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Inosine nucleosidase

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inosine nucleosidase
Identifiers
EC no.3.2.2.2
CAS no.9030-95-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an inosine nucleosidase (EC 3.2.2.2) is an enzyme that catalyzes the chemical reaction

inosine + H2O D-ribose + hypoxanthine

Thus, the two substrates of this enzyme are inosine and H2O, whereas its two products are D-ribose and hypoxanthine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is inosine ribohydrolase. Other names in common use include inosinase, and inosine-guanosine nucleosidase. This enzyme participates in purine metabolism.

References

  • KOCH AL (1956). "Some enzymes of nucleoside metabolism of Escherichia coli". J. Biol. Chem. 223 (1): 535–49. PMID 13376622.
  • Tarr HLA (1955). "Fish muscle riboside hydrolases". Biochem. J. 59 (3): 386–391. PMC 1216255. PMID 14363106.