057931
	Wikidata
View/Edit Human	View/Edit Mouse

N-acetylgalactosamine-6-sulfatase is an enzyme that, in humans, is encoded by the GALNS gene.^[5]^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141012 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tomatsu S, Fukuda S, Masue M, Sukegawa K, Fukao T, Yamagishi A, Hori T, Iwata H, Ogawa T, Nakashima Y, et al. (Jan 1992). "Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase". Biochem Biophys Res Commun. 181 (2): 677–83. doi:10.1016/0006-291X(91)91244-7. PMID 1755850.
^ "Entrez Gene: GALNS galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)".

External links

GALNS+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141012 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1755850-5] Tomatsu S, Fukuda S, Masue M, Sukegawa K, Fukao T, Yamagishi A, Hori T, Iwata H, Ogawa T, Nakashima Y, et al. (Jan 1992). "Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase". Biochem Biophys Res Commun. 181 (2): 677–83. doi:10.1016/0006-291X(91)91244-7. PMID 1755850.

[entrez-6] "Entrez Gene: GALNS galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)".

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References

Further reading

External links