Glycoside hydrolase family 26

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Glycosyl hydrolase family 26
Symbol Glyco_hydro_26
Pfam PF02156
Pfam clan CL0058
SCOP 1gvy
OPM superfamily 125
OPM protein 2vi0

In molecular biology, glycoside hydrolase family 26 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]

Glycoside hydrolase family 26 CAZY GH_26 comprises enzymes with two known activities; mannanase (EC and β-1,3-xylanase (EC

Family 26 encompasses mainly mannan endo-1,4-beta-mannosidases. Mannan endo-1,4-beta-mannosidase hydrolyses mannan and galactomannan, but displays little activity towards other plant cell wall polysaccharides.[8] The enzyme randomly hydrolyses 1,4-beta-D-linkages in mannans, galacto-mannans, glucomannans and galactoglucomannans.


  1. ^ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477Freely accessible. PMID 7624375. 
  2. ^ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. 
  3. ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 ( Pt 2) (Pt 2): 695–6. PMC 1217404Freely accessible. PMID 8687420. 
  4. ^ "Home". Retrieved 2018-03-06. 
  5. ^ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMID 24270786. 
  6. ^ "Glycoside Hydrolase Family 26". Retrieved 2018-03-06. 
  7. ^ "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563. 
  8. ^ Braithwaite KL, Black GW, Hazlewood GP, Ali BR, Gilbert HJ (February 1995). "A non-modular endo-beta-1,4-mannanase from Pseudomonas fluorescens subspecies cellulosa". The Biochemical Journal. 305 ( Pt 3): 1005–10. PMC 1136358Freely accessible. PMID 7848261.