Glycoside hydrolase family 108
| Glycosyl hydrolase 108 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_108 | ||||||||
| Pfam | PF05838 | ||||||||
| Pfam clan | CL0037 | ||||||||
| CAZy | GH108 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 108 CAZY GH_108 includes enzymes with lysozyme (N-acetylmuramidase) EC 3.2.1.17 activity. A glutamic acid residue within a conserved Glu-Gly-Gly-Tyr motif is essential for catalytic activity.[8] In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion.[9][10]
References
- ^ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
- ^ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 ( Pt 2) (Pt 2): 695–6. PMC 1217404. PMID 8687420.
- ^ "Home". CAZy.org. Retrieved 2018-03-06.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490-5. doi:10.1093/nar/gkt1178. PMID 24270786.
- ^ "Glycoside Hydrolase Family 108". CAZypedia.org. Retrieved 2018-03-06.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563.
- ^ Stojković EA, Rothman-Denes LB (2007). "Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases". J Mol Biol. 366 (2): 406–19. doi:10.1016/j.jmb.2006.11.028. PMID 17174325.
- ^ Pei J, Grishin NV (2005). "COG3926 and COG5526: a tale of two new lysozyme-like protein families". Protein Sci. 14 (10): 2574–81. doi:10.1110/ps.051656805. PMC 2253296. PMID 16155206.
- ^ Kondo Y, Toyoda A, Fukushi H, Yanase H, Tonomura K, Kawasaki H, et al. (1994). "Cloning and characterization of a pair of genes that stimulate the production and secretion of Zymomonas mobilis extracellular levansucrase and invertase". Biosci Biotechnol Biochem. 58 (3): 526–30. doi:10.1271/bbb.58.526. PMID 7764692.