PAPSS1

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PAPSS1
Protein PAPSS1 PDB 1x6v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PAPSS1, ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
External IDs MGI: 1330587 HomoloGene: 81740 GeneCards: PAPSS1
RNA expression pattern
PBB GE PAPSS1 209043 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005443

NM_001289477
NM_001289478
NM_001289479
NM_011863

RefSeq (protein)

NP_005434

NP_035993.1
NP_001276406
NP_001276407
NP_001276408
NP_035993

Location (UCSC) Chr 4: 107.59 – 107.72 Mb Chr 3: 131.56 – 131.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.[3][4][5]

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Girard JP, Baekkevold ES, Amalric F (May 1998). "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase". FASEB J. 12 (7): 603–12. PMID 9576487. 
  4. ^ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62. doi:10.1038/2458. PMID 9771708. 
  5. ^ a b "Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1". 

Further reading[edit]